Improved Models to Inform Tobacco Product Regulation

改进模型以告知烟草产品监管

• 批准号: 8737818
• 负责人: STANTON ARNOLD GLANTZ
• 金额: $ 399.98万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8737818
• 关键词: Accounting; Acute; Behavioral; Behavioral Model; Biological Markers; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular system; Decision Making; Development; Disease; Disease model; Economic Models; Education; Environmental Tobacco Smoke; Functional disorder; Future; Health Care Costs; Informatics; Long-Term Effects; Lung; Lung diseases; Marketing; Modeling; Process; Regulation; Research; Risk; Science; Services; Testing; Tobacco; Tobacco Control Research; Tobacco use; Training Programs; economic impact; improved; post-doctoral training; public education; response; risk perception; social; tobacco advertising

DESCRIPTION (provided by applicant): The overarching theme of this Tobacco Center of Regulatory Science is the development of improved models to inform tobacco product regulatory strategies that integrate 1) economic impacts of tobacco use on health costs, 2) risk perceptions, perceived acceptability, consumer responses to pro-tobacco marketing and anti-tobacco messages and other social determinants of tobacco use, and 3) rapid changes in risk due to tobacco use and secondhand smoke exposure as manifested in cardiovascular and pulmonary dysfunction. This TCORS includes five full projects (one on economic models, two on behavioral models, and two on cardiovascular and pulmonary disease models), two developmental projects (one on behavioral models and one on cardiovascular and pulmonary disease models), three Cores (Administrative, Informatics and Analysis, and Biomarker), a postdoctoral training program and a process for selecting future developmental projects. The results will inform FDA regulation of the manufacture, distribution and marketing of tobacco products by providing an improved scientific framework in which to evaluate the likely effects of specific regulatory strategies by developing 1) improved economic models for analysis of proposed regulations that account for short-term as well as long-term effects of tobacco use, 2) better understanding of behavioral and social determinants of tobacco use (including perception of risk and decision making processes) to inform the economic models, regulation of marketing, and public education about risks of tobacco products, and 3) functional biomarkers of acute cardiopulmonary responses to tobacco use and secondhand smoke that may predict future disease and also support development of improved economic models. In particular, these improved economic models will integrate the rapid changes in risk due to reductions in cardiovascular and pulmonary diseases which would be expected to result from FDA regulatory decisions. This TCORS is built on the UCSF Center for Tobacco Control Research and Education's tradition of strong transdisciplinary and collaborative research, education and service. RELEVANCE: This TCORS will inform FDA regulation by developing new economic models that account for short-term and long-term effects of tobacco use, developing a better understanding of behavioral determinants of tobacco use, and identifying functional biomarkers of acute cardiopulmonary responses to tobacco use that could be used in premarket testing of tobacco products.

DESCRIPTION (provided by applicant): The overarching theme of this Tobacco Center of Regulatory Science is the development of improved models to inform tobacco product regulatory strategies that integrate 1) economic impacts of tobacco use on health costs, 2) risk perceptions, perceived acceptability, consumer responses to pro-tobacco marketing and anti-tobacco messages and other social determinants of tobacco use, and 3) rapid changes in risk due to在心血管和肺部功能障碍中表现出的烟草使用和二手烟暴露。该TCOR包括五个完整的项目（一个关于经济模型，两个有关行为模型的项目，两个关于心血管和肺部疾病模型的项目），两个开发项目（一个在行为模型上，一个在心血管和肺部疾病模型上），三个核心（行政，信息学和分析，分析，生物标记，生物标志物），一个培训后的培训计划，用于选择未来的开发项目和未来的开发项目。结果将通过提供改进的科学框架来为FDA调节烟草产品的制造，分销和营销，在该框架中，通过开发1）改进的经济模型来评估特定监管策略的可能影响，以改善经济模型，以分析拟议法规的经济模型，以说明短期以及对烟草使用的长期影响的长期影响（包括对行为和社交确定性的经济性）的长期影响（2），2）模型，营销监管和公共教育有关烟草产品风险的模型，以及3）急性心肺反应的功能性生物标志物对使用烟草的使用和二手烟雾，这可能预测未来的疾病，并支持改善经济模型的发展。特别是，这些改进的经济模型将由于减少心血管和肺部疾病的降低而导致风险的快速变化，这预计会导致FDA监管决策。该TCOR建立在UCSF烟草控制研究中心，教育的传统是强大的跨学科和协作研究，教育和服务。 相关性：该TCOR将通过开发新的经济模型来告知FDA调节，这些模型可以解释烟草使用的短期和长期影响，对使用烟草使用的行为决定因素有更好的了解，并确定可用于烟草测试的烟草使用的急性心肺反应的功能性生物标记物。