Animal Phenotyping Core

动物表型核心

• 批准号: 8688230
• 负责人: Martin Myers
• 金额: $ 5.75万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8688230
• 关键词: Animal Model; Animals; Body Composition; Cannulations; Cardiovascular system; Catheterization; Consultations; Development; Diagnostic; Diet; Disease; Education; Equipment; Ethers; Euglycemic Clamping; Event; Exercise; Genetic; Glucose Clamp; Goals; Individual; Intervention; Metabolic; Metabolic Diseases; Metabolism; Michigan; Molecular Genetics; Mus; Nutrient; Obesity; Obesity associated disease; Pharmaceutical Preparations; Phenotype; Prevention strategy; Process; Public Health; Rattus; Research; Research Personnel; Rodent; Rodent Model; Services; System; Techniques; Technology; Telemetry; Tissue Harvesting; combat; cost effective; design; food consumption; improved; insight; mouse model; new technology; novel; nutrition; respiratory; response; tool; treatment strategy

Animal Phenotyping Core A thereugh understanding ef the precesses centrelling the response te nutrients and ef the mechanisms that centribute te obesity and related metabolic diseases is required if we are te effectively combat these condifions. The detailed analysis of animals with altered metabolism (e.g. due te dietary, molecular, genefic, or pharmacological manipulation) at a level that reveals basic underiying mechanisms of control requires specialized expertise and technology not normally available to individual investigators. Established in 2006, the goals efthe MNORC Animal Phenotyping Cere was are te provide state-of-the art equipment, services and censultafive advice regarding the detailed metabolic phenotyping of rodent models of metabolic diseases. The Animal Phenotyping Core makes the metabolic analysis of rodent models of disease available, expedifious, affordable, effective, and convenient for individual investigators. In addition to providing educafion, consultation and advice regarding the analysis ef rat and mouse models with altered metabolism, the Core provides phenotyping services on specialized equipment that it operates. Specifically, the cere determines body eempesitien and utilizes the CLAMS apparatus and other systems to examine metabolic rate, respiratory quotient, food consumption, and acfivity in rodent models ef metabolic disease. The Cere also examines the response te exercise and examines cardiovascular and ether parameters by telemetry in rodents. The Core performs hyperinsulinemic/euglycemic clamp studies including specialized analysis ef metabolite storage and release in rats and mice, as well as providing catheterizafion/cannulafien services and fissue harvesting in rodents. Thus, overall, the Animal Phenotyping Core will consultatively aid individual investigators in designing an appropriate experimental plan for the metabolic analysis of animal models relevant to obesity and then provide the tools and services necessary to effect this analysis. This research is relevant to public health because it will increase our understanding ef the events that underiie the development ef obesity and its complications, and hence will facilitate the develepment ef improved diagnostic, prevenfion and treatment strategies.

动物表型核心 a在那里，理解的进度集中了养分的反应，并在有效地应对这些条件时需要将肥胖和相关代谢性疾病中心的机制和相关的代谢疾病。对新陈代谢改变的动物（例如，饮食，分子，基因科或药理学操纵）的详细分析，该水平揭示了基本的控制机制基本的控制机制需要专业的专业知识和技术通常不可用的人。成立于2006年的MNORC动物表型的目标是提供有关代谢性疾病啮齿动物模型的详细代谢表型的最先进的设备，服务和人口普及的建议。动物表型核心使对个别研究人员的啮齿动物模型进行代谢分析，快速，负担得起，有效且方便。除了提供有关分析EF RAT和鼠标模型的教育，咨询和建议的建议外，该核心还为其运营的专用设备提供了表型服务。具体而言，CERE决定了身体的eempesitien，并利用蛤s仪和其他系统来检查啮齿动物模型的代谢率，呼吸商，食物消耗和助剂EF代谢疾病。 该室还检查了练习的反应，并检查了啮齿动物中遥测的心血管和醚参数。该核心进行高胰岛素/尤格血糖夹具研究，包括专门的分析EF代谢产物储存和大鼠和小鼠的释放，以及提供导管/囊藻/囊菌服务和啮齿动物的Fissue收获。因此，总体而言，动物表型核心将协商个人研究人员设计适当的实验计划，以对与肥胖相关的动物模型的代谢分析，然后提供对该分析进行必要的工具和服务。这项研究与公共卫生有关，因为它将提高我们的理解，这些事件涉及肥胖的发展及其并发症，因此将有助于改善诊断，预防效果和治疗策略。