MIDWEST PROGENITOR CELL CONSORTIUM

中西部祖细胞联盟

• 批准号: 8173156
• 负责人: James Alexander Thomson
• 金额: $ 4.13万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173156
• 关键词: Cardiac; Cells; Cellular biology; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Funding; Genetic Programming; Goals; Grant; Hematopoietic stem cells; Human; Institution; Minnesota; Research; Research Personnel; Resources; Somatic Cell; Source; Stem cells; United States National Institutes of Health; Universities; progenitor; programs; self-renewal; stem

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells. The Midwest Progenitor Cell Consortium is a collaboration between the UW-Madison and the University of Minnesota, which will serve as a research hub within the NHLBI's Progenitor Cell Biology Consortium. The goal is to develop new strategies to convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells through identification of genetic program leading to formation of pre-HSCs and cardiac progenitors and activation of self-renewal program in lineage restricted cells. Dr. Slukvin's involvement in the consortium relies on WNPRC Stem Cell Resources.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：将人多能干细胞和体细胞转化为造血干细胞（HSC）和自我更新的心脏祖细胞。 中西部祖细胞联盟是威斯康星大学麦迪逊分校和明尼苏达大学之间的合作项目，该联盟将作为 NHLBI 祖细胞生物学联盟内的研究中心。目标是开发新策略，通过鉴定导致前 HSC 和心脏祖细胞形成的遗传程序以及激活自我更新程序，将人类多能干细胞和体细胞转化为造血干细胞 (HSC) 和自我更新心脏祖细胞在谱系限制细胞中。 Slukvin 博士参与该联盟依赖于 WNPRC 干细胞资源。