NIH-Owned Chimpanzee Research Resource at the SNPRC

NIH 拥有的 SNPRC 黑猩猩研究资源

• 批准号: 8328712
• 负责人: JOHN L VANDEBERG
• 金额: $ 52.31万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-05 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8328712
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Biochemical; Biomedical Research; Caring; Characteristics; Clinical; Cognition; Communicable Diseases; Communities; Complex; Data; Databases; Disease; Evolution; Experimental Designs; Future; Gene Expression Profile; Genes; Genetic; Genomics; HIV; Health; Health Status; Heart Diseases; Hepatitis; Hepatitis B Virus; Hepatitis C virus; Human; Human immunodeficiency virus test; Individual; Infection; Liver; Measures; Messenger RNA; MicroRNAs; Modeling; National Center for Research Resources; Pan Genus; Peripheral Blood Mononuclear Cell; Pharmaceutical Preparations; Physiological; Physiology; Play; Pongidae; Population; Prevention; Primates; Recording of previous events; Relative (related person); Research; Research Personnel; Research Subjects; Resources; Role; Sampling; Schedule; Testing; Time; United States National Institutes of Health; Variant; cohort; design; efficacy testing; genome sequencing; humanized monoclonal antibodies; infectious disease treatment; man; novel therapeutic intervention; programs; public education; safety testing

DESCRIPTION (provided by applicant): The genetic, physiological, biochemical, and immunological similarities of chimpanzees to humans make them unique models for biomedical research directed at many aspects of human health including, among others, developing preventions and treatments for infectious diseases (e.g., HBV, HCV, HIV), testing the effects of drugs specifically designed for use in humans, and testing the safety and efficacy of humanized monoclonal antibodies. The overall objective of this project is to maintain an NCRR-owned research resource consisting of 209 chimpanzees and to manage it to serve the national biomedical research needs. We will pursue the following specific aims: 1) To maintain a stable, healthy, well defined population of chimpanzees and to make them available for research; 2) To maintain a cohort of well characterized chimpanzees persistently infected with HBV, HCV or HIV for research on hepatitis and AIDS and for testing the efficacy of new therapeutic approaches; 3) To develop a unique resource of fully sequenced transcriptomes from liver samples of all 209 chimpanzees, including mRNAs and microRNAs, and from PBMC samples of a subset of 36 chimpanzees that are chronically infected with HCV or that have cleared the infection; 4) To develop longitudinal quantitative measures of physiological characteristics that are of importance to biomedical research and to analyze them in relation to sequence data from Aim 3 and in relation to health status; 5) To develop a data base that contains information about the chimpanzees and the data obtained under Aims 3 and 4, and to make it available to the national biomedical research community for research purposes and for selection of experimental subjects; 6) To establish a program for educating the public as to the importance of chimpanzees in biomedical research. Via fulfilling these aims, we will establish a chimpanzee resource that is unique among all chimpanzee research resources in enabling investigators for the first time to exploit genome sequence data from individual chimpanzees in experimental design and in genomic analyses. In addition, the educational program will contribute to the public's understanding of the care and use of chimpanzees in biomedical research, and the need for resources such as the one proposed in this application.

描述（由申请人提供）：黑猩猩与人类在遗传、生理、生化和免疫学方面的相似性使它们成为针对人类健康许多方面的生物医学研究的独特模型，其中包括开发传染病的预防和治疗方法（例如， HBV、HCV、HIV），测试专门设计用于人类的药物的效果，并测试人源化单克隆抗体的安全性和有效性。该项目的总体目标是维护 NCRR 拥有的由 209 只黑猩猩组成的研究资源，并对其进行管理以满足国家生物医学研究需求。我们将追求以下具体目标： 1）维持稳定、健康、明确的黑猩猩种群并使其可供研究； 2) 维持一组特征明确、持续感染 HBV、HCV 或 HIV 的黑猩猩，用于肝炎和艾滋病研究以及测试新治疗方法的功效； 3) 从所有 209 只黑猩猩的肝脏样本（包括 mRNA 和 microRNA）以及 36 只慢性感染 HCV 或已清除感染的黑猩猩的 PBMC 样本中开发完全测序转录组的独特资源； 4) 开发对生物医学研究重要的生理特征的纵向定量测量，并根据目标 3 的序列数据和健康状况对其进行分析； 5) 开发一个数据库，其中包含有关黑猩猩的信息以及根据目标 3 和 4 获得的数据，并将其提供给国家生物医学研究界用于研究目的和选择实验对象； 6) 制定一项计划，教育公众了解黑猩猩在生物医学研究中的重要性。通过实现这些目标，我们将建立一个在所有黑猩猩研究资源中独一无二的黑猩猩资源，使研究人员能够首次在实验设计和基因组分析中利用个体黑猩猩的基因组序列数据。此外，该教育计划将有助于公众了解生物医学研究中黑猩猩的护理和使用，以及对本申请中提出的资源的需求。