Uganda International Center for Excellence in Research

乌干达国际卓越研究中心

基本信息

批准号：
10272203
负责人：
Heinrich Feldmann
金额：
$ 6.64万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10272203
关键词：
2019-nCoV Africa Animal Model Animals Arenavirus Arthropod Vectors Bacteria Biological Assay Bunyaviridae Cell Culture System Coronavirus Data Democratic Republic of the Congo Detection Development Disease Disease Outbreaks Ebola Ecology Epidemiology Equipment Etiology Fever Filovirus Flavivirus Funding Health Human In Vitro International Intervention Laboratories Lassa Fever Link Livestock Microbiology Modernization Molecular National Institute of Allergy and Infectious Disease Nigeria Population Population Surveillance Research Research Institute Risk Assessment Rodent Role Schedule Serologic tests Serological Site Surveillance Program Therapeutic Time Training and Education Uganda Vaccines Viral Virus Work Zoonoses base clinically relevant field study global health in vivo insight international center pandemic disease pathogen pathogenic bacteria postgraduate education programs training opportunity transmission process

项目摘要

Emerging/re-emerging zoonotic diseases are a major global health problem. Linking comprehensive pathogen surveillance of arthropod/vector populations in Uganda with public health surveillance at the regional and international level will make an important contribution to human and animal health in East Africa and the One World One Health concept in general. There will be a focus on rodent-borne pathogens potentially causing disease in humans, wildlife and livestock. A more comprehensive understanding of the ecology of known and unknown rodent-borne zoonotic pathogens is essential for a risk assessment for local and global human and animal health. The establishment of emerging/re-emerging virus program on the campus of the Uganda Virus Research Institute (UVRI), Entebbe, Uganda is ongoing. Rakai is no longer considered as a second program site. We have procured most of the necessary equipment for the UVRI site; further equipment will be purchased when needed. Over the previous and current funding period we have refined molecular and serological detection assays for several pathogens including arenaviruses, bunyaviruses, coronaviruses filoviruses, and flaviviruses. The ongoing SARS-CoV-2 pandemic and several ongoing outbreaks, such as the Ebola in the Democratic Republic of the Congo (DRC) and the ongoing Lassa fever outbreak in Nigeria, have delayed this project multiple times. Nevertheless, we continue to advance our molecular and serological assays that will be deployed to Uganda as soon as the lab space at UVRI is available and functional. Field work is now scheduled to start in the upcoming fiscal year.

新兴/重新出现的人畜共患病是全球主要的健康问题。将乌干达节肢动物/载体种群的全面病原体监测与区域和国际水平的公共卫生监测联系起来将为东非的人类和动物健康做出重要贡献，而总体上，一个世界一个健康概念。将关注啮齿传播的病原体，可能引起人类，野生动植物和牲畜的疾病。对已知和未知啮齿动物的人畜共患病原体的生态学更全面的了解对于对本地和全球人类和动物健康的风险评估至关重要。在乌干达的乌干达病毒研究所（UVRI）校园内建立新兴/重新出现的病毒计划正在进行中。 Rakai不再被视为第二个程序网站。我们为UVRI站点采购了大多数必要的设备；需要在需要时购买更多设备。在过去和当前的融资期间，我们对包括体育症病毒，Bunyaviruses，冠状病毒和黄病毒在内的几种病原体进行了分子和血清学检测测定。正在进行的SARS-COV-2大流行和正在进行的爆发爆发，例如刚果民主共和国（DRC）的埃博拉病毒和尼日利亚正在进行的LASSA热爆发，已多次推迟该项目。然而，我们将继续推进分子和血清学测定法，一旦UVRI的实验室空间可用并且功能正常，这些分子和血清学分析将立即部署到乌干达。现场工作现在定于即将到来的财政年度开始。