A Longitudinal Resource for Genetic Research in Behavioral & Health Sciences

行为遗传学研究的纵向资源

• 批准号: 8662122
• 负责人: Jeremy J Freese
• 金额: $ 171.05万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8662122
• 关键词: Address; Adolescence; Affect; Aging; Attention; Behavior; Behavioral Sciences; Bioinformatics; Biosocial; Brothers; Cause of Death; Characteristics; Cognition; Cohort Studies; Complement; Confidentiality; DNA; Data; Data Protection; Databases; Death Records; Development; Disease; Economics; Ensure; Environmental Risk Factor; European; Family; Framingham Heart Study; Genetic; Genetic Markers; Genetic Research; Genomics; Genotype; Goals; Hand; Health; Health Sciences; Health behavior; Home environment; Human; Income; Individual; Interview; Joints; Length; Life Cycle Stages; Link; Longitudinal Studies; Mails; Measures; Medical; Medicare; Mental Health; Participant; Personality; Phenotype; Policies; Population; Privacy; Procedures; Process; Qualifying; Quality Control; Recommendation; Recording of previous events; Records; Research; Research Personnel; Resources; Retirement; Salivary; Sample Size; Sampling; Science; Secure; Siblings; Sister; Social Environment; Social Sciences; Social Security; Stratification; Surveys; Taxes; Time; United States National Institutes of Health; Wisconsin; aged; behavioral/social science; career; data sharing; database of Genotypes and Phenotypes; design; disability; family genetics; follow-up; frontier; genetic analysis; genetic resource; genome wide association study; high school; improved; interest; mortality; physical conditioning; psychologic; public health relevance; social; socioeconomics

DESCRIPTION (provided by applicant): This project will conduct genetic analysis on 10,000 participants in the Wisconsin Longitudinal Study (WLS), a highly productive 53-year long study of the life course of Wisconsin high school graduates of 1957 and their randomly selected siblings. WLS data cover cognition; social and economic background; educational, career, and family histories; earnings, income, and wealth; psychological and health measures; and multiple causes of death. We expect 10,000 samples: 5223 graduates and 2924 sibling samples currently in hand and~1900 currently being collected. There will be more than 2500 sibling pairs. Phenotypic data from the WLS have long been public, with appropriate protections of the privacy and confidentiality of participants. Similarly, we plan to share rich genomic data, which will be obtained using the Illumina HumanOmniExpress beadchip. Researchers, via varying mechanisms, will have access to all of the genetic and phenotypic data WLS has to offer. Further, our procedures and mechanisms to access these data are designed to reduce barriers to access and use, while still ensuring protections for our research participants. Adding genetic data to the WLS will help to create a consortium of large longitudinal studies of aging with harmonized phenotypic and extensive genomic data, e.g., combining the Wisconsin Longitudinal Study, the Health and Retirement Study, and other studies. The project will create a platform for discovery at the frontier of biosocial research.

描述（由申请人提供）：该项目将对威斯康星州纵向研究（WLS）的10,000名参与者进行遗传分析，这是一项对1957年威斯康星州高中毕业生及其随机选择的兄弟姐妹的生命研究课程的高产53年。 WLS数据涵盖认知；社会和经济背景；教育，职业和家庭历史；收入，收入和财富；心理和健康措施；和多种死亡原因。我们预计有10,000个样本：目前有5223名毕业生和2924个兄弟姐妹样本，目前正在收集约1900个。将有超过2500个兄弟姐妹对。 WLS的表型数据长期以来一直是公开的，并适当保护参与者的隐私和机密性。同样，我们计划共享丰富的基因组数据，这些数据将使用Illumina Handomniexpress beadchip获得。通过不同的机制，研究人员将可以访问所有WLS所提供的所有遗传和表型数据。此外，我们的访问这些数据的程序和机制旨在减少访问和使用的障碍，同时仍确保对我们的研究参与者进行保护。将遗传数据添加到WLS中将有助于创建一个与统一的表型和广泛的基因组数据的大型纵向研究的财团，例如，将威斯康星州纵向研究，健康和退休研究以及其他研究结合在一起。该项目将在生物社会研究边界创建一个发现平台。