Training Program in Translational Brain Tumor Research

转化脑肿瘤研究培训计划

• 批准号: 8726309
• 负责人: Russell O. Pieper
• 金额: $ 21.24万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8726309
• 关键词: Brain Neoplasms; Research; Training Programs

DESCRIPTION (provided by applicant): The objective of this program is to provide postdoctoral training for individuals interested in pursuing careers in translational brain tumor research. Brain cancer remains among the most deadly of all malignancies, and despite the best efforts of neurosurgeons, neuro-oncologists, and laboratory-based scientists, the average survival of individuals with glioblastoma, the most malignant and common form of brain cancer, remains less than 15 months. Improvements in brain cancer therapy have come slowly, in part because of the relative dearth of individuals trained in a manner that allows them to communicate with both clinicians and lab-based investigators working in the field. This application is a new request for funding to support an existing program that focuses on developing translational brain tumor investigators of the future; individuals who can move seamlessly between clinical and laboratory worlds and in doing so can more effectively contribute to the development of new therapeutic interventions for brain tumors. This application requests support for 3 post-doctoral trainees per year, each of whom will be selected from PhD-level post-doctoral fellows attracted to the labs of the faculty, or from MD or MD/PhD trainees in the UCSF Neuro-Oncology Fellowship Program, or the UCSF Radiation Oncology Residency Program. The best qualified candidates then enter the training program, the core of which consists of the 20 research labs whose work has made the brain tumor community at UCSF one of the most productive and recognizable in the world. Over the course of the two years of support requested, the trainees work with the PIs of these labs to develop and complete meaningful and significant translational brain tumor research projects, and in the process become fluent in laboratory-based and clinical research techniques. At the same time trainees take part in a faculty-led didactic curriculum that is uniquely focused on issues of importance in brain tumors and which allow trainees to develop a common language with which to discuss and understand underlying brain tumor biology, diagnostic and therapeutic modalities, and unresolved problems in the field. Additional courses and training events that encourage effective speaking and writing are also included, and there is an extensive selection of existing courses to help tailor the educational experience of individual trainee's. Finally, evaluation and mentoring mechanisms are included to help ensure success in the program and in attaining future career goals. Although this is a new request for support, the Training Program in Translational Brain Tumor Research at UCSF has an extensive track record of attracting well-qualified individuals, and in successfully preparing investigators who have gone on to lead translational brain tumor research teams at UCSF, nationally, and internationally. The support requested will allow the brain tumor community at UCSF to expand efforts to train effective translational brain tumor investigators, and to ensure that such individuals will continue to be available to assume leadership roles in the fight against brain cancer. RELEVANCE: Adult brain cancer continues to be a significant challenge to clinicians. Although not among the most common organ-specific malignancies, there are over 20,000 cases diagnosed per year, and the mortality rate associated with brain tumors is among the highest of all cancers. Because the prognosis for individuals with the most common types of brain cancer remains poor, it is of critical Importance that new therapies be developed. This proposal requests funds to support a training program that takes promising young investigators and trains them to understand brain tumor biology and therapy as an integrated whole. Investigators trained in this stimulating and comprehensive manner will provide effective, competent leadership for future research efforts aimed at improved treatments and outcomes for brain tumor patients.

描述（由申请人提供）：该计划的目的是为有兴趣从事转化脑肿瘤研究职业的人提供博士后培训。脑癌仍然是所有恶性肿瘤中最致命的，尽管神经外科医生，神经肿瘤学家和基于实验室的科学家尽了最大的努力，但胶质母细胞瘤的个体的平均存活率是胶质母细胞瘤，最恶性和最常见的脑癌，但仍然少于15个月。脑癌治疗的改善速度缓慢，部分原因是接受培训的个体相对缺乏，使他们能够与临床医生和在该领域工作的实验室研究人员进行沟通。该应用程序是一项新的资金请求，以支持现有计划，该计划着重于发展未来的翻译脑肿瘤研究者。可以在临床和实验室世界之间无缝移动的人，而这样做可以更有效地为开发新的治疗干预措施对脑肿瘤的发展。 该申请要求支持每年3名博士后学员，每个人都将从吸引教师实验室的博士学位博士后的博士后研究员，或UCSF Neuro-Onconologology奖学金计划中的MD或MD或MD/MD/PHD培训人员中选出。然后，最好的合格候选人进入培训计划，其核心由20个研究实验室组成，其工作使UCSF的脑肿瘤社区成为了世界上最有生产力和最知名的。在要求的两年支持的过程中，学员与这些实验室的PI一起开发并完成了有意义且重要的转化脑肿瘤研究项目，并且在这一过程中会流利地利用实验室和临床研究技术。同时，学员参加了由教师领导的教学课程，该课程专注于脑肿瘤的重要性问题，并允许受训者开发一种通用语言，以讨论和理解潜在的脑肿瘤生物学，诊断和治疗方式，以及该领域中未解决的问题。还包括鼓励有效口语和写作的其他课程和培训活动，并且有大量的现有课程选择，以帮助定制个人学员的教育经验。最后，包括评估和指导机制，以帮助确保该计划的成功并实现未来的职业目标。 尽管这是一个新的支持请求，但UCSF转化脑肿瘤研究的培训计划具有吸引合格的个人的广泛记录，并在成功地为领导UCSF的转化转化脑肿瘤研究团队的调查人员做好准备。所需的支持将使加州大学洛杉矶斯夫（UCSF）的脑肿瘤界能够扩大训练有效的翻译脑肿瘤研究人员的努力，并确保此类人将继续可用来在对抗脑癌的斗争中发挥领导作用。 相关性：成人脑癌仍然是临床医生的重大挑战。尽管不是最常见的器官特异性恶性肿瘤之一，但每年有超过20,000例诊断出的病例，与脑肿瘤相关的死亡率是所有癌症中最高的。由于对脑癌类型最常见的个体的预后仍然很差，因此开发新疗法至关重要。该提案要求资金支持一项培训计划，该计划采用有前途的年轻研究人员，并培训他们以理解脑肿瘤生物学和治疗是整体的整体。接受这种刺激性和全面方式培训的调查人员将为未来的研究工作提供有效的，有效的领导力，旨在改善脑肿瘤患者的治疗和结果。