COBRE Center for Neurodegenerative Disorder Research

COBRE 神经退行性疾病研究中心

基本信息

批准号：
8685284
负责人：
Jonathan David Geiger
金额：
$ 102.83万
依托单位：
UNIVERSITY OF NORTH DAKOTA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-15 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8685284
关键词：
Accounting Advisory Committees Anatomy Cellular biology Centers of Research Excellence Commit Communities Confocal Microscopy Core Facility Data Electron Microscope Electron Microscopy Ensure Equipment Extramural Activities Faculty Fluorescence Fluorescence Resonance Energy Transfer Fostering Functional disorder Funding Future Grant Health Science Library Health Sciences High Pressure Liquid Chromatography Housing Image Image Analysis Ions Libraries Life Literature Manuscripts Mass Spectrum Analysis Measures Mentors Mentorship Microscope Microtome - medical device Molecular Weight National Center for Research Resources Neurodegenerative Disorders Neurosciences Neurosciences Research North Dakota Pathogenesis Pharmacology Phase Physiology Positioning Attribute Principal Investigator Publishing Recruitment Activity Reporting Research Research Personnel Scanning Series Spectrum Analysis Structure System Therapeutic Therapeutic Intervention Universities Visit Water cost drug metabolism fluorescence microscope instrumentation light microscopy mass spectrometer medical schools meetings member metabolomics microbial alkaline proteinase inhibitor professor programs ratiometric small molecule success symposium transmission process two-photon

项目摘要

DESCRIPTION (provided by applicant): Neurodegenerative disease research is one of UND's few recognized strengths as identified in 3 separate Strategic research reports. This COBRE Phase 111 funding request will support our neurodegenerative disease research group's administrative core, pilot grant program, and our mass spectrometry and imaging cores. Our COBRE group continues to focus on determining mechanisms responsible for the pathogenesis of and identifying possible therapeutic interventions against neurodegenerative disorders. Since our COBRE funding started 9 years ago, we supported 11 project directors, we developed and supported two cores, we supported the hiring of 9 neuroscience faculty, and we supported with pilot grants 16 neuroscience investigators. COBRE investigators received about $11M in extramural grants, published 242 manuscripts, and a new Neuroscience Research Building was built. Our Mass Spectrometry Core Facility is used almost exclusively for small molecule analysis including metabolomics, lipidomics, drug metabolism, molecule structure identification, and small molecule quantification. The equipment housed in our facility includes a new Waters Synapt G2 QTOF with UPLC and Nanomate, an API-3000 triple quadripole with HPLC, a QSTAR with nanoLC, a Polaris Q ion trap with GC, and a Beckman 2-D HPLC. Our Imaging Core Facility provides access to fluorescence, confocal, multiphoton, and electron microscopy instrumentation. The equipment housed in our facility includes two confocal microscopes (Zeiss 510 META LSCM, Olympus FV300 LSCM), a Zeiss ConfoCor2 fluorescence correlation spectroscopy unit, an Olympus FV1000MPE Basic multiphoton/visible confocal microscope system, and two fluorescence microscopes (Nikon TE300 equipped for FURA2 and CFP/YFP FRET ratiometric imaging, and a Nikon Eclipse 801). For electron microscopy, we have a scanning (Hitachi 4700) and a transmission (Hitachi 7500) electron microscope, Reichert ultra-microtomes, and a range of ancillary equipment. The COBRE grant-supported neurodegenerative disease research group has been supported strongly by UND, our successes are recognized by UND, and UND is fully committed to helping sustain our efforts after COBRE funding ends.

描述（由申请人提供）：神经退行性疾病研究是UND在3份单独的战略研究报告中确定的几个公认优势之一。这个毛cre期111阶段的资金要求将支持我们的神经退行性疾病研究小组的行政核心，试点赠款计划以及我们的质谱和成像核心。我们的毛线组继续专注于确定负责对神经退行性疾病的可能治疗干预措施的发病机理的机制。自从9年前我们的手工资金开始以来，我们支持11名项目主管，我们开发并支持了两个核心，我们支持了9位神经科学教师的聘用，并支持了Pilot Grants 16位神经科学研究人员。手工研究人员收到了大约1100万美元的校外赠款，出版了242份手稿，并建造了新的神经科学研究大楼。我们的质谱核心设施几乎完全用于小分子分析，包括代谢组学，脂质组学，药物代谢，分子结构鉴定和小分子定量。我们设施中包含的设备包括带有UPLC和纳米酸盐的新水域G2 QTOF，带有HPLC的API-3000三二极管，带有Nanolc的QSTAR，带有GC的Polaris Q ion Trap，带有GC的Polaris Q ion陷阱，以及Beckman 2-D HPLC。我们的成像核心设施可访问荧光，共聚焦，多光子和电子显微镜仪器。我们设施中容纳的设备包括两个共聚焦显微镜（Zeiss 510 Meta LSCM，Olympus FV300 LSCM），一个Zeiss Compocor2荧光相关光谱单元，Olympus FV1000MPE基本多螺旋子/可见的多核系统和两个荧光模型（NIKON CORURSICTICER MICRSCEMS（NIKON）（NIKON）（NIKON）（NIKON） CFP/YFP FRET比率成像和Nikon Eclipse 801）。对于电子显微镜，我们进行了扫描（Hitachi 4700）和传输（Hitachi 7500）电子显微镜，Reichert Ultra-Microtomes和一系列辅助设备。 UND得到了强有力的支持，由UND认可了我们的成功，UND完全致力于在Cobre资助结束后帮助我们维持我们的努力。