Burden, Depression, and Health in Dementia Caregivers: The Role of Emotion

痴呆症护理人员的负担、抑郁和健康：情绪的作用

• 批准号: 8788220
• 负责人: Robert Wayne Levenson
• 金额: $ 5.64万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8788220
• 关键词: Address; Affect; Affective; Age; Aging; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; California; Caregiver Burden; Caregivers; Caring; Cessation of life; Characteristics; Cognitive; Couples; Data; Dementia; Diagnosis; Discipline of Nursing; Disease; Economics; Educational Intervention; Emotional; Emotions; Empathy; Family; Frontotemporal Dementia; Genetic; Genetic screening method; Health; Impairment; Intervention; Language; Lead; Life; Life Expectancy; Link; Measures; Memory; Mental Depression; Mental Health; Methodology; Modeling; Motor; Neurodegenerative Disorders; Neurologic; Neurology; Outcome; Participant; Patients; Pattern; Personal Satisfaction; Personality; Population; Prevalence; Program Research Project Grants; Progressive Disease; Psychology; Public Health; Recruitment Activity; Research; Risk; Role; Sampling; San Francisco; Science; Social Functioning; Spouse Caregiver; Spouses; Symptoms; Synapses; Testing; Universities; Work; age related; caregiver education; caregiving; clinical care; cognitive function; efficacy testing; emotion regulation; emotional stimulus; improved; innovation; interdisciplinary approach; loved ones; multidisciplinary; neural circuit; neuron loss; neuropsychological; novel; physical conditioning; programs; psychologic; response; sex; therapy design

DESCRIPTION (provided by applicant): Caring for a loved one with a neurodegenerative disease can be a meaningful part of family life. However, it can also be associated with negative outcomes for caregivers, including increased burden and reduced health and well-being. For the past 10 years, our multidisciplinary group (neurology, nursing, and psychology) has collaborated on a program project grant (AG19724) focusing on patients with frontotemporal dementia (FTD). FTD typically presents with impairments in emotional and social functioning, with many aspects of cognitive functioning initially spared. Although this constellation of symptoms can be extremely difficult for caregivers, there has been relatively little research focusing on FTD caregiving or comparing FTD caregivers with other kinds of caregiving. We propose to study the associations between patient and caregiver emotional functioning and negative caregiver outcomes (i.e., higher burden, lower health and well-being). We will recruit 200 patients with FTD, Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) and their caregiver spouses plus 50 neurologically normal controls and their spouses (Total N = 500). Emotional functioning will be evaluated in all participants using an observational approach that assesses emotional functioning in three domains: (a) emotional reactivity (responding to emotional stimuli), (b) emotion regulation (adjusting emotional responses to situational demands), and (c) emotional empathy (recognizing others' emotions, responding emotionally to others' emotions, helping others in need). Caregiver outcomes will be assessed using well- established measures of caregiver burden, mental and physical health, and well-being. The research addresses four specific aims: Aim 1: To determine how specific emotional deficits in patients contribute to negative caregiver outcomes (i.e., higher caregiver burden, lower caregiver health and well-being). Aim 2: To understand how caregivers' emotional functioning and select genetic and personality characteristics predict vulnerability to the negative effects of caregiving. Aim 3: To characterize the emotional qualities of caregiver- patient interactions in FTD, AD, and ALS. Aim 4: To test the efficacy of a caregiver training intervention designed to improve ability to recognize emotion in reducing negative caregiver outcomes. The proposed research is innovative in its multidisciplinary approach, translational application of basic affective science methodology to the study of dementia caregiving, focus on FTD caregiving, emphasis on emotional functioning in both patients and caregivers, and testing of an intervention for caregivers that might reduce negative caregiver outcomes and improve the caregiver-patient relationship.

描述（由申请人提供）：照顾一个神经退行性疾病的亲人可能是家庭生活中有意义的一部分。但是，它也可能与护理人员的负面结果有关，包括增加负担以及减少健康和福祉。在过去的10年中，我们的多学科小组（神经病学，护理和心理学）一直在计划项目赠款（AG19724）合作，重点是额叶痴呆症患者（FTD）。 FTD通常表现出情感和社会功能的损害，而认知功能的许多方面最初都幸免。尽管对于护理人员而言，这一症状存在可能非常困难，但关注FTD护理或将FTD护理人员与其他类型的护理人员进行比较的研究相对较少。我们建议研究患者与照料者的情绪功能与负面照顾者结果之间的关联（即，负担更大，健康和福祉）。我们将招募200例FTD，阿尔茨海默氏病（AD）和肌萎缩性侧索硬化症（ALS）及其护理人员配偶以及50个神经学正常对照及其配偶（总n = 500）。情绪功能将在所有参与者中使用观察方法在三个领域中评估情绪功能进行评估：（a）情绪反应性（对情绪刺激做出反应），（b）情绪调节（调整情绪对情境需求的情绪反应），以及（c）情绪同情心（识别其他人的情绪，对其他人的情绪响应，对其他人的情绪响应，对其他人的情绪产生反应），对其他需要的情感，对其他需要，对其他需要，对其他人的需求）。护理人员的成果将通过确定的护理人员负担，精神和身体健康以及福祉的衡量标准进行评估。该研究针对四个具体目标：目标1：确定患者的特定情绪缺陷如何促进负面照顾者的结果（即，更高的护理人员负担，较低的照料者健康和福祉）。目标2：了解护理人员的情绪功能如何并选择遗传和人格特征可以预测对护理的负面影响的脆弱性。目标3：表征FTD，AD和ALS中护理人员患者相互作用的情感品质。目标4：测试护理人员培训干预措施的功效，旨在提高识别情绪减少负面护理人结果的能力。拟议的研究在其多学科方法，基本情感科学方法论的翻译应用中具有创新性，对痴呆症护理的研究，专注于FTD护理，强调患者和看护者的情绪功能，以及对护理人员进行干预措施的测试，这些干预者可能会减少负面照顾者的护理和改善Caregiver Caregiver Caregiver Caregiver-Patient-Patient-Patient-Patient-Patient-Patient-Patient-Patient-Patient-Patient-Patient-Patient。