Neural Development of Lexical Processing

词汇处理的神经发展

基本信息

批准号：
8245106
负责人：
James R Booth
金额：
$ 55.81万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-04-01 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8245106
关键词：
11 year old 13 year old 15 year old 17 year old 7 year old Acceleration Address Adolescence Age Area Auditory Behavioral Behavioral Research Bilateral Brain Brain region Characteristics Child Childhood Cognitive Cohort Effect Comprehension Data Development Developmental Delay Disorders Diagnosis Disease Frequencies Functional Magnetic Resonance Imaging Fusiform gyrus Genetic Crossing Over Goals Grant Growth Individual Individual Differences Inferior Inferior frontal gyrus Intervention Judgment Language Language Disorders Left Linear Models Lobule Modality Modeling Oral Orthography Parietal Parietal Lobe Participant Pattern Procedures Process Reader Reading Reading Disorder Reporting Research Scanning Semantics Shapes Signal Transduction Stimulus Structure of middle temporal gyrus Study Section Techniques Testing Time Variant Visual Work base design deviant innovation interest language processing lexical lexical processing longitudinal design neurodevelopment phonology public health relevance relating to nervous system response skills spelling

项目摘要

DESCRIPTION (provided by applicant): We have formulated a developmental neuro-cognitive model of lexical processing in normal readers based on cross-sectional functional magnetic resonance imaging (fMRI) data and we have collected our first longitudinal data on these children 2 years after their initial assessment. The proposed grant will longitudinally follow normal children (7- to 17- year-olds) and children with reading disorders (11- to 15-year-olds) when they perform a variety of tasks. These tasks include orthographic (spelling), phonological (rhyming) and semantic (meaning) judgments in the visual and auditory modalities. Not only is this proposal innovative because we use a variety of tasks, but we also have multiple perceptual controls and multiple parametric manipulations of difficulty, so we can more effectively examine developmental and group effects specific to aspects of lexical processing. Furthermore, our paradigms allow an examination of priming and lexical effects (e.g. word frequency, phonological consistency and orthographic consistency) so observed developmental and group differences are not likely to be due to specific characteristics of the tasks. The overall aim of this study is to determine whether different groups have different developmental trajectories. A longitudinal design is crucial to rule out cohort effects and to examine the predictability of the individual's subsequent brain development from their earlier reading skill and brain activation patterns. In addition to examining whether higher and lower skill normal readers have different developmental trajectories, we will examine whether dyslexic readers with specific deficits in decoding orthographic stimuli have different developmental trajectories from language-impaired readers with deficits in decoding orthographic stimuli in addition to general language processing deficits. We will also compare children with disorders to age-match versus reading-match normal readers to address the question of developmental delay versus deviance. Our general hypothesis is that individual differences in brain activation between readers will increase with age. This will be tested using hierarchical linear modeling to examine growth curves in the rate of change (e.g. slope) and in the shape of change (e.g. acceleration). We will use this technique to look at developmental changes in signal intensity in our critical regions of interest, but also for changes in effective connectivity using Dynamic Causal Modeling (DCM). PUBLIC HEALTH RELEVANCE This proposal will give us basic information about how the brains of typical children change throughout childhood and adolescence during reading and language processing, but also how the brains of children with reading and language disorders differ in their development. The relevance of this grant to biomedical issues is that it has implications for diagnosis and intervention in children with reading and language disorders.

描述（由申请人提供）：我们根据横截面功能磁共振成像（fMRI）数据制定了正常阅读者词汇处理的发育神经认知模型，并且我们在这些儿童两年后收集了第一个纵向数据。初步评估。拟议的补助金将纵向跟踪正常儿童（7至17岁）和患有阅读障碍的儿童（11至15岁）执行各种任务时的情况。这些任务包括视觉和听觉模式中的正字法（拼写）、语音（押韵）和语义（意义）判断。该提议不仅具有创新性，因为我们使用了多种任务，而且我们还具有多种感知控制和多种难度参数操作，因此我们可以更有效地检查特定于词汇处理方面的发展和群体效应。此外，我们的范式允许检查启动和词汇效应（例如词频、语音一致性和拼写一致性），因此观察到的发展和群体差异不太可能是由于任务的特定特征造成的。本研究的总体目的是确定不同群体是否有不同的发展轨迹。纵向设计对于排除群体效应并根据个体早期的阅读技能和大脑激活模式检查其后续大脑发育的可预测性至关重要。除了检查较高和较低技能的正常读者是否有不同的发展轨迹外，我们还将检查在解码正字刺激方面有特定缺陷的阅读障碍读者是否与在一般语言处理之外在解码正字刺激方面存在缺陷的语言障碍读者有不同的发展轨迹赤字。我们还将患有疾病的儿童与年龄匹配的正常读者和阅读匹配的正常读者进行比较，以解决发育迟缓与异常的问题。我们的一般假设是，读者之间大脑激活的个体差异会随着年龄的增长而增加。这将使用分层线性模型进行测试，以检查变化率（例如斜率）和变化形状（例如加速度）的增长曲线。我们将使用这种技术来观察我们关键感兴趣区域中信号强度的发展变化，同时也使用动态因果模型 (DCM) 来观察有效连接的变化。公共健康相关性该提案将为我们提供有关典型儿童的大脑在整个童年和青春期在阅读和语言处理过程中如何变化的基本信息，以及患有阅读和语言障碍的儿童的大脑在发育过程中有何不同的基本信息。这笔赠款与生物医学问题的相关性在于，它对患有阅读和语言障碍的儿童的诊断和干预具有影响。

项目成果

期刊论文数量（38）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The role of inferior frontal gyrus and inferior parietal lobule in semantic processing of Chinese characters.

额下回和顶下小叶在汉字语义加工中的作用.

DOI：
发表时间：
2009-10
期刊：
影响因子：
0
作者：
Chou, Tai;Chen, Chih;Wu, Mei;Booth, James R
通讯作者：
Booth, James R

Sensitive period for white-matter connectivity of superior temporal cortex in deaf people.

聋人颞上皮层白质连接的敏感期。

DOI：
发表时间：
2012-02
期刊：
影响因子：
4.8
作者：
Li, Yanyan;Ding, Guosheng;Booth, James R;Huang, Ruiwang;Lv, Yating;Zang, Yufeng;He, Yong;Peng, Danling
通讯作者：
Peng, Danling

Developmental changes in the neural influence of sublexical information on semantic processing.

词汇下信息对语义处理的神经影响的发展变化。