National Consortium on Alcohol and NeuroDevelopment in Adolescence:Pittsburgh

国家青少年酒精与神经发育联盟：匹兹堡

基本信息

批准号：
8693887
负责人：
DUNCAN B. CLARK
金额：
$ 50.99万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-05 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8693887
关键词：
Abstinence Address Adolescence Adolescent Adult Advanced Development Adverse effects Affect Affective Age Alcohol consumption Alcohol or Other Drugs use Alcoholic Intoxication Alcoholism Alcohols Anatomy Area Behavioral Behavioral inhibition Brain Brain imaging California Cerebrum Characteristics Childhood Clinical assessments Cognitive Communities DNA Data Development Diagnostic Diffusion Magnetic Resonance Imaging Dose Drug usage Family history of Foundations Functional Magnetic Resonance Imaging Future Goals Heavy Drinking Human Imaging Techniques International Laboratories Longitudinal Studies Magnetic Resonance Imaging Measures Mental Health Neurobiology Neurocognitive Neuropsychological Tests Outcome Pattern Population Prevention Protocols documentation Psychopathology Recruitment Activity Regulation Reporting Research Resolution Rest Rewards Risk Risk Factors Role Saccades Sampling Site Sleep Sleep Architecture Sleep Stages Structure Substance Use Disorder System Teenagers Universities Visit adolescent alcohol alcohol abstinence alcohol and other drug alcohol consequences alcohol effect alcohol exposure alcohol use disorder base disorder risk drinking follow-up genetic analysis high risk longitudinal design medical specialties neurodevelopment neuroimaging neuropsychological psychobiologic psychologic relating to nervous system response sex twelfth grade underage drinking white matter young adult

项目摘要

DESCRIPTION (provided by applicant): In response to RFA-AA-12-006, this application proposes the Pittsburgh Research Component of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA: Pittsburgh) to determine the effects of alcohol use on the developing adolescent brain. Recruited at ages 12 through 21, a high risk enhanced community sample of 170 Pittsburgh subjects (N=680 from all sites) will complete a baseline assessment and undergo three annual follow-up assessments in an accelerated longitudinal design. At each visit, a multimodal magnetic resonance imaging (MRI) protocol, comprehensive neuropsychological battery, and assessments of alcohol and other substance use and related problems, mental health symptomatology, and substance use disorder risk factors will be measured. Brain imaging includes state-of-the-art high resolution structural MRI (sMRI), diffusion tensor imaging (DTI), and resting state MRI (rsMRI). The examination of alcohol consequences will focus on structural and functional maturation of brain areas that are actively developing during adolescence, involved in psychological regulation, responsive to rewards, and thought to be vulnerable to toxic alcohol effects. In addition, NCANDA: Pittsburgh will collaborate on two supplemental studies. We will collaborate with NCANDA: Duke in a study utilizing functional MRI to examine cerebral activation during a reward modulated anti-saccade task to study alcohol effects on reward responding and behavioral inhibition. We will also collaborate with NCANDA: SRI in a laboratory sleep study to examine the effects of alcohol on adolescent sleep architecture. Studied in the context of risks and baseline brain characteristics, we will determine both the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent at elevated risk for an alcohol use disorder.

描述（由申请人提供）：为了响应RFA-AA-12-006，本申请提出了匹兹堡青少年酒精和神经发育联盟的匹兹堡研究组成部分（NCANDE：匹兹堡），以确定酒精使用对发展青春期大脑的影响。在12至21岁时招募，高风险增强了170名匹兹堡受试者的社区样本（来自所有地点的n = 680）将完成基线评估，并在加速的纵向设计中进行三项年度随访评估。每次访问时，将测量多模式磁共振成像（MRI）方案，全面的神经心理电池以及对酒精和其他药物使用以及相关问题的评估，心理健康症状和使用物质使用障碍风险因素。大脑成像包括最先进的高分辨率结构MRI（SMRI），扩散张量成像（DTI）和静止状态MRI（RSMRI）。对酒精后果的检查将集中于在青春期积极发展的大脑区域的结构和功能成熟，参与心理调节，对奖励的反应，并被认为容易受到有毒酒精影响的影响。此外，NCANDA：匹兹堡将合作进行两项补充研究。我们将与Ncanda：Duke合作，利用功能性MRI进行研究，以检查奖励调制的反扫视任务中的脑激活，以研究酒精对奖励响应和行为抑制的影响。我们还将与Ncanda：SRI合作进行实验室睡眠研究，以研究酒精对青少年睡眠建筑的影响。在风险和基线大脑特征的背景下进行了研究，我们将确定酒精暴露对青春期人脑发育轨迹的影响，并确定先前存在的心理生物学脆弱性，这些脆弱性可能使青少年处于酒精使用障碍的风险较高。