Quantifying Determinants of Spray Painters' Isocyanurate Exposure

量化喷漆工异氰脲酸酯暴露的决定因素

• 批准号: 8695659
• 负责人: LEENA A NYLANDER-FRENCH
• 金额: $ 30.91万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8695659
• 关键词: Quantifying; Determinants; Spray; Painters; Isocyanurate

DESCRIPTION (provided by applicant): Exposure assessment studies published to date have not included biomarker analysis of isocyanurate (an oligomer of 1,6-hexamethylene diisocyanate) exposure, which constitutes the greatest inhalation and skin exposure in spray painters. Further, the sensitization capacity of isocyanurate is greater than 1,6- hexamethylene diisocyanate monomer (HDI) or HDI biuret. We propose to investigate and determine how individual and environmental factors affect isocyanurate and HDI monomer exposure-biomarker associations in our well-characterized worker population of spray painters. To achieve our goal, we will utilize quantitative measures of inhalation and dermal exposure and biomarker levels over multiple independent sampling visits as well as sophisticated exposure modeling that will allow us to link the observed biomarker levels to other predictors of systemic exposure such as personal and workplace factors. Through this approach, we will obtain quantitative data that will distinguish between isocyanurate and HDI monomer exposure and, thus, provide a major advance in characterizing both isocyanurate and HDI monomer exposures through multiple exposure routes. Demonstration and quantification of sources of individual differences in systemic exposure will significantly contribute to establishing realistic exposure-dose relationships. This proposed research project, to our knowledge, represents the first comprehensive study to measure both HDI monomer and its oligomer isocyanurate exposures and their specific metabolites as biomarkers in exposed workers. The data obtained will fill major data gaps within the exposure-biomarker relationship continuum regarding HDI oligomer and monomer exposures and, thus, will significantly contribute towards realistic exposure assessment for spray painters who have an increased risk of developing isocyanate-related adverse health effects. This research project will benefit two NIOSH NORA sectors: Services (Automotive Body, Paint, and Interior Repair and Maintenance) and Manufacturing (Paint, Coating, and Adhesive Manufacturing) by providing critical new information on isocyanurate and HDI monomer exposures as well as on factors affecting individual differences in exposure and biomarker levels. This research may also allow us to provide useful input in setting exposure limits by taking into account the individual variation in exposure and biomarker levels to both isocyanurate and HDI monomer.

描述（由申请人提供）：迄今为止发布的暴露评估研究还不包括异氰尿素酸盐（1,6-己酰胺二异氰酸酯的低聚物）暴露的生物标志物分析，这构成了喷雾画中最大的吸入和Skin暴露。此外，异氰尿素的敏化能力大于1,6-六甲基二异氰酸酯单体（HDI）或HDI BIURET。我们建议调查并确定个人和环境因素如何影响我们表征良好的喷雾画家工人人群中的异氰酸酯和HDI单体暴露 - 生物标志物关联。为了实现我们的目标，我们将在多个独立的采样访问中利用吸入和皮肤暴露和生物标志物水平的定量度量，以及复杂的暴露模型，这将使​​我们能够将观察到的生物标志物水平与其他系统性暴露（例如个人和工作场所因素）联系起来。通过这种方法，我们将获得定量数据，这些数据将区分异氰酸酯和HDI单体暴露，因此，通过多种暴露途径来表征异氰酸酯和HDI单体暴露方面的重大进展。在系统性暴露中的个体差异来源的演示和量化将显着有助于建立现实的暴露剂量关系。据我们所知，该提出的研究项目代表了第一个综合研究，用于测量HDI单体及其低聚物异构酸盐暴露及其特定代谢物作为暴露工人的生物标志物。获得的数据将填补有关HDI低聚物和单体暴露的暴露双重标志物关系中的主要数据差距，因此，对于具有增加异氰酸酯相关的不良健康影响风险增加的喷雾画家的现实风险评估将极大地促进现实的暴露评估。该研究项目将使两个NIOSH NORA领域受益：服务（汽车车身，油漆和内部维修和维护）以及制造（油漆，涂料和粘合剂制造），通过提供有关异氰尿布酸盐和HDI单体暴露以及影响暴露和生物标志物中个人差异的因素的关键新信息。这项研究还可能使我们能够通过考虑到异氰酸酯和HDI单体的个人暴露和生物标志物水平的各个差异来提供有用的输入。