Contribution of dopamine to risk attitude across the lifespan

多巴胺对整个生命周期风险态度的贡献

基本信息

批准号：
8733509
负责人：
Paul E. M. Phillips
金额：
$ 35.15万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-30 至 2015-05-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Individuals in our society are required to make complex economic choices, often with uncertain outcomes, by integrating large amounts of information available to inform those choices. This daily requirement for decision making at all stages of life, together with increasing life spans and a growing accessibility to information among the youngest and eldest members of society, makes an evaluation of potential differences in decision making across age groups a critical area of research. Choosing advantageously among competing options with certain and uncertain outcomes is a product of individual subjective valuation of rewarding outcomes and the reinforcement learning processes required for accurately estimating those outcomes based on predictive information. Accordingly, a neuroeconomic framework of decision making under risk incorporating the contribution of age-related distinctions in subjective valuation and reinforcement learning provides a powerful tool for insight into the underlying substrates of choice behavior across the lifespan. The primary goal of the proposed work is to establish behavioral and neurobiological profiles of decision making under risk across the lifespan and examine the contribution of subjective reward valuation and reinforcement learning to these profiles at different life stages. We hypothesize that developmental/maturational changes in dopamine signaling from adolescence through adulthood and senescence is a fundamental contributor to choice behavior through the age-specific encoding of these essential components to the decision-making apparatus. We propose three specific aims examining dopamine signaling in the ventral striatum during probabilistic decision making, reinforcement learning, and subjective reward valuation in adolescent, adult, and aged rats.

描述（由申请人提供）：我们社会中的个人必须通过整合可用的大量信息来告知这些选择，从而做出复杂的经济选择，通常是不确定的结果。在生活的各个阶段进行决策的日常需求，以及日益增长的生活跨度以及社会上最年轻和最大的成员之间对信息的访问，这使得对整个年龄段的决策的潜在差异评估是研究的关键领域。在竞争选择中以某些不确定的结果进行有利的选择是个人主观估值的奖励结果估值以及基于预测信息准确估算这些结果所需的强化学习过程。因此，在风险下的神经经济框架融合了与年龄相关的主观估值和强化学习中与年龄相关的区别的贡献，为您洞悉整个寿命的选择行为的基础基质提供了一种强大的工具。拟议工作的主要目标是在整个生命周期内建立风险下的决策的行为和神经生物学概况，并检查主观奖励估值和强化学习对不同生活阶段的这些概况的贡献。我们假设从青春期到成年和衰老的多巴胺信号传导的发育/成熟变化是通过对决策机构的这些基本组成部分的特定年龄编码来对选择行为的基本贡献。我们提出了三个特定的目的，以检查青少年，成人和老年大鼠的概率决策，增强学习和主观奖励评估期间腹侧纹状体中的多巴胺信号传导。