Barriers in Translating Genomic Research into State Public Health Programs

将基因组研究转化为国家公共卫生计划的障碍

基本信息

批准号：
8690934
负责人：
Laura Senier
金额：
$ 17.65万
依托单位：
NORTHEASTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-23 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8690934
关键词：
Address Administrator Adult Attention Attitude Bioethics Biotechnology Career Choice Caring Case Study Chicago Child Care Chronic Disease Clinical Services Collaborations Commit Communities Congenital Abnormality Connecticut Consensus Data Development Diffusion Diffusion of Innovation Dimensions Doctor of Philosophy Economics Education and Outreach Effectiveness Elements Empirical Research Ensure Ethical Issues Ethics Evaluation Evaluation Research Face Genes Genetic Genetic Markers Genetic Programming Genetic Services Genomics Goals Guidelines Health Health Personnel Health Policy Health Sciences Healthcare Hereditary Disease Human Genome Project Individual Institutes Interview Investments Knowledge Laws Lead Leadership Legal Life Cycle Stages Maternal and Child Health Medicine Mentored Research Scientist Development Award Mentors Mentorship Michigan Mission Modeling Modernization National Human Genome Research Institute Neonatal Screening New York Onset of illness Outcome Patients Policies Policy Analysis Politics Population Population Genetics Population Surveillance Program Development Program Evaluation Public Health Public Policy Qualifying Qualitative Methods Recruitment Activity Registries Research Research Activity Research Design Research Infrastructure Research Methodology Research Personnel Research Training Resources Sampling Science Science Policy Services Sociology Solutions Stigmatization Strategic Planning Structure Study Section Suggestion System Theoretical model Time Training Training Activity Translating Translational Research Universities Utah Variant Wisconsin Work base burden of illness career comparative cost cost effective design evidence base expectation genetic technology improved innovation medical specialties medically underserved meetings multidisciplinary organizational structure population health professor programs public education public health relevance response social sound

项目摘要

DESCRIPTION (provided by applicant): This revised application for a Mentored Research Scientist Development Award (K01) is designed to support the career of Laura Senier, MPH, PhD, an assistant professor at the University of Wisconsin-Madison. Dr. Senier's goals are (1) to obtain additional training in population genetics, public policy analysis, and ethical frameworks governing emerging genetic technologies; (2) to build a research program that explores technical, political, and ethical barriers in translating genetic discoveries to public health poliies and programs; and (3) to become an independent investigator in the politics of research translation. Dr. Senier will accomplish these goals through a combination of formal coursework, mentored collaboration, and empirical research on state public health policy. The research plan examines the modernization of public health genetics programs in state health agencies. The specific aims are to (Aim 1a) describe the conceptual models, organizational structures, and financing solutions that state health agencies are using to modernize public health genetics programs; (Aim 1b) explore the opinions and attitudes of stakeholders about the scope and suitability of state public health genetics programs; (Aim 2a) through a comparative case study, identify the critical elements that impede or promote integration of genetics into public health; and (Aim 2b) explain how public health genetics programs vary under different structural arrangements, and show how the opinions of stakeholders influence public health genetics programming. In response to questions from study section reviewers, this revised application clarifies the sampling strategy and explains the analytic method of the qualitative comparative case study more thoroughly. The research will be based on original data collected via field observation, in-depth interviews, and archival analysis of state public health genetics activities n four states (Michigan, Connecticut, New York, and Utah). Dr. Senier has recruited an interdisciplinary mentor committee to guide her in these training and research activities. Dr. Pila Ossorio (Associate Professor of Law and Bioethics), Dr. Daniel Kleinman (Professor and Chair of Community & Environmental Sociology), Dr. Tom Oliver (Professor of Population Health Sciences), and Dr. D. Paul Moberg, (Director, Population Health Institute) will guide Dr. Senier in these endeavors. At the suggestion of study section reviewers, Dr. Nancy Cox (University of Chicago) and Dr. Peter Conrad (Brandeis University) are joining the mentorship committee to provide additional methodological guidance. Together, this committee of mentors has expertise in the emerging legal and ethical challenges in biotechnology; organizational and political barriers in science policy and health policy; and innovative research methods in comparative case study design and program evaluation research. They are eminently qualified and fully committed to assisting Dr. Senier in her multidisciplinary training, research, and career path.

描述（由申请人提供）：这项经过修订的指导研究科学家发展奖（K01）旨在支持威斯康星大学麦迪逊分校助理教授Laura Senier，MPH，PhD的职业。 Senier博士的目标是（1）获得人口遗传学，公共政策分析和涉及新兴遗传技术的道德框架的额外培训；（2）建立一项研究计划，探讨将遗传发现转化为公共卫生政治和计划的技术，政治和道德障碍；（3）成为研究翻译政治的独立研究者。 Senier博士将通过正式的课程，指导协作以及有关州公共卫生政策的实证研究来实现这些目标。该研究计划研究了州卫生机构公共卫生遗传学计划的现代化。具体的目的是（目标1A）描述州卫生机构用来现代化公共卫生遗传学计划的概念模型，组织结构和融资解决方案；（AIM 1B）探讨利益相关者对州公共卫生遗传学计划的范围和适用性的意见和态度；（AIM 2A）通过比较案例研究，确定阻碍或促进遗传学融入公共卫生的关键因素；（AIM 2B）解释公共卫生遗传学计划如何在不同的结构安排下变化，并展示利益相关者的意见如何影响公共卫生遗传学计划。为了回答研究部分审阅者的问题，此修订应用程序阐明了采样策略，并更彻底地解释了定性比较案例研究的分析方法。这项研究将基于通过现场观察，深入访谈和国家公共卫生遗传活动的档案分析收集的原始数据。 Senier博士已招募了一个跨学科的导师委员会，以指导她参加这些培训和研究活动。 Pila Ossorio博士（法学和生物伦理学副教授），Daniel Kleinman博士（社区与环境社会学教授兼主席），Tom Oliver博士（人口健康科学教授）和D. Paul Moberg博士（总监，人口健康研究所）将指导Senier博士在这些工作中。在研究科审查员的建议中，南希·考克斯（Nancy Cox）博士（芝加哥大学）和彼得·康拉德（Peter Conrad）博士（布兰代斯大学）加入了指导委员会，以提供其他方法论指导。这位导师委员会在生物技术方面有新兴的法律和道德挑战方面具有专业知识。科学政策与卫生政策的组织和政治障碍；以及比较案例研究设计和计划评估研究中的创新研究方法。他们非常有资格，并完全致力于协助Senier博士进行她的多学科培训，研究和职业道路。