Surveillance & Treatment of Community Newcomers & Travelers for Trachoma Control

监视

• 批准号: 8723226
• 负责人: SHEILA K WEST
• 金额: $ 122.56万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8723226
• 关键词: Antibiotic Therapy; Area; Azithromycin; Clinical; Clinical Trials; Communities; Confidence Intervals; Control Groups; Data; Disease; Ethiopia; Family; Foundations; Funding; Gambia; Goals; Immigration; Infection; Intervention; Monitor; Pharmaceutical Preparations; Prevalence; Protocols documentation; Randomized; Resource Allocation; Risk; Sentinel; Source; Specific qualifier value; Staging; Study models; System; Testing; Time; Trachoma; arm; community intervention; community planning; design; follow-up; intervention program; pressure; programs; treatment as usual; treatment effect; treatment program

DESCRIPTION (provided by applicant): Infection with C. trachomatis has decreased substantially in trachoma endemic areas following repeated annual mass drug administration with azithromycin, although not as rapidly as anticipated. We propose to conduct a clinical trial to determine the added benefit for communities, which are now at low levels of infection, of a program to identify and treat new families who came after mass treatment, and travelers who return to the community, as they could be the source of re-emergent infection. The proportion of communities who are able to stop mass treatment will be compared in the group of communities randomized to mass treatment plus the newcomer treatment program compared to the communities randomized to mass treatment alone.

描述（由申请人提供）：在用阿奇霉素重复的年度大规模药物给药后，沙眼中流行区的感染已大大降低，尽管不如预期的那么快。我们建议进行一项临床试验，以确定社区的额外收益，这些社区现在处于低水平的感染，该计划的计划，以识别和治疗大规模治疗后出现的新家庭，以及返回社区的旅行者，因为他们可能是重新发射感染的来源。与仅随机分配给群众治疗的社区相比，将在随机分配给大众治疗的社区中比较能够停止大规模治疗的社区的比例。