UT MD Anderson Cancer Center Network Lead Academic Participating Site (LAP)

UT MD 安德森癌症中心网络领导学术参与网站 (LAP)

• 批准号: 8605951
• 负责人: Cathy Eng
• 金额: $ 119.26万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8605951
• 关键词: Administrator; Adult; Advisory Committees; Authorship; Blood specimen; Cancer Center; Caring; Clinical; Clinical Research; Clinical Trials; Clinical Trials Cooperative Group; Clinical Trials Network; Communication; Data; Data Quality; Development; Diagnostic Imaging; Discipline; Education; Enrollment; Ensure; Faculty; Funding; General Hospitals; Goals; Grant; Group Meetings; Image; Indigent; Institution; Institutional Review Boards; Lead; Leadership; Malignant Neoplasms; Medical Oncology; Mentors; Mentorship; Minority; Mission; Operative Surgical Procedures; Participant; Pathology; Patients; Phase; Play; Principal Investigator; Protocols documentation; Publications; Radiation Oncology; Rare Diseases; Reporting; Research; Research Design; Research Personnel; Resolution; Role; Services; Site; Surgical Oncology; Texas; Therapeutic Clinical Trial; Tissues; Training; Translational Research; Underinsured; Uninsured; Work; anticancer research; cancer therapy; experience; innovation; member; multidisciplinary; novel; oncology; operation; programs; protocol development; public health relevance; skills; success

DESCRIPTION (provided by applicant): Over the past 8 years, MD Anderson has made significant contributions to cancer clinical cooperative group trials, including robust accrual, scientific and administrative leadership, and mentoring young faculty to participate in and lead these important national trials. These attributes will be applied to the emerging National Clinical Trial Network (NCTN) with even greater emphasis through this Network Lead Academic Participant (LAP) grant, with the following overall aims: Aim 1) To provide robust participation in and accrual to Network group clinical trials targeting a broad range of adult patients with common as well as rare cancers; Aim 2) To promote best practices in the conduct of NCTN-sponsored clinical research and ensure high quality and timely submission of clinical trial-related data and materials as required by specific protocols; Aim 3) To provide scientific and administrative leadership within affiliated Network Groups, including protocol development, publication authorship, participation in Network committees / NCI Central IRB (CIRB), and attendance at Network Group meetings; and Aim 4) To mentor junior faculty, research personnel, and trainees in the leadership, conduct, analysis, and reporting of NCTN and other clinical trials. This LAP utilizes a Multiple Principal Investigator (PI) Plan to apply the demonstrated and complementary cooperative group leadership skills and expertise of 3 investigators: Dr. Cathy Eng, Dr. Kelly Hunt, and Dr. Ritsuko Komaki. In addition, investigators representing the disciplines of pathology, diagnostic imaging, gynecological oncology, surgery, and translational research will play key roles In cooperative group trial conduct and mentorship of young faculty. Oversight of trial accrual and data quality, fund management, centralized communications, and administrative support will be coordinated through the LAP Operations Center under the leadership of an experienced Program Administrator. An Executive Committee will ensure timely inter-Network group communications, effective study prioritizations, review and resolution of any accrual obstacles or data quality issues, and identification of junior facult across the institution as candidates for mentorship and/or leadership roles in Network clinical trials or committees.

描述（由申请人提供）：在过去的 8 年里，MD 安德森癌症中心为癌症临床合作小组试验做出了重大贡献，包括强有力的权责发生制、科学和行政领导，以及指导年轻教师参与和领导这些重要的国家试验。这些属性将应用于新兴的国家临床 试验网络 (NCTN) 通过该网络领导学术参与者 (LAP) 资助更加重视，其总体目标如下： 目标 1) 提供强有力的参与 以及针对广泛的患有常见和罕见癌症的成年患者的网络小组临床试验的累积；目标 2) 推广进行 NCTN 资助的临床研究的最佳实践，并确保高质量和及时提交临床试验相关的资料 具体协议要求的数据和材料；目标 3) 在附属网络小组内提供科学和行政领导，包括协议开发、出版物作者身份、参与网络委员会/NCI 中央 IRB (CIRB) 以及出席网络小组会议；目标 4) 在 NCTN 和其他临床试验的领导、实施、分析和报告方面指导初级教师、研究人员和学员。该 LAP 利用多位首席研究员 (PI) 计划来应用 3 位研究员（Cathy Eng 博士、Kelly Hunt 博士和 Ritsuko Komaki 博士）所展示的和互补的合作小组领导技能和专业知识。此外，代表病理学、诊断影像、妇科肿瘤学、外科和转化研究等学科的研究人员将在合作小组试验的进行和年轻教师的指导中发挥关键作用。试验应计和数据质量、资金管理、集中通信和行政支持的监督将通过 LAP 运营中心在经验丰富的项目管理员的领导下进行协调。执行委员会将确保及时的网络小组间沟通、有效的研究优先顺序、审查和解决任何应计障碍或数据质量问题，并确定整个机构的初级教师作为网络临床试验或网络临床试验中指导和/或领导角色的候选人。委员会。