LIPIDOMICS SHARED RESOURCE GROUP

脂质组学共享资源组

• 批准号: 8695810
• 负责人: Andrew S Kraft
• 金额: $ 8.14万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8695810
• 关键词: Antineoplastic Agents; Biochemistry; Biocompatible Materials; Biological; Cancer Center; Cancer Center Support Grant; Centers of Research Excellence; Chemicals; Clinical Trials; Databases; Development; Drug resistance; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Funding; Grant; Individual; Inflammation; Journals; Lead; Leadership; Libraries; Lipids; Malignant Neoplasms; Measurement; Medical; Metabolism; Methodology; Mission; Molecular; Molecular Biology; National Center for Research Resources; Neoplasm Metastasis; Normal Cell; Organelles; Procedures; Publications; Reagent; Research; Research Personnel; Research Support; Resource Sharing; Resources; Role; Sampling; Services; South Carolina; Sphingolipids; System; Techniques; Testing; United States National Institutes of Health; Universities; analog; anticancer research; cell transformation; cost effective; design; improved; inhibitor/antagonist; innovation; insight; instrumentation; lipid metabolism; member; operation; programs; quantum; ranpirnase; tool; translational study; tumor growth

The mission of the Lipidomics Shared Resource is to provide advanced methodology, state-of-the-art facilities, and expertise for both synthesis and analysis of bioactive lipids in a cost-effective manner for the Hollings Cancer Center (HCC). This shared resource also facilitates interactions among investigators, other shared facilities, and programs within the HCC as well as with other cancer research groups nationally and internationally. Under the leadership of Drs. Besim Ogretmen, Director, and Alicja Bielawska, Operations Director, the Lipidomics Shared Resource represents a unique scientific service for the measurement of bioactive lipid molecules with a particular focus on their role in cancers. The purposes of the Lipidomics Shared Resource are to: * Provide synthetic lipids, analogs, and inhibitors of lipid metabolism with an emphasis on sphingolipids. * Provide qualitative and quantitative analysis of lipid composition from biological materials with a current listing of more than 300 distinct molecular species. * Improve and develop new techniques for extended lipid analyses by providing a database of the lipid composition of normal and transformed cells and organelles that will permit a lipidomics approach to analysis of their cellular metabolism. * Develop cutting-edge synthetic molecular tools to study the role of bioactive lipids as new potential anticancer agents. * Develop lead compounds for translational studies. The Lipidomics Shared Resource's library of synthetic lipids, derivatives, and related molecules currently exceeds 600 compounds, several of which are emerging as Important inhibitors of enzymes of sphingolipid metabolism and being tested in clinical trials. * Educate and assist HCC investigators in designing and conducting experimental approaches aimed at the study of bioactive lipids, their metabolism, quantitation, and function. During the current CCSG project period, the Lipidomics Shared Resource has supported research that has resulted in 103 publications by 17 HCC investigators. It has supported 19 individual cancer grants at MUSC during the project period and an NIH Center of Biomedical Research Excellence (COBRE) in Lipidomics & Pathobiology (P20 RR017677, 2002-2012; P30 GM103339, 2012-2017).

脂肪组学共享资源的使命是提供先进的方法论，最先进的方法 设施和专业知识，用于以具有成本效益的Hollings Cancer Center（HCC）的成本效益方式合成和分析生物活性脂质的专业知识。这种共享资源还促进了研究人员，其他共享设施以及HCC内的其他计划以及在国内和国际上与其他癌症研究小组之间的互动。在博士的领导下。脂肪组学资源总监Alicja Bielawska总监Besim Ogretens代表了一种独特的科学服务，用于测量生物活性脂质分子，特别关注其在癌症中的作用。 脂肪组学共享资源的目的是： *提供脂质代谢的合成脂质，类似物和抑制剂，重点是鞘脂。 *对具有电流的生物材料的脂质组成进行定性和定量分析 列出了300多种不同的分子物种。 *通过提供脂质数据库来改进和开发扩展脂质分析的新技术 正常和转化的细胞和细胞器的组成将允许脂肪组学方法 分析其细胞代谢。 *开发尖端的合成分子工具来研究生物活性脂质的作用 抗癌剂。 *开发用于翻译研究的铅化合物。脂肪组学共享资源的合成脂质，衍生物和相关分子的库目前超过600种化合物，其中几种正在出现是鞘脂代谢酶的重要抑制剂，并在临床试验中进行了测试。 *教育和协助HCC调查人员设计和进行针对的实验方法 生物活性脂质的研究，它们的代谢，定量和功能。 在当前的CCSG项目期间，脂肪态学共享资源支持研究，这导致了17位HCC研究者的103份出版物。在项目期间，它支持了MUSC的19个单个癌症补助，并在脂肪组学和病理学中的NIH生物医学研究中心（COBRE）（P20 RR017677，2002-2012; P30 GM103339，2012-2017）。