2013 Infections of the Nervous System: Pathogenesis and Worldwide Impact GRC

2013 神经系统感染：发病机制和全球影响 GRC

• 批准号: 8589755
• 负责人: Diane E Griffin
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-15 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8589755
• 关键词: Address; Affect; Animal Model; Arabs; Awareness; Basic Science; Cell physiology; Cells; Characteristics; Clinical; Clinical Research; Collaborations; Communicable Diseases; Communities; Coronavirus; Country; Developing Countries; Development; Diagnostic; Disabled Persons; Disease; Dourine; Economic Development; Fatal Outcome; Fellowship; Fostering; Functional disorder; Goals; Human; Immune; Impaired cognition; Impairment; Infection; Infectious Agent; Insect Vectors; Institution; International; Invaded; Investigation; Knowledge; Laboratory Study; Life; Location; Medical; Medical Research; Mission; Molecular; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Nature; Nervous System Trauma; Nervous system structure; Neurologic; Neurons; Oral; Outcome; Pathogenesis; Patients; Planets; Prevention; Primates; Research; Research Personnel; Research Training; Resources; Rodent; Science; Scientist; Series; Societies; Time; Training Programs; Visit; Work; base; burden of illness; climate change; drug discovery; global health; handicapping condition; improved; lectures; man; meetings; multidisciplinary; neglect; nervous system disorder; nervous system infection; neurotropic; new technology; pathogen; patient oriented research; posters; public health relevance; receptor; relating to nervous system; reproductive; response; socioeconomics; symposium; tool

DESCRIPTION (provided by applicant): We propose to hold a new Gordon Research Conference (GRC) on "Infections of the nervous system: pathogenesis and world impact" because neurotropic pathogens contribute significantly to human suffering and disease burden throughout the world, particularly in tropical and developing countries. In comparison to studies on infections of the nervous system in western societies, studies on diseases of such nature in the developing world have been neglected. This is paradoxical as neurotropic pathogens are frequent in the developing world and contribute significantly to human suffering and disease burden. Moreover living with neurological handicap and/or cognitive dysfunction will have a significant impact on socio-economic development. The conference will have an unprecedented broad scope, gathering leading scientists on major diseases caused by these pathogens. Our goals are to advance knowledge in the field and promote exchanges between medical research centers in resource-rich and -poor regions. This new series of GRC will bring together renowned clinicians and scientists, who investigate clinical disease manifestations and the molecular mechanisms underlying worldwide infections of the nervous system in humans. The establishment of a strong community of top-ranked scientists working on infections of the nervous system will also increase the awareness of world-leading research institutions on the impact and challenges in this field and foster new research and training programs in that topic. The conference will open with keynote lectures followed by scientific sessions that will address in detail how ways of invading the nervous system vary between pathogens; what are the specific neural target cells and their receptors for neurotropic pathogens; what are the characteristics of the immune and neural responses to invading pathogens; how clinical and pathogenesis studies can elucidate the nature of the nervous system damage caused by different pathogens; what are the new prospects for therapies and diagnostic in some of the diseases covered. The format of GRC (community- based, small audience, focus on unpublished material) is ideal to create a multidisciplinary dialogue that will involve both clinicians and scientists. In this context, another important objective of the conference will be t attract from all continents an audience of young researchers/trainees in the field, particularly those where these diseases are prevalent, who will present posters and/or short oral presentations, giving them ample time to discuss their work with the experts. It is, therefore, crucial that this conference can count on and support the presence of the best scientists in the field. We believe that this conference will advance the mission of NINDS by expanding the knowledge on clinical aspects and pathogenesis of these devastating neurological diseases and promoting progress in their prevention, diagnostic and therapies. Bruzzone GRC 2013 Infections of the nervous system .

描述（由申请人提供）：我们提议举办一次新的戈登研究会议（GRC），主题为“神经系统感染：发病机制和世界影响”，因为嗜神经病原体对全世界人类的痛苦和疾病负担有重大影响，特别是在热带地区和发展中国家。与西方社会对神经系统感染的研究相比，对发展中国家此类疾病的研究一直被忽视。这是自相矛盾的，因为嗜神经病原体在发展中国家很常见，并且对人类的痛苦和疾病负担造成了重大影响。此外，患有神经障碍和/或认知功能障碍将对社会经济发展产生重大影响。此次会议的范围将空前广泛，聚集了研究这些病原体引起的重大疾病的顶尖科学家。我们的目标是推进该领域的知识并促进资源丰富和贫困地区医学研究中心之间的交流。这个新系列的 GRC 将汇集著名的临床医生和科学家，他们研究临床疾病表现和全球人类神经系统感染的分子机制。建立一个由研究神经系统感染的顶级科学家组成的强大社区，还将提高世界领先研究机构对该领域影响和挑战的认识，并促进该主题的新研究和培训项目。会议将以主题演讲开始，随后是科学会议，详细讨论不同病原体入侵神经系统的方式有何不同；嗜神经病原体的特定神经靶细胞及其受体是什么？对入侵病原体的免疫和神经反应有何特点？临床和发病机制研究如何阐明不同病原体引起的神经系统损伤的性质；所涵盖的一些疾病的治疗和诊断的新前景是什么？ GRC（基于社区、小受众、关注未发表材料）的形式非常适合创建临床医生和科学家参与的多学科对话。在这种背景下，会议的另一个重要目标将是吸引来自各大洲的该领域的年轻研究人员/受训人员，特别是那些疾病流行的地区，他们将展示海报和/或简短的口头报告，为他们提供充足的信息。是时候与专家讨论他们的工作了。因此，至关重要的是，这次会议可以依靠并支持该领域最优秀的科学家的出席。我们相信，本次会议将通过扩大对这些破坏性神经系统疾病的临床方面和发病机制的了解，并促进其预防、诊断和治疗方面的进展，从而推进 NINDS 的使命。 Bruzzone GRC 2013 神经系统感染。