Contribution of dopamine to risk attitude across the lifespan

多巴胺对整个生命周期风险态度的贡献

基本信息

批准号：
8549099
负责人：
Paul E. M. Phillips
金额：
$ 34.09万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-30 至 2015-05-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Individuals in our society are required to make complex economic choices, often with uncertain outcomes, by integrating large amounts of information available to inform those choices. This daily requirement for decision making at all stages of life, together with increasing life spans and a growing accessibility to information among the youngest and eldest members of society, makes an evaluation of potential differences in decision making across age groups a critical area of research. Choosing advantageously among competing options with certain and uncertain outcomes is a product of individual subjective valuation of rewarding outcomes and the reinforcement learning processes required for accurately estimating those outcomes based on predictive information. Accordingly, a neuroeconomic framework of decision making under risk incorporating the contribution of age-related distinctions in subjective valuation and reinforcement learning provides a powerful tool for insight into the underlying substrates of choice behavior across the lifespan. The primary goal of the proposed work is to establish behavioral and neurobiological profiles of decision making under risk across the lifespan and examine the contribution of subjective reward valuation and reinforcement learning to these profiles at different life stages. We hypothesize that developmental/maturational changes in dopamine signaling from adolescence through adulthood and senescence is a fundamental contributor to choice behavior through the age-specific encoding of these essential components to the decision-making apparatus. We propose three specific aims examining dopamine signaling in the ventral striatum during probabilistic decision making, reinforcement learning, and subjective reward valuation in adolescent, adult, and aged rats.

描述（由申请人提供）：我们社会中的个人需要通过整合大量可用信息来做出复杂的经济选择，通常会产生不确定的结果。生命各个阶段对决策的日常需求，加上寿命的延长以及社会中最年轻和最年长成员对信息的日益获取，使得评估不同年龄组决策的潜在差异成为一个关键的研究领域。在具有确定和不确定结果的竞争选项中进行有利选择是个人对奖励结果的主观评估以及基于预测信息准确估计这些结果所需的强化学习过程的产物。因此，风险决策的神经经济学框架结合了主观评价和强化学习中与年龄相关的差异的贡献，为洞察整个生命周期选择行为的潜在基础提供了一个强大的工具。拟议工作的主要目标是建立整个生命周期中风险决策的行为和神经生物学概况，并检查主观奖励评估和强化学习对不同生命阶段这些概况的贡献。我们假设，从青春期到成年和衰老的多巴胺信号的发育/成熟变化是通过对决策机构的这些重要组成部分进行年龄特异性编码而对选择行为做出基本贡献的因素。我们提出了三个具体目标，检查青少年、成年和老年大鼠的概率决策、强化学习和主观奖励评估过程中腹侧纹状体中的多巴胺信号。