Large-Area Plasma Panel Detectors for Particle Beam Radiation Therapy

用于粒子束放射治疗的大面积等离子体面板探测器

• 批准号: 8648242
• 负责人: Peter S Friedman
• 金额: $ 15万
• 依托单位: INTEGRATED SENSORS, LLC
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-07 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8648242
• 关键词: Area; Cells; Ceramics; Charge; Clinical; Data; Detection; Development; Devices; Diagnostic; Diagnostic radiologic examination; Dimensions; Educational workshop; Electrodes; Environment; Funding; Future; Gases; Glass; Goals; Image; Ions; Joints; Mechanics; Metals; Methods; Monitor; Monte Carlo Method; Noble Gases; Nuclear Physics; Performance; Phase; Physics; Plasma; Property; Protons; Radiation; Radiation therapy; Refractory; Reporting; Research; Resolution; Small Business Innovation Research Grant; Solutions; System; Technology; Testing; Therapeutic; Thick; Variant; attenuation; base; cost; design; detector; digital; foot; innovation; novel; particle; particle beam; programs; prototype; public health relevance; research and development; scale up; seal; sensor; simulation; treatment program

Abstract A joint DOE-NCI workshop on ion beam therapy (January 2013, Bethesda, MD) has identified an ambitious set of technological developments needed to support a world-class treatment program for ion beam therapy. One important requirement is the ability to provide detectors that afford single-particle registration at high data rates with high degree of uniformity and minimal interference with the particle beam. This would allow performing proton or ion CT prior to treatment and 2D proton, ion radiography during treatment for integrated range verification, and beam diagnostics that have minimal interference with the primary beam. The final workshop report stated "A better method of determining the stopping power, be it through proton CT or other means, would greatly increase the accuracy of the treatment, particularly when 1 mm range precision is desired. This is an important area for further R&D. We propose to develop a novel detector type, the plasma panel sensor (PPS), for proton and ion particle detection and imaging. The PPS is an inherently digital, high gain, novel variant of micropattern gas detectors inspired by many operational and fabrication principles common to plasma display panels. The PPS is comprised of a dense array of small, plasma discharge, gas cells within a hermetically sealed glass panel, and is assembled from non-reactive, intrinsically radiation-hard materials such as glass substrates, metal electrodes and mostly inert gas mixtures. Our approach is to perform the following specific aims for this Phase I SBIR proposal: Specific Aim 1: Test the feasibility and mechanical stability of a thin-glass PPS embedded in an external envelope by building a small prototype. Specific Aim 2: Define specifications for imaging with and monitoring of charged particle beams based on clinical needs. Specific Aim 3: Evaluate potential system performance with GEANT4 Monte Carlo simulations. Specific Aim 4: Develop design of a significantly higher resolution, larger area, thinner substrate Phase-II device based on the results achieved under Specific Aims 1-3

抽象的 DOE-NCI 离子束治疗联合研讨会（2013 年 1 月，马里兰州贝塞斯达）已确定 支持世界一流治疗所需的一系列雄心勃勃的技术发展 离子束治疗程序。一项重要的要求是能够提供能够 提供高数据速率下的单粒子配准，具有高度的均匀性和最小的 粒子束的干扰。这将允许在之前进行质子或离子 CT 治疗期间进行治疗和二维质子、离子射线照相以进行综合范围验证，以及 对主光束干扰最小的光束诊断。最后的研讨会 报告指出“一种更好的确定制动力的方法，无论是通过质子 CT 或 其他手段，将大大提高治疗的准确性，特别是当 1 毫米 需要范围精度。这是进一步研发的重要领域。 我们建议开发一种新型探测器，即等离子面板传感器（PPS），用于质子和 离子粒子检测和成像。 PPS 本质上是数字化、高增益、新颖的变体 微图案气体探测器的灵感来自许多常见的操作和制造原理 等离子显示面板。 PPS 由密集的小型等离子体放电气体阵列组成 电池位于密封玻璃面板内，由非反应性、本质上组装而成 抗辐射材料，例如玻璃基板、金属电极和大多数惰性气体 混合物。 我们的方法是实现第一阶段 SBIR 提案的以下具体目标： 具体目标 1：测试嵌入薄玻璃 PPS 的可行性和机械稳定性 通过构建一个小型原型来实现外部围护结构。 具体目标 2：定义带电粒子束成像和监测的规范 根据临床需要。 具体目标 3：使用 GEANT4 蒙特卡罗模拟评估潜在的系统性能。 具体目标 4：开发分辨率明显更高、面积更大、更薄的设计 基于具体目标 1-3 下取得的成果的基质 II 期设备