Psychobiology of Racial Minority Stress and Cellular Aging

少数种族压力和细胞衰老的心理生物学

• 批准号: 8723035
• 负责人: H. David Chae
• 金额: $ 11.61万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8723035
• 关键词: Academic Training; Address; Affective; African American; Age-Years; Aging; Area; Award; Basic Science; Behavioral; Behavioral Sciences; Biological; Biological Assay; Biological Factors; Biological Markers; Biological Sciences; Biology; Cell Aging; Chronic Disease; Cognitive; Cohort Studies; Collection; Commit; Complement; Coronary artery; Coronary heart disease; Data; Data Analyses; Data Collection; Data Set; Deterioration; Development; Development Plans; Dimensions; Disease; Disease Outcome; Educational workshop; Elderly; Electrocardiogram; Endocrine; Endocrinology; Ensure; Epidemiologic Methods; Epidemiologic Studies; Epidemiology; Equation; Fasting; Foundations; Gender; Goals; Grant; Health; Health Status; Health behavior; Health education; Heart; Hour; Hydrocortisone; Inflammation; Interleukin-6; Investments; Knowledge; Lead; Length; Leukocytes; Life Cycle Stages; Life Expectancy; Life Stress; Link; Manuscripts; Measures; Medical Records; Mental Depression; Mental Health; Mentorship; Methods; Minority; Minority Groups; Modeling; Molecular Biology; Neurosciences; Norepinephrine; Outcome; Participant; Pathway interactions; Physiological; Plant Roots; Population; Positioning Attribute; Process; Prospective Studies; Psychological Factors; Psychology; Psychoneuroimmunology; Psychosocial Factor; Psychosocial Stress; Public Health; Public Health Schools; Publications; Questionnaires; Race; Reading; Recording of previous events; Research; Research Ethics; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Sampling; Science; Shapes; Social Sciences; Socialization; Sociology; Solid; Source; Stress; System; TNF gene; Telomere Maintenance; Telomere Shortening; Testing; Training; Universities; Urine; Venous blood sampling; Work; Writing; age related; base; behavioral health; biological adaptation to stress; career; career development; coping; early onset; experience; heuristics; holistic approach; illness length; inflammatory marker; innovation; insight; longitudinal analysis; men; middle age; minority health; mortality; novel marker; premature; professor; programs; prospective; psychobiologic; psychobiology; psychologic; psychosocial; racial discrimination; research and development; response; responsible research conduct; skills; social; stressor; success; symposium; telomere; young adult

