Genomic Medicine Pilot Demonstration Projects Coordinating Center

基因组医学试点示范项目协调中心

• 批准号: 8682895
• 负责人: Stephen E. Kimmel
• 金额: $ 39.2万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-16 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8682895
• 关键词: Address; Award; Bioinformatics; Clinical; Clinical Trials; Collaborations; Communication; Communities; Community Medicine; Complex; Computerized Medical Record; Data; Development; Effectiveness; Electronic Health Record; Ensure; Ethics; Genetic; Genetic Counseling; Genomics; Goals; Grant; Health; Health Communication; Health Status; Healthcare; Healthcare Systems; Human; Human Resources; Individual; Informatics; Institution; Knowledge; Leadership; Logistics; Maintenance; Mediation; Medicine; Methods; National Human Genome Research Institute; Observational Study; Outcome Measure; Patients; Pennsylvania; Process; Process Measure; Public Health; Research; Research Infrastructure; Research Personnel; Site; Solutions; Sum; United States National Institutes of Health; Universities; Work; biomedical informatics; clinical practice; design; ethical legal social implication; experience; flexibility; implementation science; improved; insight; legal implication; meetings; member; multidisciplinary; programs; public health relevance; social implication; statistics; success; tool

DESCRIPTION (provided by applicant): The challenges to integrating genomic findings into healthcare practice are complex and exist at multiple levels of the health care system. A collaborative, strategic, and rigorous approach to addressing the barriers and applying solutions to genomic implementation is therefore required to maximize its public health impact. The goal of the Coordinating Center at the University of Pennsylvania is to ensure the success of individual Genomic Pilot Demonstration Projects while stimulating collaboration across projects to produce and disseminate generalizable knowledge. Such knowledge can be used to sustain and expand existing efforts and to inform implementation in other clinical settings. The applicant team has extensive experience in all aspects required of the coordinating center to achieve these goals. The investigators bring insights and expertise from ongoing coordinating center leadership and collaborative genomic implementation projects; from University of Pennsylvania Centers devoted to implementation of genomics in practice, ELSI (Ethical Legal and Social Implications), statistical genetics, bioinformatics, and health communications; and from experience evaluating the efficacy and effectiveness of implementation strategies. The team proposes to use a conceptual and operational framework for collaboration borrowed from implementation science, one designed to not only assess effectiveness of implementations but also to inform their development and improve their chances of success, sustainability, and dissemination. The use of a mutually agreed-upon framework will help guide each step of the implementation process, e.g., integrating genomic findings into electronic health records, developing clinical decision support tools, and defining and measuring outcomes of implementation. The ultimate goal will be to advance the field of genomic implementation science and leverage the expertise within this and other NHGRI consortia so that the contributions of the consortia are greater than the sum of their parts.

描述（由申请人提供）：将基因组发现整合到医疗保健实践中的挑战很复杂，并且存在于医疗保健系统的多个层面。因此，需要采取协作、战略和严格的方法来解决障碍并将解决方案应用于基因组实施，以最大限度地发挥其公共卫生影响。宾夕法尼亚大学协调中心的目标是确保各个基因组试点示范项目的成功，同时促进项目之间的合作以产生和传播通用知识。这些知识可用于维持和扩大现有的努力，并为其他临床环境中的实施提供信息。申请团队在协调中心实现这些目标所需的各个方面都拥有丰富的经验。研究人员从正在进行的协调中心领导和协作基因组实施项目中带来见解和专业知识；来自宾夕法尼亚大学中心，致力于在实践中实施基因组学、ELSI（道德法律和社会影响）、统计遗传学、生物信息学和健康传播；并根据经验评估实施战略的效力和有效性。该团队建议使用借鉴实施科学的概念和操作框架进行协作，该框架不仅旨在评估实施的有效性，而且还为实施的发展提供信息，并提高其成功、可持续性和传播的机会。使用双方同意的框架将有助于指导实施过程的每一步，例如，将基因组发现整合到电子健康记录中，开发临床决策支持工具，以及定义和衡量实施结果。最终目标是推进基因组实施科学领域的发展，并利用该联盟和其他 NHGRI 联盟的专业知识，使联盟的贡献大于各个联盟的贡献之和。