Core B - Statistical and Data Management

核心 B - 统计和数据管理

• 批准号: 9703470
• 负责人: Michael Malek-Ahmadi
• 金额: $ 17.02万
• 依托单位: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9703470
• 关键词: Address; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Bioinformatics; Cellular Neurobiology; Chicago; Clinical; Cognitive; Data; Data Analyses; Data Analytics; Data Set; Databases; Diagnosis; Disease Progression; Elderly; Ensure; Exclusion Criteria; Goals; Laboratories; Libraries; Link; Mission; Molecular; Molecular Neurobiology; Network-based; Neurobiology; Pathologic; Program Research Project Grants; Research; Research Design; Research Personnel; Research Project Grants; Resources; Specific qualifier value; Statistical Data Interpretation; Tissue Sample; Tissues; basal forebrain; case-based; cholinergic; data archive; data management; experience; human tissue; mild cognitive impairment; pre-clinical; religious order study; statistics; success

Core B: Abstract The overall goal of the Statistics and Data Management Core (Core B) is to continue providing the computational and analytic resources to support the overall Program Project Grant (PPG) mission of elucidating the molecular neurobiology of mild cognitive impairment (MCI). More specifically, Core B will assist with study design, tissue selection, data management, statistical analysis, and results interpretation to ensure the success of each PPG investigator. Specifically, the core will provide data management linking existing clinical and neuropathological data from the Rush Religious Orders Study (RROS) housed in the Rush Alzheimer’s Disease Core Center (RADCC) with the cellular and molecular findings from the three proposed Program Project Grant (PPG) components. To accomplish this, Core B will: Extract and retrieve relevant data from the RROS clinical and neuropathological databases; expand, document, and maintain a PPG data library and merge RROS data with data generated by the PPG research projects for statistical analysis. In addition, Core B will identify eligible cases based upon inclusion/exclusion criteria specified by the PPG while maintaining blinding to clinical and pathological diagnoses. Finally, provide statistical support for study design, prepare all analytic data sets across projects, perform statistical analyses as needed, and assure statistical accuracy in interpretation and presentation of results. The statistical research team is experienced in the conduct of neuropathological studies involving human tissue samples.

核心B：摘要 统计和数据管理核心（核心B）的总体目标是继续提供 支持总体计划项目赠款（PPG）的计算和分析资源 阐明轻度认知障碍分子神经生物学（MCI）的任务。更多的 具体而言，核心B将有助于研究设计，组织选择，数据管理，统计 分析和结果解释以确保每个PPG研究者的成功。具体来说， 核心将提供链接现有临床和神经病理学数据的数据管理 Rush宗教命令研究（RROS）安置在阿尔茨海默氏病核心中心 （RADCC）与三个提议的计划项目授予的细胞和分子发现 （PPG）组件。为此，核心B将：从 RROS临床和神经病理学数据库；扩展，记录和维护 PPG数据库并将RROS数据与PPG研究项目生成的数据合并 统计分析。此外，核心B将根据包含/排除确定合格案例 PPG指定的标准同时保持对临床和病理诊断的视而不见。 最后，为研究设计提供统计支持，准备跨项目的所有分析数据集， 根据需要进行统计分析，并确保解释的统计准确性 结果的呈现。统计研究团队在行为方面经验丰富 涉及人体组织样本的神经病理学研究。