Large Database Research for Cancer Prevention & Control

癌症预防的大型数据库研究

• 批准号: 6835211
• 负责人: GREGORY S. COOPER
• 金额: $ 13.48万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6835211
• 关键词: Medicare /Medicaid; antineoplastics; breast neoplasms; cancer prevention; cancer registry /resource; colorectal neoplasms; endoscopy; gastrointestinal imaging /visualization; gastrointestinal neoplasms; health insurance; human data; managed care; mass screening; medical records; neoplasm /cancer; neoplasm /cancer epidemiology; neoplasm /cancer therapy; pancreas neoplasms; prostate neoplasms; rectum neoplasms

The Candidate, a gastroenterologist/health services researcher has developed a focused research program in cancer prevention and control, primarily through the use of large population-based databases. In addition, he has mentored several trainees and junior faculty at different levels of training. However, because of time and budgetary restraints, his ability to provide data and methodological support to junior researchers is increasingly limited. In addition, he has been unable to expand his research focus to different cancer sites and other content areas, including pharmacoepidemiology. The proposed Established Investigator Award in Cancer Prevention, Control Behavioral and Population Research will assist the Candidate in fulfilling his long-term career goals. These include to evaluate the effectiveness of commonly performed screening, treatment and surveillance procedures in routine clinical practice; determine the accuracy, completeness and appropriateness of alternative methods to measure cancer screening, surveillance, and therapy; and develop a critical mass of cancer prevention and control researchers. The proposal will enable the Candidate to use data sources with which has considerable experience to study other clinically relevant issues. He will investigate the recognition of pre-malignant conditions of the esophagus and its impact on patient outcome, as well as the frequency of use and clinical impact of endoscopic ultrasonography on the diagnosis and treatment of patients with gastrointestinal cancer. In addition, we will develop expertise in the use of pharmacy databases to study the protective effects of non-steroidal anti-inflammatory drugs on colorectal cancer incidence. The resources of this award will also enable aim to develop an infrastructure that will provide the necessary data and research support to train junior investigators in the use of large databases to conduct cancer related health services research.

候选人是胃肠病学家/卫生服务研究人员，主要通过使用大型基于人群的数据库，开发了一项针对癌症预防和控制的重点研究计划。此外，他还指导了几名学员和初级教师，以不同的培训水平。但是，由于时间和预算限制，他为初级研究人员提供数据和方法学支持的能力越来越有限。此外，他无法将研究重点扩展到包括药物ePidemiology在内的不同癌症网站和其他内容领域。拟议的癌症预防，控制行为和人口研究的既定研究者奖将有助于候选人实现他的长期职业目标。其中包括评估常规临床实践中常见筛查，治疗和监视程序的有效性；确定替代方法的准确性，完整性和适当性，以测量癌症筛查，监测和治疗；并发展大量的癌症预防和控制研究人员。该提案将使候选人能够使用具有丰富经验的数据源来研究其他临床相关问题。他将研究食管前主教疾病的识别及其对患者预后的影响，以及内窥镜超声检查对胃肠道癌患者诊断和治疗的使用频率和临床影响。此外，我们将在使用药房数据库中发展专业知识来研究非甾体类抗炎药对结直肠癌发病率的保护作用。该奖项的资源还将促进建立基础设施，该基础设施将提供必要的数据和研究支持，以培训初级调查人员使用大型数据库来进行癌症相关的卫生服务研究。