Prospective/Retrospective Motion Correction System for Motion Robust Pediatric MR

用于运动鲁棒儿科 MR 的前瞻性/回顾性运动校正系统

• 批准号: 8641416
• 负责人: Erez Nevo
• 金额: $ 58.19万
• 依托单位: ROBIN MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-26 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8641416
• 关键词: Adoption; Adult; Adverse event; Affect; Algorithms; Anesthesia procedures; Boston; Brain; Brain imaging; Capital Expenditures; Charge; Child; Childhood; Clinical; Clinical Research; Computer Workstations; Computer software; Data; Development; Devices; Diagnosis; Diagnostic; Diffusion weighted imaging; Ensure; Evaluation; General Anesthesia; Goals; Health Care Costs; Hospitals; Image; Imaging technology; Immune; Individual; Intervention; Joints; Longevity; Magnetic Resonance Imaging; Marketing; Measures; Medical; Mental disorders; Methodology; Methods; Modeling; Motion; Movement; Neurobiology; Noise; Operative Surgical Procedures; Patients; Pediatric Hospitals; Pediatric Research; Performance; Phase; Physiologic pulse; Population; Positioning Attribute; Prevention; Process; Radiology Specialty; Research; Resolution; Resources; Risk; Robin bird; Running; Sales; Scanning; Sedation procedure; Signal Transduction; Small Business Technology Transfer Research; Stroke; System; Testing; Three-Dimensional Image; Time; Tuberous Sclerosis; Weight; base; brain research; clinical care; clinical research site; cost; improved; insight; prospective; reconstruction; research clinical testing; research study; sensor; tool; volunteer

DESCRIPTION (provided by applicant): The long term objective of the project is to develop a new motion robust magnetic resonance imaging (MRI) technology. Magnetic resonance imaging is a powerful tool that aids in the diagnosis of individual subjects, guides their clinical care, ad provides insights into the mechanisms of normal and atypical development. The characterization of mental health disorders across the lifespan has been facilitated by brain MRI. However, conventional magnetic resonance imaging requires the subject being imaged remain perfectly still for the duration of the image encoding. Young children and non-cooperative adult patients have difficulty to hold still long enough for successful imaging. For clinical imaging such patients are frequently sedated or anesthetized, which runs the risk of adverse events, is costly, and does not ensure the subjects remain perfectly still. Research studies are typically unable to use sedation or anesthesia due to its significant risk. This hampers our ability to identify the neurobiological underpinnings of mental health disorders. The development of motion robust magnetic resonance imaging will enable dramatic improvements in our capacity to chart the trajectory of mental illness over the lifespan. This will have a significant impact on our ability to determine when, where and how to intervene, and enable improved evaluation of potential interventions. The project proposes to utilize a combination of hardware for prospective motion tracking during scan and post-acquisition processing with scattered data interpolation to enable the construction of high resolution high signal-to-noise ratio images of the brain from subjects who are unable to hold still. The specific aims of this Phase II STTR application are: (1) to modify the EndoScout tracking system to enable realtime motion tracking on any scanner, with no hardware connections to the scanner and with no software changes in the scanner; (2) to accelerate retrospective processing time to achieve rapid reconstruction of motion-free 3D image set and thus to enable clinical evaluation of the scans before the subject is taken out of the scanner; (3) to apply the method to additional sequences that are needed for clinical use of the system; (4) to conduct technical tests with a moving phantom and volunteer tests to verify the performance of the system before its being used in the clinical studies: (5) to conduct a two-phase clinical study of the system, including a "try first without sedation" study in the general pediatric population and in Tuberous Sclerosis patients. This is a joint project by Robin Medical, Inc., which will develop the motion tracking system and the accelerated processing software and will conduct technical tests of the system; and the Research Section at the Department of Radiology, Children's Hospital Boston, which will develop the imaging sequences and will conduct the volunteer and clinical studies of the project.

描述（由申请人提供）：该项目的长期目标是开发一种新的运动稳健磁共振成像（MRI）技术。磁共振成像是一种有助于诊断单个受试者的功能强大的工具，指导其临床护理，AD提供了有关正常和非典型发育机制的见解。大脑MRI促进了整个生命周期的精神健康障碍的表征。但是，传统的磁共振成像需要在图像编码的过程中，要成像的受试者仍然完全静止。幼儿和非合作的成年患者难以保持足够长的时间来成功成像。对于临床成像，这种患者经常被镇静或麻醉，这会有不良事件的风险，并且不能确保受试者保持完美静止。由于其重大风险，研究通常无法使用镇静或麻醉。这阻碍了我们识别精神疾病的神经生物学基础的能力。运动稳健的磁共振成像的发展将使我们能够在整个生命周期内绘制精神疾病轨迹的能力进行巨大改进。这将对我们确定何时，何处和如何干预的能力产生重大影响，并能够改善对潜在干预措施的评估。该项目建议将硬件的组合用于扫描期间的前瞻性运动跟踪和散布数据插值，以构建高分辨率的高信噪比大脑的高信噪比图像，这些受试者无法从无法保持静止状态的受试者中构建。该II阶段STTR应用程序的具体目的是：（1）修改内科武器跟踪系统以在任何扫描仪上启用实时运动跟踪，而没有与扫描仪的硬件连接，并且扫描仪没有任何软件更改； （2）加速回顾性处理时间，以快速重建无运动3D图像集，从而在将受试者从扫描仪中取出之前对扫描进行临床评估； （3）将方法应用于系统临床使用所需的其他序列； （4）通过移动的幻影和志愿者测试进行技术测试，以验证该系统在临床研究中使用之前的性能：（5）对系统进行两阶段的临床研究，包括在普通儿科人群中进行“不先尝试镇静”研究，并在结核病患者中进行。这是Robin Medical，Inc。的联合项目，该项目将开发运动跟踪系统和加速处理软件，并将对系统进行技术测试；以及波士顿儿童医院放射学系的研究科，该部门将开发成像序列，并将进行该项目的志愿者和临床研究。

项目成果

Passive fMRI mapping of language function for pediatric epilepsy surgical planning: validation using Wada, ECS, and FMAER.

• DOI: 10.1016/j.eplepsyres.2014.09.016
• 发表时间: 2014-12
• 期刊: Epilepsy research
• 影响因子: 2.2
• 作者: Suarez RO;Taimouri V;Boyer K;Vega C;Rotenberg A;Madsen JR;Loddenkemper T;Duffy FH;Prabhu SP;Warfield SK
• 通讯作者: Warfield SK