Genomic and environmental risk factors for cardiometabolic disease in Africans

非洲人心脏代谢疾病的基因组和环境危险因素

基本信息

批准号：
8784175
负责人：
Michele Michele Ramsay
金额：
$ 100万
依托单位：
WITS HEALTH CONSORTIUM (PTY), LTD
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-15 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8784175
关键词：
Address Admixture Africa Africa South of the Sahara African Architecture Bioinformatics Biological Birth Body Composition Body fat Burkina Faso Chronic Disease Communities Community Services Country DNA Data Developing Countries Development Dimensions Disease Disease susceptibility Educational Background Ensure Environmental Risk Factor Epidemiology Epigenetic Process Evaluation Family Fatty acid glycerol esters Female Field Workers Future Genetic Genetic Determinism Genetic Research Genetic Variation Genome Genomics Genotype Ghana HIV HIV Infections Haplotypes Health Health Transition Hip region structure Immigration Individual Infection Informed Consent International Intervention Investigation Kenya Laboratories Link Malaria Metabolic Metabolic Diseases Obesity Phenotype Population Poverty Predisposition Prevalence Public Health Random Allocation Recording of previous events Research Research Infrastructure Research Personnel Risk Rural Rural Community Sampling Scientist Services Site Social Environment South Africa Southern Africa Specimen Staging Structure Tanzania Training and Infrastructure Universities Variant Visceral Vision Wit aged base biobank burden of illness cohort disorder risk environmental change experience genetic variant genome sequencing improved male nutrition education obesity risk programs prospective response skills training social subcutaneous success waist circumference

项目摘要

The long-term vision of the Collaborative Centre (CC) is to build sustainable capacity in Africa for research that leads to an understanding of the interplay between genetic, epigenetic and environmental risk factors for obesity and related cardiometabolic diseases (CMD) in sub-Saharan Africa. The CC will be consolidated under the auspices of the University of the Witwatersrand (Wits) and the International Network for the Demographic Evaluation of Populations and Their Health in Developing Countries (INDEPTH). It will capitalize on the unique strengths of existing longitudinal cohorts, including the urban Soweto and rural Agincourt studies in South Africa (Wits based), and the well established INDEPTH demographic health and surveillance centers in Kenya, Ghana, Tanzania, Burkina Faso and South Africa. The centers offer established infrastructure, trained fieldworkers, long-standing community engagement, and detailed longitudinal phenotypic data, focusing on obesity and cardiometabolic health. Key strengths are harmonized phenotyping across sites, building on strong existing cohorts, and representation of the geographic and social variability of African populations. We aim to: 1. Build sustainable infrastructure (biobanks and laboratories) and capabilities (well characterized population cohorts, genotyping and bioinformatics) for genomic research on the African continent; 2. Understand the genomic architecture of sub-Saharan populations from west, east and south Africa to guide genomic studies (genome sequencing and high throughput SNP and CNV arrays using unrelated individuals and family trios to improve the accuracy of haplotype analyses) and; 3. Investigate the independent and synergistic genomic contributions to body fat distribution (BMI, hip/waist circumference, subcutaneous and visceral fat) in these populations considering the relevant environmental and social contexts (rural/urban communities, quickly transitioning obesity prevalence, differential HIV, TB, and malaria infection histories). We will investigate the effect of obesity and fat distribution on the risk for CMD in the longitudinal cohorts. The CC will draw upon a wide group of highly experienced African scientists and international collaborators to ensure the success of its vision.

协作中心（CC）的长期愿景是在非洲建立可持续的能力，以了解肥胖和相关心脏代谢性疾病（CMD）在撒哈拉以南非洲的遗传，表观遗传和环境风险因素之间的相互作用。 CC将在Witwatersrand大学（WITS）和国际人口统计学评估及其健康国家（Indepth）的国际人口评估网络下进行合并。它将利用现有的纵向人群的独特优势，包括南非的城市索韦托和农村阿金库特研究（基于WITS），以及肯尼亚，加纳，坦桑尼亚，坦桑尼亚，布基纳法索和南非的良好建立的Indepth人口统计健康和监视中心。这些中心提供既定的基础设施，训练有素的野外工作者，长期的社区参与以及详细的纵向表型数据，重点是肥胖和心脏代谢健康。关键优势是在跨站点进行协调的表型，建立在强大的现有人群的基础上，并代表非洲人口的地理和社会变异性。我们的目标是：1。建立可持续的基础设施（生物库和实验室）和能力（人口组成的人群，基因分型和生物信息学），用于非洲大陆的基因组研究； 2。了解来自西部，东部和南非的撒哈拉以南种群的基因组结构，以指导基因组研究（基因组测序以及使用无关的个体和家庭三重点的高吞吐量SNP和CNV阵列，以提高单倍型分析的准确性），并且； 3。研究这些人群中对人体脂肪分布（BMI，髋关节/腰围，皮下脂肪和内脏脂肪）的独立和协同基因组的贡献，这些人群考虑了相关的环境和社会环境（农村/城市/城市社区，迅速过渡肥胖症患病率，差异HIV，TB和疟疾感染）。我们将研究肥胖和脂肪分布对纵向队列中CMD风险的影响。 CC将利用一群经验丰富的非洲科学家和国际合作者，以确保其愿景的成功。