IMPLEMENTATION OF HIFI ON BRUKER SPECTROMETER

HIFI 在 BRUKER 光谱仪上的实现

• 批准号: 8361184
• 负责人: JOHN LUTE MARKLEY
• 金额: $ 0.72万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361184
• 关键词: Collaborations; Data Analyses; Data Collection; Frequencies; Funding; Grant; Methods; National Center for Research Resources; Principal Investigator; Proteins; Research; Research Infrastructure; Resolution; Resources; Source; United States National Institutes of Health; base; cost; data acquisition; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. NMRFAM in collaboration with CESG has developed novel automated approaches to protein NMR data collection and analysis. An adaptive and interactive engine for identifying peaks in 3D triple-resonance spectra in a probabilistic manner is based on ideas of reduced-dimensionality and tilted-plane data collection. The method, called "High-Resolution Iterative Frequency Identification" (HIFI)-NMR. Current project is to implement HIFI on Bruker spectrometer for automatic NMR data acquisition and analysis.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 NMRFAM 与 CESG 合作开发了蛋白质 NMR 数据收集和分析的新型自动化方法。用于以概率方式识别 3D 三重共振谱中的峰值的自适应和交互式引擎基于降维和倾斜平面数据收集的思想。该方法称为“高分辨率迭代频率识别”(HIFI)-NMR。目前的项目是在布鲁克光谱仪上实现 HIFI，用于自动 NMR 数据采集和分析。