BISPHENOL A METABOLISM AND EFFECTS IN A PRIMATE MODEL

双酚 A 在灵长类动物模型中的代谢和影响

• 批准号: 8357337
• 负责人: CATHERINE A VANDEVOORT
• 金额: $ 7.56万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357337
• 关键词: Adult; Affect; California; Chemicals; Collection; Data; Drug or chemical Tissue Distribution; Excretory function; Exposure to; Female; Fetus; Foundations; Funding; Grant; Health Policy; Human; Macaca mulatta; Metabolism; Modeling; Mus; National Center for Research Resources; Oogenesis; Pathway interactions; Primates; Principal Investigator; Production; Research; Research Infrastructure; Research Personnel; Resources; Source; Tissues; United States National Institutes of Health; base; biological systems; bisphenol A; cost; exposed human population; fetal; pregnant; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bisphenol A (BPA) is one of the highest volume chemicals in production, and over 90% of people in the US are exposed to low levels on a daily basis. Recent studies in the mouse indicate that exposure to low levels of this estrogenic chemical adversely affects a wide range of biological systems. However, there is a lack of information about the relevance of mouse studies to human exposure, which has prevented the use of these studies to inform human health policy decisions. Data from a primate model will help to bridge the gap between mouse and human. This proposal supports supplemental activities to an already funded grant from NIH. The funded grant "Effects of Fetal Bisphenol A Exposure on Oogenesis in Primates" involves the treatment of adult, pregnant female rhesus monkeys with BPA and the assessment of effects on oogenesis in female fetuses. This project covers two additional activities: 1) a study of the fate of BPA once it is orally ingested to determine the tissue distribution and excretion pathways and, 2) funds to support the collection and distribution of primate tissues from an ongoing NIH funded study to other Passport Foundation-funded investigators.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 双酚 A (BPA) 是生产量最大的化学品之一，超过 90% 的美国人每天都会接触少量的双酚 A。最近对小鼠的研究表明，接触低水平的这种雌激素化学物质会对广泛的生物系统产生不利影响。 然而，缺乏关于小鼠研究与人类暴露的相关性的信息，这阻碍了利用这些研究来为人类健康政策决策提供信息。 来自灵长类动物模型的数据将有助于弥合小鼠和人类之间的差距。 该提案支持对 NIH 已资助的赠款进行补充活动。 资助的赠款“胎儿双酚 A 暴露对灵长类动物卵子发生的影响”涉及用 BPA 治疗成年、怀孕雌性恒河猴以及评估对雌性胎儿卵子发生的影响。 该项目涵盖另外两项活动：1) 研究口服 BPA 后的命运，以确定其组织分布和排泄途径；2) 资助一项正在进行的 NIH 资助的研究，以支持灵长类动物组织的收集和分配其他护照基金会资助的调查人员。