Application of Cognitive, Emotional and Biological Dimensions - Resubmission - 1

认知、情感和生物维度的应用 - 重新提交 - 1

• 批准号: 8767056
• 负责人: Isaac R Galatzer-Levy
• 金额: $ 16.73万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-08 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8767056
• 关键词: Accident and Emergency department; Acute; Algorithms; Analgesics; Apolipoprotein E; Area; Biologic Characteristic; Biological; Blood Pressure; Characteristics; Chronic; Classification; Clinical; Clinical Services; Cognition; Cognitive; Corticotropin; DRD2 gene; Data; Data Collection; Data Set; Data Sources; Demographic Factors; Development; Diagnostic; Diagnostic and Statistical Manual of Mental Disorders; Dimensions; Early Diagnosis; Early identification; Early treatment; Emotional; Emotions; Event; Exposure to; Functional disorder; Future; Genes; Genetic; Genetic Polymorphism; Goals; Growth; Heart Rate; Hospitals; Hydrocortisone; Impaired cognition; Impulsivity; Individual; Individual Differences; Intervention; Knowledge; Lead; Learning; Machine Learning; Measures; Memory; Mental Depression; Mentors; Methodology; Methods; Modeling; Natural Disasters; Neurobiology; Neurosecretory Systems; New York City; Norepinephrine; Outcome; Pain; Pathology; Patient Self-Report; Pattern; Performance; Phase; Physiological; Plasma; Post-Traumatic Stress Disorders; Prognostic Marker; Psychiatry; Psychopathology; Public Health; Recovery; Research; Research Training; Resources; Risk; Saliva; Sampling; Sleep disturbances; Social support; Solutions; Source; Stress; Survivors; Symptoms; Techniques; Testing; Therapeutic Intervention; Time; Training; Trauma; Work; base; biological adaptation to stress; burden of illness; career; demographics; depressive symptoms; design; early childhood; emotion regulation; executive function; functional disability; genetic analysis; improved; innovation; pediatric trauma; post-traumatic stress; predictive modeling; prototype; psychologic; public health relevance; resilience; response; sexual assault; skills; social; stress resilience; urinary

DESCRIPTION (provided by applicant): The goal of my proposed K01 application is to receive training and conduct research that will lead to the development of a new methodology for the early identification of posttraumatic stress outcomes. This proposal capitalizes on my previous research to identify empirically derived outcomes of posttraumatic stress and resilience that are agnostic to DSM-based diagnostic criteria. This work has identified a limited number of common patterns of response including resilience, slow recovery, and chronic posttraumatic stress. Further, the proposal capitalizes on training I have received in the neurobiology of posttraumatic stress disorder. My training throughout the K01 will focus on learning a new set of modeling techniques (Machine Learning) that will allow me to predict an individual's likely course following trauma exposure based on neuroendocrine abnormalities and cognitive and emotional characteristics in the acute phase, genetic polymorphisms, and demographic characteristics. Further, my training will focus on greatly increasing my theoretical understanding of the neurobiological underpinnings of symptom responses, as well as alterations in cognition and emotion in response to stress and traumatic stress, providing the theoretical basis for the predictive models. I have selected mentors, sponsors, and advisors who have the specific backgrounds and knowledge to aid me in achieving these goals and with whom I am currently collaborating on preliminary research in this area. The ultimate goal of this proposal is to develop new methods for the early identification of individuals in need of therapeutic intervention following trauma exposure. A second but equally important goal is the identification of new treatment targets based on abnormal characteristics that present early on in individuals who will later develop long-term posttraumatic stress outcomes. This K01 proposal is ambitious, but it is also feasible thanks to the intellectual support of my proposed mentors, sponsors, and advisors along with considerable financial and resource support from the NYU Department of Psychiatry. The combined research and training plan will provide me with skills, theoretical knowledge, and data to launch a focused independent career that fills an important public health gap. Currently, there are not suitable methods to identify individuals in need of treatment early on following trauma or methods for identifying individuals specific treatment needs. While this K01 proposal will not achieve these aims directly, it will provide me with the necessary skills to make a significant contribution in this area over the long term.

描述（由申请人提供）：我提出的K01申请的目的是接受培训和进行研究，这将导致开发一种新方法，以早期识别创伤后压力结果。该提案利用了我以前的研究，以识别创伤后压力和韧性的结果，这对基于DSM的诊断标准不可知。这项工作确定了有限的常见反应模式，包括弹性，缓慢的恢复和慢性创伤后压力。此外，该提案利用了我在创伤后应激障碍神经生物学中接受的培训。我在整个K01中的培训将着重于学习一套新的建模技术（机器学习），这将使我可以预测一个可能的课程 基于急性阶段，遗传多态性和人口特征的神经内分泌异常以及认知和情绪特征的创伤暴露。此外，我的培训将重点介绍我对症状反应神经生物学基础的理论理解，以及对压力和创伤压力的认知和情感的改变，从而为预测模型提供了理论基础。我选择了具有特定背景和知识的导师，赞助商和顾问，以帮助我实现这些目标，并且我目前正在与此方面合作在该领域进行初步研究。该提案的最终目标是开发新方法，以早期确定需要治疗干预的个人 在创伤暴露之后。第二个但同样重要的目标是基于异常特征来鉴定新的治疗靶标的，这些特征早期将出现在后来发展长期创伤后应激结局的个人中。这项K01提案是雄心勃勃的，但由于我拟议的导师，赞助商和顾问的智力支持以及纽约大学精神病学系的大量财务和资源支持，这也是可行的。合并的研究和培训计划将为我提供技能，理论知识和数据，以启动重点的独立职业，以填补重要的公共卫生差距。当前，没有合适的方法来识别需要早期治疗的人，以识别创伤或确定个人特定治疗需求的方法。尽管该K01提案无法直接实现这些目标，但从长远来看，它将为我提供在该领域做出重大贡献的必要技能。