DESCRIPTION (provided by applicant): Dr. H. David Chae, Sc.D., M.A., is an Assistant Professor in the Department of Behavioral Sciences and Health Education at the Rollins School of Public Health, Emory University. He has an established history of conducting research on social and psychological determinants of health in racial minority populations. He has consistently applied his expertise and diverse academic training, in psychology, sociology, and public health, to examine factors associated with racial minority status and health. More specifically, his research has focused on racial discrimination and dimensions of racial identity i relation to mental health, health behaviors, as well as physical disease outcomes associated with aging among racial minority populations. The scope of Dr. Chae's work on psychosocial factors associated with racial minority health would be considerably enriched through additional training aimed at gaining a broad foundation of knowledge on psychobiological stress pathways, and more in-depth knowledge on telomere maintenance and function. Acquiring this solid background would allow him to conduct epidemiologic studies integrating biomarkers of inflammation and endocrine stress markers, in addition to research examining leukocyte telomere length (LTL), a novel marker of cumulative life stress and systemic aging at the physiologic level. Examining LTL may be particularly informative in studying the impact of racial minority stress which is experienced across the life- course. These activities are complemented by additional training in advanced biostatistical modeling (latent variable analysis), which add to his existing skills in the use of traditional epidemiologic methods. Latent class/profile analysis (LCA/LPA) will be used to empirically derive groups of participants distinguished along physiologic indicators of stress, and explicitly applies the knowledge gained in psychobiological stress mechanisms. Structural equation modeling (SEM) will be used to model hypothesized pathways linking racial discrimination and LTL. Additional career development activities emphasized in this application include training in the responsible conduct of research and continued professional development, through presentations at scientific conferences, the publication of manuscripts, and the development and submission of an R01 application that builds upon the knowledge that he gains, as well as findings from the proposed research. These activities are facilitated through a combination of mentorship by experts, didactic coursework, workshops, attendance of scientific conferences, and a directed program of reading. The training and development plan includes introductory courses in aging, stress biology, psychoneuroimmunology, and behavioral endocrinology; workshops and conferences specifically relevant to psychobiological pathways associated with aging and telomere maintenance and function; courses and workshops on latent variable analysis and statistical programming; as well as those focused on research ethics and grant writing. Integrating this substantive and methodological knowledge into his existing work represents an important step towards developing a trans- disciplinary research portfolio that spans the social and basic sciences; and his career goal to lead collaborative, multi-disciplinary teams including those with expertise in diverse fields, including epidemiology, sociology, psychology, neuroscience, and molecular biology in studying racial disparities in aging. Each of the training and development activities included in this application are applied towards the research plan, which involves examining data from three studies - the Heart and Soul Study (HSS); the Coronary Artery Risk Development in Young Adults Study (CARDIA); and the Bay Area Heart Health Study (BAHHS). Analysis of these three datasets is aimed at: (1) identifying inflammatory markers and endocrine markers of stress that cluster with LTL and subsequently predict aging-related health outcomes, thereby providing evidence for biological mechanisms impacting LTL and disease processes; (2) examining whether racial discrimination is associated with LTL, and identifying psychological and biological factors that may be on the pathway linking this exposure and outcome; and (3) exploring other psychosocial factors associated with racial minority status, such as affective and cognitive responses to racial discrimination, coping, racial identity, in-group racial bias, and racial socialization, which may also impact LTL and aging-related disease outcomes. Each aspect of the training component of this application is applied in innovative ways to the research plan; and together they represent a holistic approach to studying factors and pathways associated with aging-related disease outcomes. Emory University serves as an ideal base to achieve the career development and research objectives outlined in this application, given its history of excellence in both the social and biological sciences, and emphasis on inter-disciplinary educational programs. Emory University commits substantial institutional investment, including financial and intellectual resources to ensure the success of this application and progress towards becoming an independent investigator. A specific objective of this application is to submit an R01 grant focused on identifying risk factors associated with LTL among racial minority groups, by applying the broad knowledge on the psychobiology of aging and training in the collection, analysis, and interpretation of LTL data; and the research findings obtained from this application. Through this award, Dr. Chae will be well- positioned to achieve his goal of developing a research agenda that bridges social epidemiology, psychology, and biology in understanding racial disparities in aging-related diseases.

