Natural Product Treatments for Leishmaniasis

治疗利什曼病的天然产品

基本信息

批准号：
8721327
负责人：
BILL J BAKER
金额：
$ 22.43万
依托单位：
UNIVERSITY OF SOUTH FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-15 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8721327
关键词：
Affect Algae Amphotericin B Antarctic Attention Biodiversity Biological Assay Biological Factors Cachexia Cessation of life Chemicals Chemistry Collection Complement Country Cutaneous Cutaneous Leishmaniasis Data Developed Countries Development Disease Disease model Drug resistance Ecosystem Evaluation Fermentation Fever Generations HIV Hepatosplenomegaly Human Incidence Infection Inhibitory Concentration 50 Invertebrates Leishmania Leishmania donovani Leishmaniasis Lesion Life Malignant Neoplasms Marines Military Personnel Miltefosine Modeling Morbidity - disease rate Paclitaxel Parasites Pharmaceutical Preparations Pharmacologic Substance Plants Production Prunella vulgaris Reproduction spores Research Research Priority Resources Risk Role Sampling Sea Sea Ice Soil Source Southern Ocean Tropical Disease United States Food and Drug Administration Visceral Visceral Leishmaniasis World Health Organization base climate change cytopenia cytotoxicity drug development drug discovery endophytic fungi follow-up fungus indexing interest macrophage microbial microbial community microorganism mortality neglect novel operation public health relevance public-private partnership screening small molecule

项目摘要

DESCRIPTION (provided by applicant): Leishmaniasis exacts a staggering toll of mortality and morbidity on the developing world. Infection with parasites of the genus Leishmania causes a spectrum of disease in humans ranging from self-healing cutaneous lesions to life-threatening visceral infections. Two million new cases of leishmaniasis occur annually (1.5 million for cutaneous leishmaniasis and 500,000 for visceral leishmaniasis and over 350 million people are at risk of acquiring leishmaniasis, which is one of six diseases on the World Health Organization Tropical Disease Research (WHO TDR) list for priority research. The incidence of leishmaniasis may be increasing, and there is also growing interest in leishmaniasis in industrialized countries, in part due to the increase of Leishmania-HIV co-infection and the importance of the disease in current military operations. Leishmaniasis is most often treated by parenteral administration of toxic drugs such as pentavalent antimonials and amphotericin B, and drug resistance is becoming a problem. For the treatment of cutaneous leishmaniasis, a variety of drugs are frequently used, but none is effective against all species of the parasite that cause cutaneous disease. Herein we propose to investigate several niche sources of unstudied or understudied biodiversity in the search for new natural product chemotypes for treating leishmaniasis. Natural products represent 9 of 13 anti-parasitic drugs approved by the U.S. Food and Drug Administration in the past 25 years, highlighting the important role of this drug discovery resource for antileishmanial drug discovery research.

描述（由申请人提供）：利什曼病在发展中国家对死亡率和发病率的惊人损失。利什曼原虫属的寄生虫感染引起人类的各种疾病，从自我修复的皮肤病变为威胁生命的内脏感染。每年发生200万例新的利什曼病病例（皮肤利什曼病150万例，内脏利什曼病和50万例，超过3.5亿人有收购利什曼病的风险，这是世界卫生组织热带疾病研究（WHO TDR）清单上六种疾病之一对于优先研究部分原因是利什曼尼亚-HIV共同感染以及该疾病在当前军事行动中的重要性。利什曼病通常是通过肠胃外给药的有毒药物（如五价抗微药物和两性霉素B）来治疗的，耐药性正成为一个问题。为了治疗皮肤利什曼病，经常使用多种药物，但没有任何药物对引起皮肤疾病的所有寄生虫物种有效。本文中，我们建议研究几个未研究或研究的生物多样性的利基来源，以寻找用于治疗利什曼病的新天然产物化学型。天然产品代表了过去25年中美国食品药品监督管理局批准的13种抗寄生液中的9种，强调了这种药物发现资源在抗精神经会药物发现研究中的重要作用。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Shagenes A and B, new tricyclic sesquiterpenes produced by an undescribed Antarctic octocoral.

DOI：
10.1021/ol500792x
发表时间：
2014-05-16
期刊：
ORGANIC LETTERS
影响因子：
5.2
作者：
von Salm, Jacqueline L.;Wilson, Nerida G.;Vesely, Brian A.;Kyle, Dennis E.;Cuce, Jason;Baker, Bill J.
通讯作者：
Baker, Bill J.

Spongian Diterpenoids Derived from the Antarctic Sponge Dendrilla antarctica Are Potent Inhibitors of the Leishmania Parasite.

DOI：
10.1021/acs.jnatprod.0c00025
发表时间：
2020-05-22
期刊：
Journal of natural products
影响因子：
5.1
作者：
Shilling AJ;Witowski CG;Maschek JA;Azhari A;Vesely BA;Kyle DE;Amsler CD;McClintock JB;Baker BJ
通讯作者：
Baker BJ

Chemistry and Bioactivity of the Deep-Water Antarctic Octocoral Alcyonium sp.