Integrative Cancer Nanoscience and Microsystems (IC-NSMS) Training Center

综合癌症纳米科学与微系统（IC-NSMS）培训中心

基本信息

批准号：
8324485
负责人：
Abhaya Krishna Datye
金额：
$ 37.08万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8324485
关键词：
Achievement Address Age Animals Antineoplastic Agents Award Biotechnology Camping Cancer Biology Cancer Center Cancer Detection Cancer Research Project Cells Cellular biology Communities Complex Core Facility DNA Sequence Analysis Detection Development Devices Diagnosis Disease Doctor of Philosophy Drug Delivery Systems Educational Curriculum Educational workshop Electron Microscopy Employee Strikes Engineering Environment Environmental Exposure Epidemiologic Studies Ethics Faculty Flow Cytometry Fluorescence Microscopy Funding Generations Genetic Predisposition to Disease Genomics Glues Goals Graduate Education Growth Image Immersion Investigative Technique In Vitro Interdisciplinary Study Joints Laboratories Malignant Neoplasms Membrane Mentors Microfabrication Minority Minority-Serving Institution Molecular Biology NCI-Designated Cancer Center Nanotechnology New Mexico Oncologist Paper Patients Positioning Attribute Postdoctoral Fellow Prevention Process Recruitment Activity Research Research Infrastructure Research Personnel SEER Program Schools Science Scientist Series Structure Students Technology Traineeship Training Training Programs Universities anticancer research cancer cell cancer prevention cancer therapy career chromatin remodeling drug discovery graduate student improved in vivo instrument member microsystems nano nanodevice nanomaterials nanoprobe nanoscale nanoscience novel outreach physical science population based programs public health relevance symposium trafficking

项目摘要

DESCRIPTION (provided by applicant): A striking convergence occurred in 2006/07: the UNM Cancer Center (UNMCC) was recognized as one of 60 NCI-designated Cancer Centers in the nation; UNM's application to NSF for an Integrated Graduate Education and Research Traineeship (IGERT) program in Nanoscience and Microsystems (NSMS) was selected by NCI for joint NSF/NCI funding; and the New Mexico legislature approved a new interdisciplinary NSMS PhD degree program at UNM. The resulting integration of nanoscale engineering and physical sciences training into cancer research at UNM generated a series of entirely new interdisciplinary research teams focused on harnessing nanoscale phenomena for understanding, detecting and treating cancer. These include a team that combines novel nanoprobes with in vitro fluorescence and electron microscopy to address altered membrane organization and vesicular trafficking in cancer cells; a team that develops and applies nano- and microdevices for DNA sequencing and analysis of chromatin remodeling in cancer; a team that generates novel probes and instruments for in vivo cancer detection; and a team that focuses on cancer drug discovery and the synthesis of multifunctional nanoprobes for targeted drug delivery. The teams are supported by cutting-edge NCI-supported core facilities in the UNM Cancer Center for in vitro and in vivo imaging, flow cytometry and genomics, and by outstanding NSF- and DoE-supported core facilities in the UNM School of Engineering and in the Los Alamos and Sandia National Laboratories for nanomaterials synthesis, characterization, nano-micro integration and for microfabrication. Fourteen NSMS IGERT graduate students are members of these teams. This application to develop an Integrative Cancer Nanoscience and Microsystems (IC-NSMS) Training Program through the CNTC mechanism builds on the achievements of the NSMS IGERT, including its established research teams and its strong infrastructure for minority recruitment, interdisciplinary mentoring and coursework, ethics training, seminars, symposia and outreach. In the new funding period, we propose to accelerate the recruitment of interdisciplinary graduate students to the NSMS' current cancer-focused teams and to add a postdoc training program; to develop new interdisciplinary teams that will bring even more engineering and physical sciences faculty, graduate students and postdocs into the cancer community; and to specifically enhance the environment for cancer-focused IC-NSMS training via a boot camp to immerse new students in the integration of cancer biology and nanotechnology, an oncologist-led seminar on real-world problems in cancer prevention, detection and treatment and an expanded curriculum on the development of an interdisciplinary cancer-focused career. UNM's nanoscience research originated in the early 80's with the establishment of two strategic research centers, the Center for High Technology Materials and the Center for Microengineered Materials. UNM's materials science research has been recognized by the ISI through the ranking of top 5 universities in impact of materials science papers (1996-2000) and top 10 papers in materials science in citation impact (1991-1995). As a founding member (1972) of the NCI SEER program, UNM's reputation in cancer research was first established though population-based surveillance and epidemiology research, followed since around 1990 by the steady growth of excellent programs in cancer cell and molecular biology research and, since the mid-90s, by increasingly strong contributions of biotechnology to our cancer research programs. The integration of outstanding research communities in cancer and in nanotechnology within a Minority-Serving Institution provides a unique environment for a CNTC focused on applications of nanoscience and microsystems to understand, detect and treat cancer. PUBLIC HEALTH RELEVANCE: While nanoscience research was growing steadily at UNM in the 90s, there were relatively few applications of nanoscience to cancer biology in New Mexico until our NSF IGERT in Nanoscience and Microsystems (2006- 2010) was selected for co-funding by NCI. The award jump-started a process of integration between physical scientists, cancer scientists and engineers in which talented graduate students provided the glue that nucleated new research teams and drove their development. Members of the interdisciplinary NSMS graduate program have established a strong track record for the cross training of talented students in nanoscience, microsystems and cancer biology and are well placed to continue and enhance this cross training through the NCI CNTC mechanism. Through immersion in highly multidisciplinary research teams the program will help to build the nation's cancer nanoscience workforce and will advance the understanding, detection and treatment of cancer.