描述（由申请人提供）：H. David Chae 博士，科学博士、文学硕士，是埃默里大学罗林斯公共卫生学院行为科学和健康教育系的助理教授。他在少数族裔人口健康的社会和心理决定因素方面有着悠久的研究历史。他始终如一地运用自己在心理学、社会学和公共卫生领域的专业知识和多样化的学术训练来研究与少数族裔地位和健康相关的因素。更具体地说，他的研究重点是种族歧视和种族认同维度与心理健康、健康行为以及与少数族裔人口老龄化相关的身体疾病结果的关系。 通过旨在获得有关心理生物学压力途径的广泛知识基础以及有关端粒维护和功能的更深入知识的额外培训，Chae 博士在与少数族裔健康相关的心理社会因素方面的工作范围将大大丰富。获得这一扎实的背景将使他能够进行整合炎症生物标志物和内分泌应激标志物的流行病学研究，此外还可以研究白细胞端粒长度（LTL），这是生理水平上累积生活压力和全身衰老的新标志物。检查LTL对于研究一生中经历的少数族裔压力的影响可能特别有用。这些活动辅以高级生物统计模型（潜变量分析）方面的额外培训，这增加了 他现有的使用传统流行病学方法的技能。潜在类别/概况分析（LCA/LPA）将用于凭经验得出根据压力生理指标区分的参与者群体，并明确应用在心理生物学压力机制中获得的知识。结构方程模型 (SEM) 将用于对种族歧视和 LTL 之间的假设路径进行建模。本申请中强调的其他职业发展活动包括通过在科学会议上的演讲、出版手稿以及基于所获得的知识开发和提交 R01 申请，进行负责任的研究行为和持续专业发展的培训，以及拟议研究的结果。这些活动是通过专家指导、教学课程、研讨会、参加科学会议和定向阅读计划相结合来促进的。培训和发展计划包括衰老、应激生物学、心理神经免疫学和行为内分泌学等入门课程；特别与衰老和端粒维持和功能相关的心理生物学途径相关的研讨会和会议；关于潜变量分析和统计规划的课程和讲习班；以及那些专注于研究伦理和资助写作的人。将这种实质性和方法论知识融入到他现有的工作中，代表着朝着开发涵盖社会科学和基础科学的跨学科研究组合迈出了重要一步；他的职业目标是领导协作、多学科团队，包括流行病学、社会学、心理学、神经科学和分子生物学等不同领域的专业知识，研究老龄化中的种族差异。 本申请中包含的每项培训和发展活动均应用于研究计划，其中涉及检查三项研究的数据：心与灵魂研究 (HSS)；年轻人冠状动脉风险发展研究（CARDIA）；和湾区心脏健康研究 (BAHHS)。对这三个数据集的分析旨在：（1）识别与LTL聚集的炎症标记物和应激内分泌标记物，并随后预测与衰老相关的健康结果，从而为影响LTL和疾病过程的生物机制提供证据； (2) 检查种族歧视是否与 LTL 有关，并确定可能在连接这种暴露和结果的途径上的心理和生物因素； (3) 探索与少数族裔身份相关的其他心理社会因素，例如对种族歧视、应对、种族身份、群体内种族偏见和种族社会化的情感和认知反应，这些因素也可能影响 LTL 和衰老相关疾病的结果。该应用程序的培训部分的每个方面都以创新的方式应用于研究计划；它们共同代表了研究与衰老相关疾病结果相关的因素和途径的整体方法。鉴于埃默里大学在社会科学和生物科学方面的卓越历史以及对跨学科教育计划的重视，埃默里大学是实现本申请中概述的职业发展和研究目标的理想基地。埃默里大学投入了大量的机构投资，包括财政和智力资源，以确保本申请的成功以及成为独立研究者的进展。本申请的具体目标是提交 R01 拨款，重点是通过应用衰老心理生物学的广泛知识以及收集、分析和解释 LTL 数据的培训，识别少数族裔群体中与 LTL 相关的风险因素；以及研究结果 从该应用程序获得。通过该奖项，Chae 博士将能够很好地实现他的目标，即制定一项研究议程，将社会流行病学、心理学和生物学联系起来，以了解与衰老相关的疾病的种族差异。

项目成果

Implicit racial bias as a moderator of the association between racial discrimination and hypertension: a study of Midlife African American men.

• DOI: 10.1097/psy.0b013e3182733665
• 发表时间: 2012-11
• 期刊: Psychosomatic medicine
• 影响因子: 3.3
• 作者: Chae DH;Nuru-Jeter AM;Adler NE
• 通讯作者: Adler NE

Socioeconomic Status, Financial Strain, and Leukocyte Telomere Length in a Sample of African American Midlife Men.

非裔美国中年男性样本的社会经济地位、财务压力和白细胞端粒长度。

• DOI: 10.1007/s40615-017-0388-3
• 发表时间: 2018
• 期刊: Journal of racial and ethnic health disparities
• 影响因子: 3.9
• 作者: Schrock,JoshuaM;Adler,NancyE;Epel,ElissaS;Nuru-Jeter,AmaniM;Lin,Jue;Blackburn,ElizabethH;Taylor,RobertJoseph;Chae,DavidH
• 通讯作者: Chae,DavidH

The Role of Racial Identity and Implicit Racial Bias in Self-Reported Racial Discrimination: Implications for Depression Among African American Men.

• DOI: 10.1177/0095798417690055
• 发表时间: 2017
• 期刊: The Journal of black psychology
• 作者: Chae DH;Powell WA;Nuru-Jeter AM;Smith-Bynum MA;Seaton EK;Forman TA;Turpin R;Sellers R
• 通讯作者: Sellers R