Dendritic cell directed T cell negative regulation for treating autoimmunity

树突状细胞定向 T 细胞负调节治疗自身免疫

• 批准号: 8334865
• 负责人: CHENTHAMARAKSHAN VASU
• 金额: $ 32.86万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-24 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8334865
• 关键词: Adopted; Adverse effects; Affinity; Anti-Inflammatory Agents; Anti-inflammatory; Antigen Presentation; Antigens; Attention; Autoimmune Diseases; Autoimmune Process; Autoimmune thyroiditis; Autoimmunity; Binding; Bone Marrow; CD28 gene; CD4 Positive T Lymphocytes; CD80 gene; CDR1 gene; Cell Communication; Cell Differentiation process; Cell physiology; Cells; Characteristics; Clinical; Complementary DNA; Complex; Cytotoxic T-Lymphocyte-Associated Protein 4; Dendritic Cells; Disease; Disease model; Down-Regulation; Effectiveness; Engineering; Event; Future; Generations; Goals; Graft Rejection; Hashimoto Disease; Homeostasis; Immune; Immune System Diseases; Immunization; Immunosuppressive Agents; In Vitro; Inbred NOD Mice; Individual; Inflammatory Response Pathway; Insulin-Dependent Diabetes Mellitus; Interleukin-10; Knock-in Mouse; Lead; Length; Life; Ligands; Ligation; Light; Longevity; Mediating; Memory; Methods; Modeling; Monitor; Mus; Nature; Opportunistic Infections; Orphan; Ovalbumin; Pathway interactions; Peptides; Physiologic pulse; Process; Property; Receptor Activation; Regulation; Regulatory T-Lymphocyte; Reporting; Rest; Risk; Role; Safety; Signal Transduction; Specificity; Staging; Stem cells; Surface; Synapses; System; T cell differentiation; T cell response; T-Cell Activation; T-Cell Receptor; T-Lymphocyte; Testing; Therapeutic; Therapeutic Effect; Therapeutic Studies; Therapeutic Uses; Thyroglobulin; Time; Tissues; Transgenic Mice; Wild Type Mouse; cellular engineering; cost effective; cytokine; experience; high voltage electron microscopy; in vitro testing; in vivo; inhibitor/antagonist; interest; mouse model; mutant; overexpression; prevent; public health relevance; receptor; receptor expression; research study; response; tool