Photoacoustic Micro-Imaging system for Shared Tumor Imaging Resource at Roswell P

Roswell P 共享肿瘤成像资源的光声微成像系统

基本信息

批准号：
8247498
负责人：
Mukund Seshadri
金额：
$ 59.6万
依托单位：
ROSWELL PARK CANCER INSTITUTE CORP
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-15 至 2013-05-14
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The purpose of this NCRR Shared Instrument Grant application is to secure funding to purchase a Small Animal Photoacoustic Imaging system (Vevo(R)LAZR) for the Shared Tumor Imaging Resource (STIR) at Roswell Park Cancer Institute (RPCI). The STIR at RPCI provides customized scientific and technical small animal imaging services on a fee for service basis to NIH funded investigators at RPCI, the State University of New York at Buffalo (SUNY-Buffalo) and neighboring academic institutions in Western New York. Since 2005, the STIR has seen a steady growth in its utilization as a result of increased awareness of its imaging technologies achieved through active collaborations with institutional faculty and educational outreach programs instituted by STIR and RPCI. However, this positive change has also highlighted the need for state- of-the-art imaging technology to meet the expanding needs of RPCI research community. The Vevo LAZR platform is a high sensitivity system specifically designed for small animal imaging at a high resolution. In addition to anatomic or morphologic assessment of tumors, the system allows for molecular functional imaging of the tumor microenvironment in small animal models of disease. The sophisticated software platform allows for visualization and quantitative analysis of imaging datasets in an efficient and user-friendly manner. With the increased interest in personalized medicine and molecular targeted therapies for cancer, several NIH-funded programs at RPCI and SUNY-Buffalo are focused on understanding the changes in the tumor microenvironment during malignant progression and following therapy. These projects, some of which have been detailed in this application, will utilize the Vevo(R)LAZR system to (i) detect occult metastatic lesions in disease sites such as the kidney and liver, (ii) assess longitudinal changes in tumor morphology following treatment, (iii) visualize and quantify changes in tumor blood flow, (iv) map sentinel lymph nodes and lymphatics, (v) measure parameters such as oxygenation and hemoglobin saturation in tumors, and, (vi) investigate tumor-targeting ability of multifunctional nanoparticle. The availability of a user-friendly, portable imaging system at STIR would enable its users to effectively combine high-throughput anatomic imaging with quantitative, functional molecular imaging of tumors. Acquisition of the photoacoustic imaging system will not only enable STIR to meet the existing demand for this imaging technology but also facilitate further growth of STIR by increasing its imaging services and technologies available to researchers. PUBLIC HEALTH RELEVANCE: A high-resolution, high sensitivity photoacoustic imaging system is requested for the Shared Tumor Imaging Resource at Roswell Park Cancer Institute (RPCI). The availability of a user-friendly, portable imaging system would enable multiple NCI/NIH-funded investigators at RPCI to effectively combine high throughput anatomic imaging with quantitative, functional molecular imaging for cancer research applications.

描述（由申请人提供）：此 NCRR 共享仪器拨款申请的目的是确保获得资金来购买小动物光声成像系统 (Vevo(R)LAZR)，用于罗斯威尔公园癌症研究所 (STIR) 的共享肿瘤成像资源 (STIR)。 RPCI）。 RPCI 的 STIR 向 NIH 资助的 RPCI、纽约州立大学布法罗分校 (SUNY-Buffalo) 和纽约西部邻近学术机构的研究人员提供按服务收费的定制科学和技术小动物成像服务。自 2005 年以来，STIR 的利用率稳步增长，这是通过与机构教师的积极合作以及 STIR 和 RPCI 制定的教育推广计划提高了对其成像技术的认识。然而，这一积极变化也凸显了对最先进成像技术的需求，以满足 RPCI 研究界不断扩大的需求。 Vevo LAZR 平台是一款高灵敏度系统，专为高分辨率小动物成像而设计。此外为了对肿瘤进行解剖或形态学评估，该系统可以对小动物疾病模型中的肿瘤微环境进行分子功能成像。先进的软件平台允许以高效且用户友好的方式对成像数据集进行可视化和定量分析。随着人们对癌症个性化医疗和分子靶向治疗的兴趣日益浓厚，RPCI 和纽约州立大学布法罗分校的多个 NIH 资助项目专注于了解恶性进展期间和治疗后肿瘤微环境的变化。这些项目（其中一些已在本申请中详细介绍）将利用 Vevo(R)LAZR 系统 (i) 检测以下部位的隐匿性转移病灶：疾病部位，如肾脏和肝脏，(ii) 评估治疗后肿瘤形态的纵向变化，(iii) 可视化和量化肿瘤血流的变化，(iv) 绘制前哨淋巴结和淋巴管图，(v) 测量参数，例如肿瘤中的氧合和血红蛋白饱和度，以及（vi）研究多功能纳米粒子的肿瘤靶向能力。 STIR 提供用户友好的便携式成像系统，使其用户能够有效地将高通量解剖成像与肿瘤的定量功能分子成像结合起来。收购光声成像系统不仅将使 STIR 能够满足对该成像技术的现有需求，而且还可以通过增加研究人员可用的成像服务和技术来促进 STIR 的进一步发展。公共健康相关性：罗斯威尔帕克癌症研究所 (RPCI) 的共享肿瘤成像资源需要高分辨率、高灵敏度光声成像系统。用户友好的便携式成像系统的可用性将使 RPCI 的多名 NCI/NIH 资助的研究人员能够有效地将高通量解剖成像与定量功能分子成像结合起来，用于癌症研究应用。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Photoacoustic monitoring of tumor and normal tissue response to radiation.

肿瘤和正常组织对辐射反应的光声监测。

DOI：
发表时间：
2016-02-17
期刊：
影响因子：
4.6
作者：
Rich, Laurie J;Seshadri, Mukund
通讯作者：
Seshadri, Mukund

Photoacoustic imaging of salivary glands.

唾液腺的光声成像。

DOI：
发表时间：
2015-09-01
期刊：
影响因子：
3.4
作者：
Rich, Laurie J;Seshadri, Mukund
通讯作者：
Seshadri, Mukund

Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines.

使用冷冻胶束萘酞菁对肠道进行非侵入性多模态功能成像。

DOI：
发表时间：
2014-08
期刊：
影响因子：
38.3
作者：
Zhang, Yumiao;Jeon, Mansik;Rich, Laurie J;Hong, Hao;Geng, Jumin;Zhang, Yin;Shi, Sixiang;Barnhart, Todd E;Alexandridis, Paschalis;Huizinga, Jan D;Seshadri, Mukund;Cai, Weibo;Kim, Chulhong;Lovell, Jonathan F
通讯作者：
Lovell, Jonathan F

Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer.

多模态成像指导前列腺癌血管靶向的临床前试验。