MRI-mediated radiofrequency ablation

MRI介导的射频消融

• 批准号: 7304445
• 负责人: Erez Nevo
• 金额: $ 38.38万
• 依托单位: ROBIN MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7304445
• 关键词: Ablation; Achievement; Animal Experiments; Animals; Breast; Catheters; Clinical; Clinical Research; Coagulation Process; Collaborations; Deposition; Development; Devices; Electrodes; Electromagnetics; Equilibrium; Equipment; Frequencies; General Hospitals; Generations; Hand; Healthcare Systems; Heating; Image; Implant; Invasive; Kidney; Lasers; Lesion; Liver neoplasms; Lung; Magnetic Resonance Imaging; Massachusetts; Mediating; Medical; Medical Imaging; Modality; Monitor; Operative Surgical Procedures; Outpatients; Patients; Phase; Procedures; Prostate; Protons; Radio; Radiofrequency Interstitial Ablation; Recovery; Resectable; Risk; Risk Factors; Robin bird; Safety; Scanning; Solutions; System; Techniques; Technology; Temperature; Thermal Ablation Therapy; Tissues; Ultrasonography; United States Food and Drug Administration; Work; animal tissue; base; clinical application; concept; cost; heat injury; imaging probe; in vivo; microwave electromagnetic radiation; new technology; prototype; radiofrequency; research study; transmission process

DESCRIPTION (provided by applicant): The objective of the proposed project is to develop an RF ablation technique for use with MRI scanners. In addition to providing image-guidance to the procedure, the scanner will also provide the ablation mechanism through the use of its own radio-frequency (RF) transmission to mediate tissue heating and coagulation. The specific aims of the project are: to demonstrate the feasibility of using energy deposition from native RF transmission of MRI scanner during scan to create sufficient heat for issue ablation; to conduct numerical and experimental studies to define the optimal solution for MRI- guided ablation by the use of RF transmission by the scanner; to develop a self- contained prototype for RF ablation and imaging with controllable heat generation; and to conduct technical experiments and animal studies to demonstrate the ability of the probe to ablate tissues simultaneously with local MR imaging. The envisioned clinical product will be a disposable, self-contained, ablation probe that can be used on any MRI scanner for various clinical applications. Using the large installed base of close to 10,000 scanners in the USA, the new technology will provide a nation-wide public access to an advanced, minimally invasive technology for various clinical procedures, including ablation of various tumors (liver, lung, breast, prostate, kidney). The technology will be developed through collaboration between Robin Medical, Inc., that will develop the new ablation device, and a team at the Massachusetts General Hospital that will support the initial analysis of the different potential embodiments of the concept and the experimental work with the device prototypes. The proposed project aims to develop an ablation (heating) technique that is based on the use of magnetic resonance imaging (MRI) to guide and to conduct the procedure. As MRI is the best means to produce medical images to guide RF (radiofrequency energy) ablation on one hand, and as there is wide public accessibility to MRI scanners throughout the USA on the other hand, this technology will enable nation-wide access to RF ablation. Because this minimally invasive procedure is typically done as an outpatient procedure, it replaces open surgical procedures, and thus may help to decrease the expenses of the healthcare system and to contribute to lower risk, reduced discomfort and speedier recovery of patients.

描述（由申请人提供）：拟议项目的目的是开发用于与MRI扫描仪一起使用的RF消融技术。除了为程序提供图像指导外，扫描仪还将通过使用自己的射频（RF）传输来介导组织加热和凝结，还将提供消融机制。该项目的具体目的是：证明在扫描过程中使用MRI扫描仪的天然RF传播的能量沉积的可行性，以产生足够的热量来消融；进行数值和实验研究以通过扫描仪使用RF传输来定义用于擦拭的最佳解决方案；开发一个自我包含的原型，用于以可控制的热量产生射频和成像；并进行技术实验和动物研究，以证明探针与局部MR成像同时消融组织的能力。设想的临床产品将是一次性，独立的消融探针，可用于任何MRI扫描仪用于各种临床应用。新技术使用近10,000个扫描仪的大型安装底座，将为各种临床程序提供对先进的，微创的技术的公众访问，包括消融各种肿瘤（肝脏，肺，乳房，前列腺，前列腺，肾脏）。该技术将通过Robin Medical，Inc。之间的合作开发，该公司将开发新的消融设备，以及马萨诸塞州综合医院的团队，该团队将支持对该概念的不同潜在实施方案以及使用设备原型的实验性工作的初步分析。拟议的项目旨在开发一种基于磁共振成像（MRI）指导和执行程序的消融（加热）技术。由于MRI是制作医疗图像以指导RF（射频能量）消融的最佳手段，而且由于在美国各地都有广泛的公共访问性可访问MRI扫描仪，因此这项技术将使全国范围内的RF消融访问。由于这种微创手术通常是作为门诊手术的，因此它取代了开放手术程序，因此可能有助于减少医疗保健系统的费用，并促进降低风险，减少不适和速度较高的患者康复。