Component III: Stress Related College Drinking: Learned and Genetic Vulnerabiliti

第三部分：与压力相关的大学饮酒：习得性和遗传性脆弱性

• 批准号: 8374668
• 负责人: HOWARD TENNEN
• 金额: $ 27.39万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8374668
• 关键词: Address; Affect; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohols; Behavioral Genetics; Belief; Candidate Disease Gene; DNA; Data Collection; Dependence; Disease susceptibility; Environment; Etiology; Event; Expectancy; Family; Genes; Genetic; Genetic Polymorphism; Genetic Predisposition to Disease; Genotype; Goals; Individual; Internet; Intervention; Learning; Life; Link; Measures; Memory; Modeling; Motivation; Outcome; Pattern; Population; Preventive; Process; Reporting; Research; Risk Factors; Role; Saliva; Serotonin; Stress; Symptoms; System; Techniques; Time; alcohol effect; base; college drinking; coping; drinking; drinking behavior; experience; genetic risk factor; innovation; response; serotonin transporter; social; stressor; university student

Component III - Stress-Related College Drinking: Learned and Genetic Vulnerabilities The proposed study will examine simultaneously the roles of learned and genetic risk factors for college student drinking in response to stress- and affect-related triggers. Specifically, we will evaluate how socially-learned vulnerabilities, such as beliefs and motivations regarding the calming effects of drinking, as well as genetic vulnerabilities, including genes related to serotonin function, serve as diatheses for engaging in stress- and negative affect-related drinking (SNAD). Our proposed study will model SNAD processes at two levels. At the MACRO-LEVEL, we will examine how learned and genetic vulnerabilities interplay with major life stressors (i.e., early family environment, traumatic encounters, and negative life events) to influence average drinking outcomes and abuse/dependent symptoms among college students. At the MICROLEVEL, we will examine how learned and genetic vulnerabilities interplay with daily stressors and negative affect states to influence drinking, alcohol abuse/dependence symptoms, and coping-related drinking on a day-to-day basis among college students. To address these aims, we will employ an innovative Internet reporting system to (a) administer one-time measures of social learning risk factors, major life stressors, and average alcohol abuse/dependence symptoms and (b) track daily stress, affect, and alcohol use during a 30-day period among 1600 college students. This close to real-time data collection technique will minimize memory biases, thereby providing robust and reliable reports of daily alcohol use and related experiences. Saliva will be collected and DNA isolated and genotyped for carefully selected candidate genes, including the serotonin transporter gene-linked polymorphism (5-HTTLPR) and other genes identified as potentially important risk factors for engaging in stress-related drinking. The proposed study is the first to examine how social learning and genetic vulnerabilities together contribute to both drinking levels in response to major life stressors and day-to-day drinking patterns in response to proximal daily stressors. This project will provide greater understanding of the factors that engender maladaptive drinking behaviors in a college-student population, which will potentially inform preventive and treatment interventions.

第三部分——与压力相关的大学饮酒：习得和遗传的脆弱性 拟议的研究将同时研究习得和遗传风险因素对大学生饮酒对压力和情感相关触发因素的影响。具体来说，我们将评估社会习得的脆弱性（例如关于饮酒镇静作用的信念和动机）以及遗传脆弱性（包括与血清素功能相关的基因）如何成为参与与压力和负面情绪相关的饮酒的素质（SNAD）。我们提出的研究将在两个层面上模拟 SNAD 过程。在宏观层面，我们将研究习得性和遗传性脆弱性如何与主要的相互作用。 生活压力因素（即早期家庭环境、创伤经历和消极生活事件）影响大学生的平均饮酒结果和虐待/依赖症状。在微观层面，我们将研究后天和遗传的脆弱性如何与日常压力源和负面情绪状态相互作用，从而影响大学生的日常饮酒、酒精滥用/依赖症状以及应对相关饮酒。为了实现这些目标，我们将采用创新的互联网报告系统（a）管理社会学习风险因素、主要生活压力源和平均酒精滥用/依赖症状的一次性测量，以及（b）跟踪日常压力、情感和酒精依赖症状。 1600 名大学生在 30 天内的饮酒情况。这种接近实时的数据收集技术将最大限度地减少记忆偏差，从而提供日常饮酒和相关经历的稳健可靠的报告。 将收集唾液，分离 DNA，并针对精心挑选的候选基因进行基因分型，包括血清素转运蛋白基因连锁多态性 (5-HTTLPR) 和其他被确定为与压力相关的饮酒的潜在重要危险因素的基因。这项拟议的研究首次探讨了社会学习和遗传脆弱性如何共同影响应对主要生活压力源的饮酒水平和应对近期压力源的日常饮酒模式。该项目将更好地了解导致大学生群体适应不良饮酒行为的因素，这将有可能为预防和治疗干预措施提供信息。