Long-Term Follow-up Core

长期跟进核心

• 批准号: 8277828
• 负责人: PAUL J MARTIN
• 金额: $ 45.83万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8277828
• 关键词: Aftercare; Applications Grants; Blood; Cancer Survivor; Cell Transplantation; Cessation of life; Clinical Research; Clinical Trials; Data; Data Base Management; Data Collection; Development; Disease; Enrollment; Fred Hutchinson Cancer Research Center; Goals; Grant; Health; Hematopoietic; Individual; Infection; Late Effects; Malignant Neoplasms; Marrow; Medical center; Methods; Multiple Myeloma; Outcome; Patients; Pediatric Hospitals; Physicians; Prospective Studies; Protocols documentation; Public Health; Recurrence; Research; Research Personnel; Research Project Grants; Retrospective Studies; Risk Factors; Second Primary Cancers; Specific qualifier value; System; Time; Universities; Washington; adult leukemia; base; cancer care; chronic graft versus host disease; cohort; follow-up; health related quality of life; improved; leukemia/lymphoma; new technology; novel strategies; prevent; programs; prospective; research study; survivorship

Core F: Long-Term Follow-Up. This core supports Projects 1- 6 by collecting long-term follow-up data for patients who have had hematopoietic cell transplantation at the Seattle Cancer Care Alliance, University of Washington Medical Center or Children's Hospital and Regional Medical Center under protocols developed at the Fred Hutchinson Cancer Research Center as part of clinical research studies sponsored by this program. The data provided through Core F are required for a variety of critically important purposes by projects in this program: 1) capture of longer-term outcomes, including the occurrence of chronic GVHD, infections, recurrent or progressive malignancy, secondary malignancy and other anticipated late complications, as well as dates of last contact and death for patients enrolled in prospective research trials, 2) capture of similar observational data for patients not enrolled in prospective studies, to be used for retrospective studies, 3) capture of observational data to be used for planning new clinical trials, and 4) capture of survivorship information to identify previously unrecognized late effects. A variety of mechanisms will be used to support these goals. a) We will continue to collect long-term data focused on survival, therapy-related complications, health and health-related quality of life relevant to the clinical research studies sponsored by this grant. These data concern the retrospective cohort of patients currently in follow-up from previous studies and the prospective cohort of patients to be enrolled .in studies described in Projects 1 - 6 of this grant application. For this purpose, a system has been established to track and maintain contact with patients and referring physicians so that data can be collected at specified time points after treatment. b)We will continue to assist investigators in obtaining long-term data specifically needed for individual research projects. c) We will continue to evaluate the methods employed in data collection and database management, identify barriers that interfere with long-term follow-up, and explore new technology to improve the efficiency and reliability of data collection and the validity and utility of the data. Relevance to Public Health: The data generated from this core unit will assist project leaders in the identification of late complications In patients who have had blood or marrow cell transplantation for treatment of leukemia, lymphoma, myeloma and other related disorders. The data will also provide the basis for hypothesis-driven research concerning risk factors for late complications, the mechanisms leading to late complications, and the development of new approaches for preventing and managing late complications among cancer survivors.

核心 F：长期跟进。该核心通过收集长期跟踪数据来支持项目 1-6 在西雅图癌症治疗联盟、西雅图大学接受过造血细胞移植的患者 华盛顿医疗中心或儿童医院和地区医疗中心已制定协议 在 Fred Hutchinson 癌症研究中心，作为该基金会赞助的临床研究的一部分 程序。通过 Core F 提供的数据用于各种极其重要的目的 该计划中的项目：1）捕获长期结果，包括慢性 GVHD 的发生， 感染、复发性或进行性恶性肿瘤、继发性恶性肿瘤和其他预期的晚期恶性肿瘤 参加前瞻性研究试验的患者的并发症以及最后一次接触和死亡的日期， 2) 获取未参加前瞻性研究的患者的类似观察数据，用于 回顾性研究，3) 捕获用于规划新临床试验的观察数据，以及 4) 捕获幸存者信息以识别以前未识别的后期影响。多种机制 将用于支持这些目标。 a) 我们将继续收集长期数据，重点关注生存、治疗相关并发症、健康和 与本补助金资助的临床研究相关的健康相关生活质量。这些数据 关注目前正在对之前的研究进行随访的患者的回顾性队列以及 纳入本资助项目 1 - 6 中描述的研究的前瞻性患者队列 应用。为此，建立了一个系统来跟踪和保持与患者的联系 转诊医生，以便在治疗后的特定时间点收集数据。 b)我们将继续协助调查人员获取个人特别需要的长期数据 研究项目。 c) 我们将继续评估数据收集和数据库管理所采用的方法， 找出干扰长期随访的障碍，并探索新技术来改善 数据收集的效率和可靠性以及数据的有效性和实用性。 与公共卫生的相关性：该核心单元生成的数据将协助项目负责人 识别接受血液或骨髓细胞移植的患者的晚期并发症 治疗白血病、淋巴瘤、骨髓瘤和其他相关疾病。数据也将提供依据 对于有关晚期并发症危险因素的假设驱动研究，导致晚期并发症的机制 并发症，以及预防和管理晚期并发症的新方法的开发 在癌症幸存者中。