Integrative Cancer Nanoscience and Microsystems (IC-NSMS) Training Center

综合癌症纳米科学与微系统（IC-NSMS）培训中心

• 批准号: 8701880
• 负责人: Abhaya Krishna Datye
• 金额: $ 35.18万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8701880
• 关键词: Achievement; Address; Age; Animals; Antineoplastic Agents; Award; Biotechnology; Camping; Cancer Biology; Cancer Center; Cancer Detection; Cancer Research Project; Cells; Cellular biology; Communities; Complex; Core Facility; DNA Sequence Analysis; Detection; Development; Devices; Diagnosis; Disease; Doctor of Philosophy; Drug Delivery Systems; Educational Curriculum; Educational workshop; Electron Microscopy; Employee Strikes; Engineering; Environment; Environmental Exposure; Epidemiologic Studies; Ethics; Faculty; Flow Cytometry; Fluorescence Microscopy; Funding; Generations; Genetic Predisposition to Disease; Genomics; Glues; Goals; Graduate Education; Growth; Image; Immersion Investigative Technique; In Vitro; Interdisciplinary Study; Joints; Laboratories; Malignant Neoplasms; Membrane; Mentors; Microfabrication; Minority; Minority-Serving Institution; Molecular Biology; NCI-Designated Cancer Center; Nanotechnology; New Mexico; Oncologist; Paper; Patients; Positioning Attribute; Postdoctoral Fellow; Prevention; Process; Recruitment Activity; Research; Research Infrastructure; Research Personnel; SEER Program; Schools; Science; Scientist; Series; Structure; Students; Technology; Traineeship; Training; Training Programs; Universities; anticancer research; cancer cell; cancer prevention; cancer therapy; career; chromatin remodeling; drug discovery; graduate student; improved; in vivo; in vivo imaging; instrument; member; microsystems; nano; nanodevice; nanomaterials; nanoprobe; nanoscale; nanoscience; novel; outreach; physical science; population based; programs; public health relevance; symposium; trafficking

DESCRIPTION (provided by applicant): A striking convergence occurred in 2006/07: the UNM Cancer Center (UNMCC) was recognized as one of 60 NCI-designated Cancer Centers in the nation; UNM's application to NSF for an Integrated Graduate Education and Research Traineeship (IGERT) program in Nanoscience and Microsystems (NSMS) was selected by NCI for joint NSF/NCI funding; and the New Mexico legislature approved a new interdisciplinary NSMS PhD degree program at UNM. The resulting integration of nanoscale engineering and physical sciences training into cancer research at UNM generated a series of entirely new interdisciplinary research teams focused on harnessing nanoscale phenomena for understanding, detecting and treating cancer. These include a team that combines novel nanoprobes with in vitro fluorescence and electron microscopy to address altered membrane organization and vesicular trafficking in cancer cells; a team that develops and applies nano- and microdevices for DNA sequencing and analysis of chromatin remodeling in cancer; a team that generates novel probes and instruments for in vivo cancer detection; and a team that focuses on cancer drug discovery and the synthesis of multifunctional nanoprobes for targeted drug delivery. The teams are supported by cutting-edge NCI-supported core facilities in the UNM Cancer Center for in vitro and in vivo imaging, flow cytometry and genomics, and by outstanding NSF- and DoE-supported core facilities in the UNM School of Engineering and in the Los Alamos and Sandia National Laboratories for nanomaterials synthesis, characterization, nano-micro integration and for microfabrication. Fourteen NSMS IGERT graduate students are members of these teams. This application to develop an Integrative Cancer Nanoscience and Microsystems (IC-NSMS) Training Program through the CNTC mechanism builds on the achievements of the NSMS IGERT, including its established research teams and its strong infrastructure for minority recruitment, interdisciplinary mentoring and coursework, ethics training, seminars, symposia and outreach. In the new funding period, we propose to accelerate the recruitment of interdisciplinary graduate students to the NSMS' current cancer-focused teams and to add a postdoc training program; to develop new interdisciplinary teams that will bring even more engineering and physical sciences faculty, graduate students and postdocs into the cancer community; and to specifically enhance the environment for cancer-focused IC-NSMS training via a boot camp to immerse new students in the integration of cancer biology and nanotechnology, an oncologist-led seminar on real-world problems in cancer prevention, detection and treatment and an expanded curriculum on the development of an interdisciplinary cancer-focused career. UNM's nanoscience research originated in the early 80's with the establishment of two strategic research centers, the Center for High Technology Materials and the Center for Microengineered Materials. UNM's materials science research has been recognized by the ISI through the ranking of top 5 universities in impact of materials science papers (1996-2000) and top 10 papers in materials science in citation impact (1991-1995). As a founding member (1972) of the NCI SEER program, UNM's reputation in cancer research was first established though population-based surveillance and epidemiology research, followed since around 1990 by the steady growth of excellent programs in cancer cell and molecular biology research and, since the mid-90s, by increasingly strong contributions of biotechnology to our cancer research programs. The integration of outstanding research communities in cancer and in nanotechnology within a Minority-Serving Institution provides a unique environment for a CNTC focused on applications of nanoscience and microsystems to understand, detect and treat cancer.

