Developmental Brain Atlas Tools and Data Applied to Humans and Macaques

应用于人类和猕猴的发育脑图谱工具和数据

基本信息

批准号：
8644910
负责人：
Marc Niethammer
金额：
$ 35.34万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-08 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8644910
关键词：
3 year old Accounting Address Adolescent Age Animal Model Animals Appearance Atlases Autistic Disorder Behavioral Birth Brain Characteristics Childhood Cognitive Communities Comparative Study Complex Confidence Intervals Cross-Sectional Studies Data Databases Development Diffusion Diffusion Magnetic Resonance Imaging Disease Documentation Evaluation Female Fiber Gender Generations Grant Histocompatibility Testing Human Human Development Image Imaging Device Infant Infection Instruction Internet Lead Life Lobar Longitudinal Studies Macaca Macaca mulatta Magnetic Resonance Imaging Measurement Measures Mental disorders Methodology Methods Modeling Monkeys National Institute of Mental Health Nature Neurodevelopmental Disorder Organism Pathology Pattern Pharmaceutical Preparations Population Positioning Attribute Prevalence Primates Procedures Process Property Published Comment Reporting Research Research Personnel Resources Sampling Schizophrenia Sex Characteristics Slice Social Interaction Source Source Code Staging Statistical Methods Statistical Models Statistical sensitivity Structure Techniques Testing Thick Time Tissues United States National Institutes of Health Variant Weight base brain tissue cognitive function cohort comparative computational atlas computerized tools cost effective data acquisition design early adolescence experience human data infancy innovation insight longitudinal database male method development morphometry neonate neurodevelopment neuroimaging neuropathology nonhuman primate novel operation prenatal public health relevance relating to nervous system sex tool tool development white matter

项目摘要

DESCRIPTION (provided by applicant): In the last decade, MRI studies of human brain morphometry have been used to investigate a multitude of pathologies and drug-related effects in psychiatric research. Better understanding of normal neural development is essential to gain a better understanding of the underlying pathology of neurodevelopmental disorders such as autism or schizophrenia, as the timing of an insult into the developing brain is often critical in defining the resulting disorder. Nonhuman primates, and in particular macaque monkeys, have been widely used in animal models to investigate the neural substrates of human development in higher cognitive functions and complex social interactions. However, we lack crucial, detailed information of normal brain maturation in macaques, especially in the rapidly changing early stages. Matching maturational periods in humans with those in macaques aids us in establishing nonhuman primate translational models of developmental neuropathology. This project will provide three results: a) a developmental macaque brain MR database, b) the corresponding computational toolbox for cross-sectional and longitudinal atlas building and c) a comparative study contrasting human and macaque brain development and maturation patterns in both genders based on the former. The computational atlas building toolbox will be of translational nature as it is applied to the existing human NIH MRI database of normal brain development, as well as the proposed macaque brain development database. This longitudinal database will be acquired from a cohort of healthy macaque monkeys ranging from a few week olds up to 3-year-old adolescents. This grant is thus translational from a viewpoint of both the study of brain development as well as method and tool development. This creates an immensely valuable resource for primate researcher, as well as for the general neuroimaging field. The comparative study will allow us to characterize normal brain development in the rhesus macaque and compare it to human brain development. We expect that the efficient and cost-effective creation and dissemination of this unique database, the computational toolbox, along with the results from the developmental study will lead to the creation of many new translational primate models of developmental neuropathology worldwide.

描述（由申请人提供）：在过去的十年中，对人脑形态计量学的MRI研究已用于研究精神研究中的多种病理和与药物有关的作用。更好地了解正常神经发育对于更好地理解自闭症或精神分裂症等神经发育障碍的潜在病理至关重要，因为侮辱大脑的时间通常对于定义结果疾病通常至关重要。非人类灵长类动物，尤其是猕猴，已被广泛用于动物模型中，以研究人类发展的神经底物在较高的认知功能和复杂的社会相互作用中。但是，我们缺乏猕猴正常大脑成熟的至关重要的详细信息，尤其是在快速变化的早期阶段。将人类的成熟时期与猕猴中的成熟时期相匹配，这有助于我们建立发育神经病理学的非人类灵长类动物翻译模型。该项目将提供三个结果：a）一个发育猕猴的大脑MR数据库，b）横截面和纵向地图集的相应计算工具箱以及c）比较研究，将两种基于前者的性别的人和猕猴的脑发育和成熟模式进行了对比。计算地图集构建工具箱将具有转化性质，因为它应用于正常大脑发育的现有人NIH MRI数据库以及拟议的猕猴脑发育数据库。该纵向数据库将从一群健康的猕猴队中获取，范围从几个星期至3岁的青少年不等。因此，从研究大脑发育以及方法和工具开发的研究的角度来看，这笔赠款是翻译的。这为灵长类动物的研究人员以及一般的神经影像领域创造了非常宝贵的资源。比较研究将使我们能够表征恒河猴中正常的大脑发育，并将其与人脑发育进行比较。我们预计，这个独特的数据库（计算工具箱）的有效且具有成本效益的创建以及发展研究的结果将导致创建许多全球发育神经病理学的新变化灵长类动物模型。