MIDWEST PROGENITOR CELL CONSORTIUM

中西部祖细胞联盟

• 批准号: 8358235
• 负责人: James Alexander Thomson
• 金额: $ 31.28万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358235
• 关键词: Cardiac; Cells; Cellular biology; Collaborations; Funding; Genetic Programming; Goals; Grant; Hematopoietic stem cells; Human; Minnesota; National Center for Research Resources; Pluripotent Stem Cells; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Somatic Cell; Source; Stem cells; United States National Institutes of Health; Universities; Wisconsin; cost; progenitor; programs; self-renewal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells. The Midwest Progenitor Cell Consortium is a collaboration between the UW-Madison and the University of Minnesota, which will serve as a research hub within the NHLBI's Progenitor Cell Biology Consortium. The goal is to develop new strategies to convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells through identification of genetic program leading to formation of pre-HSCs and cardiac progenitors and activation of self-renewal program in lineage restricted cells. This project uses WNPRC Stem Cell Resources.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 目的：将人多能干细胞和体细胞转化为造血干细胞（HSC）和自我更新的心脏祖细胞。 中西部祖细胞联盟是威斯康星大学麦迪逊分校和明尼苏达大学之间的合作项目，该联盟将作为 NHLBI 祖细胞生物学联盟内的研究中心。目标是开发新策略，通过鉴定导致前 HSC 和心脏祖细胞形成的遗传程序以及激活自我更新程序，将人类多能干细胞和体细胞转化为造血干细胞 (HSC) 和自我更新心脏祖细胞在谱系限制细胞中。 该项目使用 WNPRC 干细胞资源。