描述（由申请人提供）：2006/07年发生惊人的收敛：UNM癌症中心（UNMCC）被认为是全国60个NCI指定的癌症中心之一； NCI为NSF/NSF/NCI资金选择了UNM向NSF的NSF应用于纳米科学和微系统（NSMS）的综合研究生教育和研究培训计划（IGERT）计划；新墨西哥州立法机关批准了UNM的新跨学科NSMS博士学位课程。纳米级工程和物理科学培训的结果整合到UNM生成的一系列全新的跨学科研究团队，着重于利用纳米级现象来理解，检测和治疗癌症。这些团队将新型纳米探针与体外荧光和电子显微镜结合在一起，以解决癌细胞中膜组织和囊泡运输的改变；一支开发和应用纳米和微型电视的团队，用于癌症中染色质重塑的DNA测序和分析；一个为体内癌症检测生成新颖的探针和仪器的团队；以及一个专注于癌症药物发现以及用于靶向药物递送的多功能纳米探针的团队。这些团队得到了UNM癌症中心和体内成像，流式细胞仪和基因组学的最先进的NCI支持的核心设施，以及在UNM工程学院以及INM工程学院以及IN IN IN中获得的杰出NSF和DOE支持的核心设施Los Alamos和Sandia国家实验室用于纳米材料合成，表征，纳米 - 微观整合和微结合。 14名NSMS IGERT研究生是这些团队的成员。 通过CNTC机制开发综合性癌症纳米科学和微型系统（IC-NSMS）培训计划的应用，建立在NSMS IGERT的成就上，包括其既定的研究团队及其对少数群体招聘，跨学科培训，道德培训，道德培训，道德培训的强大基础设施，研讨会，研讨会和宣传。在新的资金期间，我们建议加快跨学科研究生的招聘，加入NSMS目前以癌症为中心的团队，并添加博士后培训计划；为了开发新的跨学科团队，这些团队将把更多的工程和物理科学教师，研究生和博士后带入癌症社区；并通过新兵训练营专门提高以癌症为中心的IC-NSMS培训的环境，以使新学生融入癌症生物学和纳米技术的整合，这是肿瘤学家主导的有关预防癌症预防，检测和治疗和治疗的现实世界中问题的研讨会扩大了有关跨学科癌症职业的发展的课程。 UNM的纳米科学研究起源于80年代初，建立了两个战略研究中心，高科技材料中心和微工程材料中心。 INS的材料科学研究已通过ISI通过在材料科学论文的影响（1996-2000）和引文影响材料科学的十大论文（1991-1995）中获得了ISI的认可。作为NCI SEER计划的创始成员（1972），UNM在癌症研究中的声誉首先建立了基于人群的监视和流行病学研究，随后是自1990年左右以来，癌症细胞和分子生物学研究中优秀计划的稳定增长，以及自90年代中期以来，生物技术对我们的癌症研究计划的贡献越来越强。在少数族裔服务机构中，杰出的癌症和纳米技术研究社区的融合为CNTC提供了一个独特的环境，专注于纳米科学和微系统的应用，以了解，检测和治疗癌症。

项目成果

A unified sensor architecture for isothermal detection of double-stranded DNA, oligonucleotides, and small molecules.

• DOI: 10.1002/cbic.201402615
• 发表时间: 2015-03-23
• 期刊: CHEMBIOCHEM
• 影响因子: 3.2
• 作者: Brown, Carl W., III;Lakin, Matthew R.;Fabry-Wood, Aurora;Horwitz, Eli K.;Baker, Nicholas A.;Stefanovic, Darko;Graves, Steven W.
• 通讯作者: Graves, Steven W.

Synthetic fossilization of soft biological tissues and their shape-preserving transformation into silica or electron-conductive replicas.

• DOI: 10.1038/ncomms6665
• 发表时间: 2014-12-08
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Townson, Jason L.;Lin, Yu-Shen;Chou, Stanley S.;Awad, Yasmine H.;Coker, Eric N.;Brinker, C. Jeffrey;Kaehr, Bryan
• 通讯作者: Kaehr, Bryan

A strand graph semantics for DNA-based computation.

• DOI: 10.1016/j.tcs.2015.07.041
• 发表时间: 2016-06-13
• 期刊: Theoretical computer science
• 影响因子: 1.1
• 作者: Petersen RL;Lakin MR;Phillips A
• 通讯作者: Phillips A

Biophysically inspired rational design of structured chimeric substrates for DNAzyme cascade engineering.

• DOI: 10.1371/journal.pone.0110986
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Lakin MR;Brown CW 3rd;Horwitz EK;Fanning ML;West HE;Stefanovic D;Graves SW
• 通讯作者: Graves SW

Longitudinal Assessment of Lung Cancer Progression in Mice Using the Sodium Iodide Symporter Reporter Gene and SPECT/CT Imaging.

• DOI: 10.1371/journal.pone.0169107
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Price DN;McBride AA;Anton M;Kusewitt DF;Norenberg JP;MacKenzie DA;Thompson TA;Muttil P
• 通讯作者: Muttil P