NINDS Stroke Trials Network - Regional Coordinating Center

NINDS 中风试验网络 - 区域协调中心

• 批准号: 8739334
• 负责人: Mustapha Ahmad Ezzeddine
• 金额: $ 38万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8739334
• 关键词: Acute; Adult; Affect; African American; Aging; Area; Asians; Caring; Catchment Area; Cause of Death; Censuses; Childhood; Childhood stroke; Clinical; Clinical Management; Clinical Research; Clinical Trials Design; Collaborations; Commit; Complement; County; Critical Care; Data; Dedications; Diagnostic; Discipline; Disease; Effectiveness; Emergency Situation; Emergency treatment; Enrollment; Female; Fostering; Funding; Future; Hispanics; Hospitals; Image; Incubators; Individual; Inpatients; Institution; Interventional radiology; Leadership; Learning; Marketing; Medical; Mentorship; Minnesota; Mission; Modeling; National Institute of Neurological Disorders and Stroke; Native Americans; Neurological emergencies; Neurology; North Dakota; Outcome; Patients; Performance; Phase; Population; Prevention; Prevention education; Principal Investigator; Public Health; Qualifying; Recording of previous events; Recovery; Recruitment Activity; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Resources; Rural; Site; South Dakota; Standardization; Stroke; Study Subject; System; Therapeutic; Time; Training; Translations; Trust; Universities; Wisconsin; Work; clinical research site; demographics; disability; experience; implementation trial; improved; medical schools; medical specialties; member; mortality; nervous system disorder; neurosurgery; organizational structure; pre-clinical; programs; public health relevance; racial and ethnic; success; treatment trial

DESCRIPTION (provided by applicant): Stroke is a common neurological disease and is a growing major public health problem. Although mortality is declining, it remains the number 4 cause of death in the U.S. It is still a major cause of disability, and is expected to significantl grow in number of affected individuals with aging of the population. The mission of NINDS is to reduce the burden of neurological disease, such as stroke. NINDS funded stroke trials have often suffered from long start up time and delays in completing the research. A better way of conducting stroke clinical research on a larger scale is needed. The main objective of this application is to be a Regional Coordinating Stroke Center (RCC) in the NINDS Stroke Trials Network. The purpose of the network is to accelerate and facilitate translation of scientific advancement in stroke treatment, prevention and recovery. Performing such research through the network will introduce a higher degree of efficiency and effectiveness in conducting the trials. The infrastructure to conduct stroke research will not need to be reorganized with every new trial. Trials will be initiated and completed faster. Standardization of clinical and biologica data will also be useful for future work. Enhanced collaboration will result from such a network, and will function as an incubator for trial design. In addition, the network will broaden access to subjects in the acute phase, prevention, and recovery periods. The University of Minnesota and its stroke program are uniquely qualified to serve a Regional Coordinating Center. It has access to a broad set of academic researchers relevant for this field, with depth in various domains of clinical research. It can also draw on the experience of implementing research network, as a current member in the NINDS Neurological Emergency Research Network (NETT). The leaders for this application and of the program are experienced in stroke clinical research, research through networks, and are experts in the subject matter. The various specialties needed to collaborate for successful implementation of the trials are already aligned administratively in collaborative units beyond traditional departments. Overall, the current stroke program at the University of Minnesota is an excellent candidate for leading an RCC.

描述（由申请人提供）：中风是一种常见的神经系统疾病，是日益严重的公共卫生问题。尽管死亡率正在下降，但它仍然是美国第四死亡原因，但它仍然是残疾的主要原因，预计在人口老龄化的受影响的个体中有显着增长。 Ninds的使命是减轻神经系统疾病的负担，例如中风。 NINDS资助的中风试验通常会遭受较长的启动时间和完成研究的延误。需要更大范围的更好的方法进行中风临床研究。该应用程序的主要目的是成为Ninds中风试验网络中的区域协调中风中心（RCC）。该网络的目的是加速和促进中风治疗，预防和恢复中科学进步的转化。通过网络进行此类研究将在进行试验时引入更高程度的效率和有效性。进行中风研究的基础设施无需在每项新试验中重组。试验将启动并更快地完成。临床和生物学数据的标准化也将用于将来的工作。这种网络将造成增强的协作，并将充当试验设计的孵化器。此外，网络将扩大对 急性阶段，预防和恢复期的受试者。明尼苏达大学及其中风计划具有独特的资格，可以为区域协调中心服务。它可以访问与该领域相关的广泛学术研究人员，在临床研究的各个领域中具有深度。作为NINDS神经系统紧急研究网络（NETT）的现任成员，它还可以利用实施研究网络的经验。该应用程序和该计划的领导者在中风临床研究，通过网络研究中经验丰富，并且是该主题的专家。成功实施试验所需的各种专业已经在传统部门以外的协作单位上进行行政状态。总体而言，明尼苏达大学目前的中风计划是领导RCC的绝佳候选人。