Mali International Center for Excellence in Research

马里国际卓越研究中心

• 批准号: 8946551
• 负责人: Heinrich Feldmann
• 金额: $ 40.76万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8946551
• 关键词: Area; Arenavirus; British; Coronavirus; Cytomegalovirus; Disease; Fever; Filovirus; Flavivirus; Genetic; Geographic Distribution; Hantavirus; Human; Incidence; Infection; Lassa Fever; Lassa virus; Mali; Maps; Mastomys; Orthobunyavirus; Paramyxovirus; Publishing; Research; Rodent; Viral; Virus; Virus Diseases; field study; infected vector rodent; international center; pathogen; programs; response; Area; Arenavirus; British; Coronavirus; Cytomegalovirus; Disease; Fever; Filovirus; Flavivirus; Genetic; Geographic Distribution; Hantavirus; Human; Incidence; Infection; Lassa Fever; Lassa virus; Mali; Maps; Mastomys; Orthobunyavirus; Paramyxovirus; Publishing; Research; Rodent; Viral; Virus; Virus Diseases; field study; infected vector rodent; international center; pathogen; programs; response

In 2010, we published the first description of a genetically unique strain of Lassa virus isolated from Mastomys natalensis captured in Mali, an area previously thought to be Lassa virus free (Safronetz et al. 2010). Over the last four years we have continued to conduct field studies mapping the geographic distribution of Lassa virus in peridomestic settings across sub-Saharan Mali. With a better understanding of the regions endemic for this virus in Mali, the Lassa program is transitioning into studies aimed at defining the infection dynamics and transmissibility of Lassa in the natural rodent hosts, as well as defining the incidence rates of Lassa virus infection in humans. The Mali field program has now expanded to include other zoonotic viruses including surveillance for additional arenaviruses, hantaviruses, MERS-CoV, and CCHFV, as well as rodent-specific pathogens including cytomegalovirus.

在2010年，我们发表了对从马里捕获的乳mant鼠纳塔尔氏菌分离的遗传学菌株的第一个描述，该菌株以前被认为是不含Lassa病毒的地区（Safronetz等人，2010年）。在过去的四年中，我们继续进行现场研究，映射撒哈拉以南马里底部的植物性环境中LASSA病毒的地理分布。通过更好地了解马里这种病毒的地区，LASSA计划正在转变为旨在定义自然啮齿动物宿主中LASSA的感染动力学和可传播性的研究，并确定了人类中LASSA病毒感染的发病率。马里现场计划现已扩展到包括其他人畜共患病毒，包括其他体育症病毒，汉坦病毒，MERS-COV和CCHFV的监视，以及包括颗粒病毒在内的啮齿动物特异性病原体。