SEPA III: The Effectiveness Trial

SEPA III：有效性试验

基本信息

批准号：
8352598
负责人：
Nilda P Peragallo Montano
金额：
$ 21.18万
依托单位：
UNIVERSITY OF MIAMI CORAL GABLES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-12-01 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8352598
关键词：
AIDS prevention ARHGEF5 gene Accounting Acculturation Acquired Immunodeficiency Syndrome Address Age Alcohol consumption Behavior Cause of Death Centers for Disease Control and Prevention (U.S.)Centers of Research Excellence Characteristics Chlamydia trachomatis Communication Communities Community Practice Conflict (Psychology)County Dependency Diagnosis Economics Effectiveness Evaluation Evidence based practice Family Florida Foundations Frequencies Gender Goals HIV HIV Infections Health Health Personnel Health education High Risk Woman Hispanics Human Resources Incidence Inequality Intervention Knowledge Life Linear Models Logistic Regressions Low income Mediating Mediation Men&apos s Role Mexican Minority Neisseria gonorrhoeae Not Hispanic or Latino Nurses&apos Health Study Partner Communications Population Prevention Prevention strategy Preventive Intervention Problem Solving Public Health Puerto Rican Randomized Randomized Controlled Trials Readiness Recruitment Activity Relative (related person)Religious Belief Reporting Research Research Design Risk Risk Behaviors Risk Reduction Sampling School Nursing Self Care Services Sex Behavior Sexually Transmitted Diseases Site Syphilis Testing Time Translating Universities Waiting Lists Woman Women&apos s Health Women&apos s Role community setting condoms effectiveness trial evidence base health disparity improved intervention effect intimate partner violence minority health motherhood novel peer research study response sex sexually active skills training therapy design violence prevention

项目摘要

The proposed study's overarching goal is to reduce the ethnic disparities in HIV between Hispanic and non-Hispanic women. This goal will be accomplished by two aims: Aim 1 is to establish a novel and effective partnership to improve minority health by integrating SEPA (i.e., Salud, Educacion, Prevencion y Autocuidado; Health, Education, Prevention and Self-Care) an evidenced based, HIV preventive intervention into community setting while assessing agency and facilitator characteristics and readiness for practice improvement, implementation, fidelity, and sustainability; and Aim 2 is to evaluate the effectiveness of SEPA to increase HIV prevention behaviors and to reduce the incidence of STIs for Hispanic women when delivered in a real-world setting by community agency personnel. 300 Spanish-speaking Hispanic women between the ages of 18 and 50 who are sexually active will be recruited from one of four Miami-Dade County Public Health Department sites and randomized to either SEPA or a Wait-List Control condition. SEPA has been evaluated and found to be efficacious in two separate randomized controlled trials. In the first study (Peragallo et al., 2005), SEPA was shown to be efficacious relative to a Wait List Control condition in increasing the frequency of condom use, increasing partner communication regarding sex, and increasing HIV knowledge. In the second study (Peragallo et al., 2011), SEPA was efficacious (relative to Wait List Control) in reducing the incidence of STIs, in increasing the frequency of condom use, increasing partner communication, reducing intimate partner violence, and decreasing alcohol use. Partner communication regarding sex mediated the effects of the intervention on frequency of condom use. Hierarchical Linear Modeling (HLM) will be used to test (HI a): SEPA will be more effective relative to Wait List Control in reducing unprotected sexual behavior (defined as frequency of condom use in the past 90 days) over time. Logistic Regression will be used to test (H2a): SEPA will be more effective relative to Wait List Control in reducing STI incidence (specifically, the incidence of Neisseria gonorrhea. Chlamydia trachomatis, and Syphilis). Additionally, HLM and logistic regression, respectively, will be used to determine whether (H1b): The effect of SEPA on unprotected sexual behavior will be partially mediated by improvements in sexual communication with partner; and (H2b) The effect of SEPA on STI incidence will be partially mediated by improvements in sexual communication with partner and reductions in unprotected sexual behavior.

拟议研究的总体目标是减少西班牙裔和非西班牙裔女性在艾滋病毒方面的种族差异。这一目标将通过两个目标来实现：目标 1 是通过整合 SEPA（即 Salud、Educacion、Prevencion y Autocuidado；健康、教育、预防和自我保健）建立一种新颖且有效的伙伴关系，以改善少数群体的健康。 , 对社区环境进行艾滋病毒预防干预，同时评估机构和促进者的特征以及实践改进、实施、忠诚度和可持续性的准备情况；目标 2 是评估社区机构人员在现实环境中实施 SEPA 的有效性，以增加西班牙裔妇女的艾滋病毒预防行为并减少性传播感染的发病率。将从迈阿密戴德县公共卫生部门的四个站点之一招募 300 名年龄在 18 岁至 50 岁之间、性活跃的讲西班牙语的西班牙裔女性，并随机分配到 SEPA 或等待名单控制条件。 SEPA 已在两项独立的随机对照试验中进行了评估并发现其有效。在第一项研究中（Peragallo 等人，2005 年），SEPA 被证明相对于等待名单控制条件在增加安全套使用频率、增加伴侣关于性的沟通以及增加艾滋病毒知识方面是有效的。在第二项研究中（Peragallo 等人，2011 年），SEPA 在减少性传播感染的发病率、增加安全套使用频率、增加性伴侣沟通、减少亲密伴侣暴力和减少饮酒方面有效（相对于等待名单控制）使用。伴侣关于性的沟通调节了干预措施对安全套使用频率的影响。将使用分层线性模型 (HLM) 来测试 (HI a)：随着时间的推移，SEPA 相对于等待名单控制在减少无保护性行为（定义为过去 90 天内使用安全套的频率）方面将更加有效。将使用 Logistic 回归来检验 (H2a)：SEPA 相对于等待名单控制在降低 STI 发病率（特别是淋病奈瑟菌、沙眼衣原体和梅毒的发病率）方面将更有效。此外，HLM 和逻辑回归将分别用于确定是否 (H1b)： SEPA 对无保护性行为的影响将部分通过与伴侣性沟通的改善来调节； (H2b) SEPA 对性传播感染发病率的影响将部分通过与伴侣性沟通的改善和无保护性行为的减少来调节。