Training of Ugandans in Basic Research on TB and Emerging Infectious Diseases

对乌干达人进行结核病和新发传染病基础研究培训

• 批准号: 8664524
• 负责人: Jerrold J. Ellner
• 金额: $ 13.86万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-12 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8664524
• 关键词: Address; Advanced Development; American; Basic Science; Biological Markers; Boston; British; Centers for Disease Control and Prevention (U.S.); Clinical Trials; Developing Countries; Development; Diagnostic; Emerging Communicable Diseases; Epidemiology; European; Evaluation; Faculty; Foundations; Funding; Future; Goals; HIV; Immunity; Immunology; Institution; Laboratories; Medical Research; Microbiology; Needs Assessment; Pathogenesis; Pharmaceutical Preparations; Postdoctoral Fellow; Qualifying; Research; Research Infrastructure; Research Training; Scientist; Site; Specimen; Time; Training; Training Programs; Training Support; Translational Research; Treatment Protocols; Tropical Disease; Trust; Tuberculosis; Uganda; United States National Institutes of Health; Universities; Vaccine Therapy; Vaccines; graduate student; improved; medical schools; novel diagnostics; programs; translational study

DESCRIPTION (provided by applicant): In the last decade, Makerere University (MU) in Kampala, Uganda, has become one of the principal academic institutions worldwide for collaborative research on TB. Currently NIH, CDC, Gates Foundation, Wellcome Trust, British Medical Research Council and the European & Developing Countries Clinical Trials Partnership provide substantial support to TB research in Uganda, including evaluation of new diagnostics; drug treatment regimens; vaccines and translational studies of pathogenesis and correlates of immunity. NIH has supported training in epidemiology; immunology and microbiology related to HIV, while Wellcome Trust funds a capacity-building program in the immunology of tropical diseases. Despite these efforts, training in basic and translational research on TB lags far behind the pressing need. For example, the development of improved TB diagnostics, vaccines and therapies requires the discovery of biomarkers. Uganda is a leading site for research on biomarkers but relies on expatriate scientists for developmental research and often on shipment of specimens for off-site analysis. With development of advanced laboratory infrastructure at MU and other sites in Uganda, the lack of well-trained independent Ugandan scientists conducting basic and translational research at MU is neither necessary nor appropriate. This training program is the product of a needs assessment by academic leaders of MU and Boston University (BU). It is time to provide basic research training to qualified Ugandan scientists equivalent to that available to American graduate students and post-doctoral fellows. As there is growing infrastructure to support independent Ugandan-led research, we have organized this program so that following training, trainees will return to MU as academic faculty and will have the opportunity to establish valuable research programs on tuberculosis and other emerging infectious diseases in Uganda. The Aims of this Program are tailored to address the current and future needs of MU. The capacity-building program helps fill the gaps identified in the needs assessment and addresses priority developmental goals of MU School of Medicine.

描述（由申请人提供）：在过去十年中，位于乌干达坎帕拉的麦克雷雷大学 (MU) 已成为全球结核病合作研究的主要学术机构之一。目前，美国国立卫生研究院、疾病预防控制中心、盖茨基金会、威康信托基金、英国医学研究委员会和欧洲与发展中国家临床试验伙伴关系为乌干达的结核病研究提供大力支持，包括对新诊断方法的评估；药物治疗方案；疫苗以及发病机制和免疫相关性的转化研究。 NIH 支持流行病学培训；与艾滋病毒相关的免疫学和微生物学，而威康信托基金会资助热带疾病免疫学的能力建设项目。尽管做出了这些努力，结核病基础研究和转化研究的培训仍远远落后于迫切的需求。例如，改进结核病诊断、疫苗和疗法的开发需要发现生物标志物。乌干达是生物标志物研究的领先国家，但依赖外籍科学家进行发展研究，并经常依靠运送标本进行异地分析。随着密苏里大学和乌干达其他地点先进实验室基础设施的发展，缺乏训练有素的独立乌干达科学家在密苏里大学进行基础和转化研究既没有必要也不合适。该培训计划是密西根大学和波士顿大学 (BU) 学术领导者需求评估的产物。现在是时候为合格的乌干达科学家提供相当于美国研究生和博士后研究员的基础研究培训了。由于支持乌干达主导的独立研究的基础设施不断增长，我们组织了这个项目，以便培训结束后，学员将作为学术教师返回密西根大学，并将有机会在乌干达建立关于结核病和其他新发传染病的有价值的研究项目。该计划的目标是为了满足密苏里大学当前和未来的需求而定制的。能力建设计划有助于填补需求评估中发现的空白，并实现密西根大学医学院的优先发展目标。