Mid-Career Mentoring Award for Patient-Oriented Research in Aging

以患者为导向的老龄化研究职业中期指导奖

基本信息

批准号：
8316195
负责人：
EDWARD R MARCANTONIO
金额：
$ 19.1万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8316195
关键词：
Acute Address Affect Aging Anesthesia procedures Area Award Biological Markers Blood Blood specimen Cardiac Surgery procedures Caring Clinical Cognitive Commit Comorbidity Confusion Death Rate Delirium Development Diagnosis Diagnostic Diagnostic Procedure Elderly Environment Enzyme-Linked Immunosorbent Assay Epidemiology Functional disorder Funding Future Genetic Materials Gerontology Goals Health Health Care Costs Hip Fractures Hospitals Incidence Individual Inflammatory Inpatients Interdisciplinary Study Intervention Investigation Israel Knowledge Lead Length of Stay Mass Spectrum Analysis Measures Medical Medical center Medicine Mentors Mentorship Methods Mid-Career Clinical Scientist Award (K24)Monitor Morbidity - disease rate Operative Surgical Procedures Outcome Participant Patients Plasma Plasma Proteins Postoperative Period Primary Health Care Procedures Proteins Proteomics Quality of Care Research Research Activity Research Design Research Personnel Research Project Grants Resolution Resources Risk Risk Factors Sampling Series Severities Severity of illness Stratification Structure System Techniques Testing Time Training Translational Research United States National Institutes of Health Validation Work career career development clinical epidemiology cost cytokine functional outcomes functional status high risk improved interdisciplinary collaboration interest medical schools modifiable risk mortality patient oriented patient oriented research prevent professor programs repaired repository skills tool

项目摘要

PROJECT SUMMARY/ABSTRACT: I, Edward R. Marcantonio, MD, SM, am a board-certified geriatrician and patient-oriented aging researcher, Associate Professor of Medicine at Harvard Medical School (HMS) and Director of Research in the Division of General Medicine and Primary Care at Beth Israel Deaconess Medical Center (BIDMC). The long term objectives of my career are to conduct patient-oriented research (POR) to improve the quality of care and outcomes of hospitalized older adults, and to provide mentoring to new investigators interested in POR in aging. Over the past 16 years, I have built a successful, independent, NIH-funded program of research focused on delirium (acute confusion), a common, morbid and costly condition in hospitalized older adults. I have conducted a series of observational and interventional studies designed to improve diagnosis, target individuals at risk, identify modifiable risk factors, and test intervention strategies to reduce the incidence, severity and duration of delirium. Through these studies, I have gained the knowledge and skills necessary to conduct high quality POR and to mentor new investigators, and have been recognized for my excellence in mentoring with two prestigious awards. In this context, the primary objectives of this K24 Award are: 1. To continue to build a research program around improving the quality and outcomes of care for hospitalized older adults with delirium. This objective will be accomplished through my currently funded studies, including an NIA-funded R01 entitled 3D-CAM: Deriving and validating a 3-Minute Diagnostic Assessment for Delirium, and my new research, a Biomarker Discovery for Delirium project described in this application. Receipt of the K24 will enable me to more effectively leverage these studies and other ongoing work to support the work of trainees, who will in turn expand my research program. 2. To build a mentorship program that will expand POR in aging at BIDMC and HMS, with a focus on delirium and related conditions. This objective will be accomplished through structured, individual mentorship of young investigators with a strong interest in POR. Protected time for mentorship will be provided by the K24 award. 3. To expand my mentorship program to include translational, interdisciplinary work around biomarker discovery for delirium, and biomarker applications to improve risk stratification, diagnosis, and prognostication of older adults with delirium. This objective will be accomplished through my new research project, career development activities, and interdisciplinary collaborations that will be facilitated by receipt of the K24 award. My objectives will be greatly facilitated by the superb academic environment and outstanding institutional support provided by HMS and the BIDMC Divisions of General Medicine and Gerontology.

项目概要/摘要：我，Edward R. Marcantonio，医学博士、SM，是一名经过委员会认证的老年病学家和以患者为导向的老龄化研究员，哈佛医学院 (HMS) 医学副教授兼医学部研究主任贝斯以色列女执事医疗中心 (BIDMC) 的普通医学和初级保健。长期来看我职业生涯的目标是进行以患者为中心的研究 (POR)，以提高护理质量和住院老年人的结果，并为对 POR 感兴趣的新研究者提供指导老化。在过去的 16 年里，我建立了一个成功的、独立的、由 NIH 资助的研究项目重点关注谵妄（急性精神错乱），这是住院老年人中一种常见的病态且代价高昂的疾病。我进行了一系列观察性和介入性研究，旨在改善诊断、目标处于危险中的个体，识别可改变的危险因素，并测试干预策略以减少发生率，谵妄的严重程度和持续时间。通过这些学习，我获得了必要的知识和技能进行高质量的 POR 并指导新的研究人员，并因我在以下方面的卓越表现而受到认可指导并获得两项著名奖项。在此背景下，K24 奖的主要目标是： 1. 继续围绕提高住院护理质量和结果制定研究计划患有谵妄的老年人。这一目标将通过我目前资助的研究来实现，包括 NIA 资助的 R01，题为 3D-CAM：导出并验证谵妄的 3 分钟诊断评估，以及我的新研究，本申请中描述的 Deliium 生物标志物发现项目。收据 K24 将使我能够更有效地利用这些研究和其他正在进行的工作来支持实习生，他们将反过来扩大我的研究计划。 2. 建立一个指导计划，扩大 BIDMC 和 HMS 老龄化领域的 POR，重点关注谵妄及相关条件。这一目标将通过对年轻人的结构化、个人指导来实现对 POR 有浓厚兴趣的研究人员。 K24 奖项将提供受保护的指导时间。 3. 扩大我的指导计划，包括围绕生物标志物的转化、跨学科工作谵妄的发现和生物标志物应用以改善风险分层、诊断和预测患有谵妄的老年人。这个目标将通过我的新研究项目“职业生涯”来实现获得 K24 奖将促进开发活动和跨学科合作。一流的学术环境和优秀的机构将极大地促进我的目标的实现由 HMS 和 BIDMC 普通医学和老年学部门提供支持。