Targeted Clinical Trials for Antimicrobial Resistance

抗生素耐药性的靶向临床试验

• 批准号: 8844909
• 负责人: VANCE FOWLER
• 金额: $ 379.7万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-03 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8844909
• 关键词: Adult; Algorithms; Antibiotics; Antimicrobial Resistance; Blood; Clinical Trials; Comparative Study; Drug Exposure; Drug resistance; Genus staphylococcus; Infection; Patients; Probability; Randomized; Regimen; Safety; Staphylococcal Infections; Stream; Therapeutic; Translational Research; Vancomycin; design; open label; safety testing; therapeutic effectiveness

To evaluate strategies that test the safety and effectiveness of therapeutic approaches/regimens to reduce the probability of the emergence of antibiotic drug resistance by minimizing unnecessary drug exposure. Trial title: A Multi-Center, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of a Treatment Algorithm to Reduce the Use of Vancomycin in Adult Patients With Blood Stream Infections Due to Staphylococci.

评估测试治疗方法/方案的安全性和有效性的策略，通过最大限度地减少不必要的药物暴露来降低抗生素耐药性出现的可能性。试验标题：一项多中心、随机、开放标签的比较研究，旨在评估减少葡萄球菌血流感染成人患者使用万古霉素的治疗算法的安全性和有效性。