描述（由申请人提供）： 2006/2007 年出现了惊人的趋同：新墨西哥大学癌症中心 (UNMCC) 被认定为全国 60 个 NCI 指定癌症中心之一；新墨西哥大学向 NSF 申请纳米科学和微系统 (NSMS) 综合研究生教育和研究培训 (IGERT) 计划，并被 NCI 选择获得 NSF/NCI 联合资助；新墨西哥州立法机构批准了新墨西哥大学新的跨学科 NSMS 博士学位课程。由此，新墨西哥大学将纳米工程和物理科学培训整合到癌症研究中，产生了一系列全新的跨学科研究团队，专注于利用纳米现象来理解、检测和治疗癌症。其中包括一个将新型纳米探针与体外荧光和电子显微镜相结合的团队，以解决癌细胞膜组织和囊泡运输的改变；一个开发和应用纳米和微型设备进行 DNA 测序和癌症染色质重塑分析的团队；一个开发用于体内癌症检测的新型探针和仪器的团队；以及一个专注于癌症药物发现和用于靶向药物输送的多功能纳米探针合成的团队。这些团队得到了新墨西哥大学癌症中心先进的 NCI 支持的体外和体内成像、流式细胞术和基因组学核心设施的支持，以及新墨西哥大学工程学院和美国国家科学基金会 (NSF) 和美国能源部 (DoE) 支持的杰出核心设施的支持。洛斯阿拉莫斯和桑迪亚国家实验室致力于纳米材料合成、表征、纳米-微集成和微加工。 14 名 NSMS IGERT 研究生是这些团队的成员。这项通过 CNTC 机制开发综合癌症纳米科学和微系统 (IC-NSMS) 培训计划的申请建立在 NSMS IGERT 的成就之上，包括其已建立的研究团队及其强大的少数群体招募、跨学科指导和课程作业、伦理培训基础设施、研讨会、专题讨论会和外展活动。在新的资助期内，我们建议加快NSMS现有癌症研究团队的跨学科研究生招募，并增加博士后培训项目；建立新的跨学科团队，将更多的工程和物理科学教师、研究生和博士后带入癌症界；并通过新兵训练营专门改善以癌症为中心的 IC-NSMS 培训环境，让新生沉浸在癌症生物学和纳米技术的整合中，由肿瘤学家主导的关于癌症预防、检测和治疗中现实世界问题的研讨会以及扩展了以癌症为中心的跨学科职业发展的课程。新墨西哥大学的纳米科学研究起源于20世纪80年代初，当时建立了两个战略研究中心：高技术材料中心和微工程材料中心。新墨西哥大学的材料科学研究得到了 ISI 的认可，通过材料科学论文影响力前 5 名大学（1996-2000 年）和材料科学论文引文影响力前 10 名大学（1991-1995 年）的排名。作为 NCI SEER 项目的创始成员（1972 年），新墨西哥大学在癌症研究方面的声誉首先通过基于人群的监测和流行病学研究而建立，随后自 1990 年左右开始，癌细胞和分子生物学研究方面的优秀项目稳步增长，自 90 年代中期以来，生物技术对我们的癌症研究计划的贡献日益强大。将癌症和纳米技术方面的杰出研究团体整合到少数族裔服务机构内，为专注于应用纳米科学和微系统来理解、检测和治疗癌症的 CNTC 提供了独特的环境。公共健康相关性：虽然新墨西哥大学的纳米科学研究在 90 年代稳步增长，但在新墨西哥州，纳米科学在癌症生物学中的应用相对较少，直到我们的 NSF IGERT 纳米科学和微系统（2006-2010 年）被 NCI 选择共同资助。该奖项启动了物理科学家、癌症科学家和工程师之间的整合过程，在这个过程中，才华横溢的研究生提供了凝聚新研究团队并推动其发展的粘合剂。跨学科 NSMS 研究生项目的成员在纳米科学、微系统和癌症生物学领域的优秀学生交叉培训方面建立了良好的记录，并且有能力通过 NCI CNTC 机制继续和加强这种交叉培训。通过高度多学科的研究团队的投入，该项目将有助于建立国家的癌症纳米科学队伍，并将促进对癌症的理解、检测和治疗。