A Microneedle Array System for Transcutaneous Nerve Mapping

用于经皮神经标测的微针阵列系统

• 批准号: 8647434
• 负责人: James Ross
• 金额: $ 55.49万
• 依托单位: AXION BIOSYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8647434
• 关键词: 3-Dimensional; Algorithms; Area; Charge; Clinical; Computer software; Custom; Data; Development; Diagnosis; Diagnostic; Disease; Electrocardiogram; Electrodes; Electromyography; Electronics; Face; Foundations; Gel; Goals; Housing; Human; Individual; Intraoperative Monitoring; Maps; Medical; Microelectrodes; Microfabrication; Monitor; Morphologic artifacts; Needles; Nerve; Neural Conduction; Neuromuscular Diseases; Noise; Pain; Patients; Peripheral Nerves; Phase; Physicians; Preparation; Process; Research; Research Personnel; Research Project Grants; Resolution; Retinal blind spot; Signal Transduction; Skin; Sterility; Stimulus; Surface; System; Techniques; Technology; Therapeutic; Time; Training; Tweens; Variant; base; cost effective; data acquisition; density; electric impedance; flexibility; improved; innovation; instrument; manufacturing process; miniaturize; neural prosthesis; novel; patient safety; public health relevance; relating to nervous system; response; signal processing

PROJECT SUMMARY The proposed study combines novel electronics and microfabrication techniques to create a non-invasive, research platform for targeted stimulation and characterization of human peripheral nerves. This Phase II proposal involves two significant developments for high-resolution peripheral nerve interfacing. Aim 1 will develop high-resolution and low-noise skin surface electrode arrays. Each electrode within the array will consist of cost-effective micropatterned needles, which significantly decrease electrode impedance by pain- lessly piercing the topmost layer of skin, thereby providing high spatial resolution without sacrificing signal- to-noise ratio. Aim 2 will develop miniaturized stimulation and recording electronics to recover signals tra- ditionally obscured by stimulation artifacts. The recovered data, combined with the ability to simultaneously interact with dozens of skin-surface electrodes, will allow non-invasive mapping, characterization, and con- trol of peripheral nerves. In addition to reducing the complexity, pain, and training required to monitor and manipulate peripheral nerves, this platform will allow for continued innovation in disease diagnostics, sur- face electromyography, neural prosthetics, intraoperative monitoring, and therapeutic stimulation.

项目摘要 拟议的研究结合了新型电子产品和微加工技术，以创建一种非侵入性的， 针对人类周围神经的靶向刺激和表征的研究平台。该阶段II 提案涉及高分辨率周围神经接口的两个重要发展。目标1意志 开发高分辨率和低噪声皮肤表面电极阵列。阵列中的每个电极将 由成本效益的微图案组成，这大大降低了通过疼痛的电极阻抗 少于刺穿皮肤的最上层，从而提供高空间分辨率而不牺牲信号 - 毫无疑问。 AIM 2将产生微型刺激和记录电子设备，以恢复信号传动 被刺激伪影掩盖了。恢复的数据，结合了同时的能力 与数十个皮肤表面电极相互作用，将允许无创映射，表征和构图 周围神经的trol。除了减少监测和训练所需的复杂性，疼痛和训练外 操纵周围神经，该平台将允许在疾病诊断中继续创新 面部肌电图，神经假体，术中监测和治疗性刺激。