CONTRACEPTION BY BLOCKADE OF PERIOVULATORY EVENTS IN PRIMATES (U54 CENTER)

通过阻断灵长类动物排卵期事件来避孕（U54 中​​心）

• 批准号: 8357876
• 负责人: RICHARD L STOUFFER
• 金额: $ 5.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357876
• 关键词: Address; Adult; Animals; Cells; Cervical; Contraceptive Agents; Contraceptive methods; Development; Drug Industry; Estrogens; Event; Female; Fertility; Fertilization; Funding; Grant; Individual; Macaca; Menstrual cycle; Modality; Monkeys; National Center for Research Resources; Nuclear; Oocytes; Ovary; Ovulation; Pharmaceutical Preparations; Primates; Principal Investigator; Progress Reports; Proteins; Publications; Research; Research Infrastructure; Research Project Grants; Resources; Rupture; Selective Estrogen Receptor Modulators; Source; Testing; Translational Research; United States National Institutes of Health; Woman; base; contraceptive efficacy; cost; egg; gamete transport; nonhuman primate; novel; oocyte maturation; prevent; reproductive; research and development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Development Research Center that targets the discovery and development of novel contraceptive drugs that prevent one or more periovulatory events in adult, female primates during the menstrual cycle. Three research projects and one animal core utilize Old World (macaque) monkeys to generate new information and proof-of-concept regarding modalities that prevent oocyte fertilization, and hence fertility, in women. Project I, "Control of Oocyte Maturation", will address the hypothesis that novel follicle cell-, and oocyte-derived proteins control nuclear and cytoplasmic maturation of the oocyte, and can be exploited to disrupt timely egg maturation. Also this project will analyze follicle/cumulus- and oocyte-derived proteins that control cumulus-oocyte expansion and follicle rupture, and test whether antagonists prevent ovulation and egg release. Project III, "Control of Gamete Transport and Fertilization" tests the hypothesis that estrogen action is essential for normal oviductal and cervical function, such that a selective estrogen receptor modulator (SERM) will disrupt gamete transport, and hence, fertilization. Promising agents discovered in Projects I - III will be tested in the Nonhuman Primate Contraceptive Core for contraceptive efficacy and reversibility. Existing ties with the pharmaceutical industry and OB/GYN, OHSU, will promote translational research relevant to formulating novel ovary/reproductive tract-based contraceptives for women. See individual projects for progress reports and publications.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 发展研究中心的目标是发现和开发新型避孕药，以预防成年雌性灵长类动物在月经周期期间发生一种或多种排卵期事件。 三个研究项目和一个动物核心利用旧世界（猕猴）猴子来生成有关阻止卵母细胞受精从而阻止女性生育的方式的新信息和概念验证。 项目 I“卵母细胞成熟的控制”将提出这样的假设：新型卵泡细胞和卵母细胞衍生的蛋白质控制卵母细胞的核和细胞质成熟，并可用于破坏卵子的及时成熟。 该项目还将分析控制卵丘-卵母细胞扩张和卵泡破裂的卵泡/卵丘和卵母细胞衍生的蛋白质，并测试拮抗剂是否阻止排卵和卵子释放。 项目 III“配子运输和受精的控制”测试了这样的假设：雌激素的作用对于正常的输卵管和宫颈功能至关重要，因此选择性雌激素受体调节剂（SERM）会扰乱配子运输，从而扰乱受精。 项目 I - III 中发现的有前景的药物将在非人类灵长类动物避孕核心中进行避孕功效和可逆性测试。 与制药行业和 OB/GYN、OHSU 的现有联系将促进与为女性制定新型卵巢/生殖道避孕药相关的转化研究。请参阅各个项目的进度报告和出版物。