QUANTITATIVE AND QUALITITATIVE FLUORESCENCE MODULATED IMAGING AND TOMOGRAPHY

定量和定性荧光调制成像和断层扫描

• 批准号: 8362634
• 负责人: ANTHONY J DURKIN
• 金额: $ 3.89万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362634
• 关键词: Algorithms; Biotechnology; Fluorescence; Funding; Grant; Image; Lasers; Measurement; Measures; Metric; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; fluorophore; quantum; reconstruction; tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this study is to demonstrate Fluorescent modulated imaging (fMI) via the quantitative and qualitative measurement of fluorophore phantoms. Fluorescent perturbations with various spatial and depth profiles in phantoms will be investigated. Qualititatively, the ability for spatial localization of the fluorophore. Quantitatively, the ability to measure fluorophore concentration as well as concentration and pH independent fluorophore metrics such as quantum yield will be investigated. Finally, tomographic reconstruction algorithms will be developed in parallel.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 本研究的目的是通过荧光团模型的定量和定性测量来演示荧光调制成像 (fMI)。将研究体模中各种空间和深度剖面的荧光扰动。 定性地，荧光团空间定位的能力。 定量地，将研究测量荧光团浓度以及与浓度和 pH 无关的荧光团指标（例如量子产率）的能力。 最后，将并行开发断层重建算法。