Dynamic Interplay of Socioeconomic Position, Perinatal Outcomes and Cardiovascula

社会经济地位、围产期结局和心血管的动态相互作用

• 批准号: 8077799
• 负责人: Debbie S Barrington
• 金额: $ 20.83万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-18 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8077799
• 关键词: Address; Adolescence; Adult; African American; Area; Birth; Birth Weight; Blood Pressure; Body mass index; Cardiovascular Diseases; Cardiovascular system; Categories; Data; Data Analyses; Development; Development Plans; Disadvantaged; Disease Outcome; Elderly; Epidemiology; Focus Groups; Funding; Gender; Goals; Health; Health Status; Injury; Institution; Intervention; Knowledge; Link; Longevity; Mediating; Mentors; Methodology; Modeling; Outcome; Perinatal; Pilot Projects; Probability; Publications; Race; Recruitment Activity; Reproductive Health; Research; Research Personnel; Resources; Risk; Role; Smoking Behavior; Socioeconomic Factors; Socioeconomic Status; Stress; Students; Training; Ursidae Family; Variant; Weight; Woman; Work; alcohol behavior; base; cardiovascular disorder risk; career; career development; critical period; experience; health disparity; intergenerational; low socioeconomic status; meetings; middle age; next generation; offspring; perinatal health; public health relevance; racial and ethnic disparities; reproductive; reproductive epidemiology; social; socioeconomics; stressor; symposium; working group; young adult

DESCRIPTION (provided by applicant): The following proposal is from a candidate with past and current research that has focused on (1) the effect of intergenerational socioeconomic factors on the racial/ethnic disparities in perinatal and cardiovascular outcomes, and (2) the study of nativity status (foreign-born vs. US-born) variations in African-American health. The mentoring, training, educational and research experiences described in this proposal have been specifically tailored to meet the candidate's career goals to (1) create and uphold a distinguished publication record that produces relevant, multi-level, and methodologically rigorous work for contributing to the national goal of eliminating racial/ethnic disparities in health, (2) become an independent, externally-funded researcher in the lifecourse and social epidemiology of African-American health, and in the racial/ethnic disparities in reproductive and cardiovascular health, specifically, and (3) educate and inspire the next generation of students and researchers to eliminate racial/ethnic disparities in health. A career development plan has been constructed for training the candidate in advanced longitudinal data methodology via coursework. Through extensive mentoring by experts in the fields of social and reproductive epidemiology, the candidate will gain knowledge in the substantive areas of social and reproductive epidemiology and knowledge in the stress mechanisms mediating the association between socioeconomic position (SEP) and women's reproductive and cardiovascular health. Participation in collaborative activities, such as working groups, seminars and conferences internally and external to the candidate's institution are planned for enhancement of professional development. The proposed research includes (1) longitudinal data analysis examining the interaction of socioeconomic trajectories and health trajectories over the lifecourse among 400 African American and white women in the Emerging Health Disparities (DISPAR) Study and (2) the conduct of a qualitative pilot study examining the role of stress mechanisms in the effects of SEP trajectories on the reproductive and cardiovascular health of 160 African American Women. Consideration of cumulative risks and the interactions of SEP, perinatal outcomes, reproductive health and cardiovascular outcomes across the lifecourse may reveal optimal windows for intervention to enhance the health of African American women who disproportionately bear the burden of poor reproductive and CVD outcomes. PUBLIC HEALTH RELEVANCE: African American women have excess burden of poor reproductive health outcomes and cardiovascular disease in comparison to white women. Recent studies show a link between maternal birth weight, offspring's birth weight and cardiovascular disease (CVD). Socioeconomic position (SEP) from birth through adolescence, young adulthood and middle adulthood may be contributing to and interacting with health across the lifecourse to produce racial disparities in reproductive and cardiovascular health outcomes. The proposed study seeks to document this dynamic interplay of SEP, birth weight and cardiovascular health over the lifecourse, uncover the stress mechanisms through which SEP over the lifecourse influence health and well being, and reveal the different strategies African American women employ to mitigate their health injury.

描述（由申请人提供）：以下提案来自具有过去和当前研究的候选人，其重点是（1）围产期和心血管造成成果中的代际社会经济因素对种族/族裔差异的影响，以及（2）研究耶稣降生（2）对非洲人对非洲人的差异的研究。 The mentoring, training, educational and research experiences described in this proposal have been specifically tailored to meet the candidate's career goals to (1) create and uphold a distinguished publication record that produces relevant, multi-level, and methodologically rigorous work for contributing to the national goal of eliminating racial/ethnic disparities in health, (2) become an independent, externally-funded researcher in the lifecourse and social epidemiology of非洲裔美国人的健康，以及在生殖和心血管健康方面的种族/族裔差异，特别是（3）教育和启发下一代学生和研究人员消除健康中的种族/种族差异。 已经建立了一项职业发展计划，用于通过课程培训高级纵向数据方法的候选人。 通过社会和生殖流行病学领域的专家的广泛指导，候选人将在社会和生殖流行病学和知识的实质领域中获得知识，并在介导社会经济地位（SEP）与妇女生殖和心血管健康之间的关联的压力机制中获得知识。 计划参加候选人机构的内部和外部的协作活动，例如工作组，研讨会和会议，以增强专业发展。 拟议的研究包括（1）纵向数据分析，研究了400名非裔美国人和白人妇女在新兴健康差异（DISPAR）研究中的社会经济轨迹和健康轨迹的相互作用，以及（2）进行定性试验性研究的进行，该研究检查了SEP女性对SEP妇女在SEP妇女对生殖的影响的作用。 考虑累积风险以及SEP，围产期结局，生殖健康和心血管结局的相互作用，可能会揭示出最佳的干预窗口，以增强非裔美国妇女的健康，而非洲裔美国妇女的健康状况不成比例，这些妇女承担了良好的生殖和CVD效果不佳。 公共卫生相关性：与白人妇女相比，非洲裔美国妇女的生殖健康成果和心血管疾病的负担不佳。 最近的研究表明，母体出生体重，后代的出生体重与心血管疾病（CVD）之间的联系。 从出生到青春期，成年和成年中期的社会经济地位（SEP）可能会导致整个生命的健康和与健康相互作用，从而在生殖和心血管健康结果中产生种族差异。 拟议的研究旨在记录SEP，出生体重和心血管健康的这种动态相互作用，并揭示了Sep跨越生命的压力机制影响健康和福祉，并揭示了非洲裔美国妇女使用的不同策略来减轻其健康损伤。