Acquisition of a 7T MR scanner for Translational Imaging Research at Roswell Park

购买一台 7T MR 扫描仪用于罗斯威尔公园的转化成像研究

• 批准号: 10176803
• 负责人: Mukund Seshadri
• 金额: $ 200万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176803
• 关键词: 20 year old; Aging; Applications Grants; Buffaloes; Comprehensive Cancer Center; Custom; Electronics; Faculty; Failure; Fee-for-Service Plans; Functional Imaging; Funding; Growth; Image; Imaging technology; Institution; Investigation; Magnetic Resonance Imaging; New York; Oncology; Radiology Specialty; Research; Research Personnel; Resource Sharing; Risk; S10 grant; Secure; Services; United States National Institutes of Health; Universities; anatomic imaging; cancer imaging; faculty research; instrument; member; molecular imaging; pre-clinical research; preclinical imaging; prevent; programs

Project Summary The purpose of this S10 grant application is to secure funding to replace a technically outdated 4.7T magnetic resonance imaging (MRI) scanner for the Translational Imaging Shared Resource (TISR) at Roswell Park Comprehensive Cancer Center. For nearly two decades, the TISR at Roswell Park has been providing customized scientific and technical preclinical imaging services on a fee for service basis to NIH funded investigators at Roswell Park, the State University of New York at Buffalo and neighboring academic institutions in Western New York. It is a heavily utilized by over 50 Roswell Park and UB faculty members who are conducting basic and translational investigations in oncology and radiology. The existing 4.7T magnet was purchased through a combination of institutional and state funds and was the first MR scanner installed in WNY dedicated for preclinical research. Since 2001, TISR has catered to the imaging needs of 168 users, out of whom 105 utilized the existing 4.7T MR scanner. However, this aging instrument has encountered two soft quenches in the last 10 years, and has outdated electronics that lack upgrading capabilities. These limitations pose a significant risk to faculty and research programs at the only NCI designated Comprehensive Cancer Center in the state of New York outside of Manhattan. Another technical failure of the present ~20-year-old MR scanner would be catastrophic and seriously jeopardize the conduct of active NIH/NCI funded research at Roswell Park and prevent our faculty from pursuing new projects utilizing MRI for anatomic, functional and molecular imaging of cancer. Acquisition of an upgraded instrument is therefore a critical need that will not only enable TISR to meet the existing demand for this imaging technology but also facilitate further growth of TISR.

项目概要 此 S10 拨款申请的目的是获得资金来更换技术上过时的 4.7T 磁力发动机 用于罗斯威尔公园转化成像共享资源 (TISR) 的共振成像 (MRI) 扫描仪 综合癌症中心。近二十年来，罗斯威尔公园的 TISR 一直在提供 向 NIH 资助的按服务收费的定制科学和技术临床前成像服务 罗斯威尔公园、纽约州立大学布法罗分校和邻近学术机构的研究人员 纽约州西部的机构。它被超过 50 名罗斯威尔帕克大学和布法罗大学教职员工广泛使用。 正在肿瘤学和放射学领域进行基础和转化研究。现有4.7T磁铁为 通过机构和国家资金联合购买，是安装在 WNY 致力于临床前研究。自 2001 年以来，TISR 已满足了 168 个用户的成像需求，超过 其中 105 人使用现有的 4.7T MR 扫描仪。然而，这款老化仪器却遇到了两个软 过去 10 年已经过时，并且电子设备已经过时，缺乏升级能力。这些限制 对 NCI 唯一指定的综合癌症中心的教师和研究项目构成重大风险 位于纽约州曼哈顿郊外的中心。 20岁左右的MR的又一个技术故障 扫描仪将是灾难性的，并严重危害 NIH/NCI 资助的活跃研究的进行 罗斯威尔公园，并阻止我们的教师利用 MRI 进行解剖学、功能性和功能性研究的新项目 癌症的分子成像。因此，购买升级的仪器是一项迫切需要，这不仅会 使 TISR 能够满足对该成像技术的现有需求，同时也促进 TISR 的进一步发展。